The effects of resistance training on myostatin and follistatin in adults: A systematic review and meta-analysis

Khalafi, Mousa; Aria, Behzad; Symonds, Michael; Rosenkranz, Sara K.

doi:10.1016/j.physbeh.2023.114272

Cited by 10 publications

(3 citation statements)

References 72 publications

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“…Aerobic exercise significantly reduces the inflammatory load in type 2 diabetes by improving circulating levels of factors such as resistin, TNF-α, and IL-6 ( Papagianni et al, 2023 ). On the other hand, resistance training, characterized by high-intensity muscle contractions, suppresses the release of MSTN ( Khalafi et al, 2023 ). Moreover, exercise-induced factors respond to endurance differently from high-intensity interval training (HIIT).…”

Section: Survey Methodologymentioning

confidence: 99%

Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation

Zhou,

Gong,

Zhang

et al. 2024

PeerJ

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Exercise has many beneficial effects that provide health and metabolic benefits. Signaling molecules are released from organs and tissues in response to exercise stimuli and are widely termed exerkines, which exert influence on a multitude of intricate multi-tissue processes, such as muscle, adipose tissue, pancreas, liver, cardiovascular tissue, kidney, and bone. For the metabolic effect, exerkines regulate the metabolic homeostasis of organisms by increasing glucose uptake and improving fat synthesis. For the anti-inflammatory effect, exerkines positively influence various chronic inflammation-related diseases, such as type 2 diabetes and atherosclerosis. This review highlights the prospective contribution of exerkines in regulating metabolism, augmenting the anti-inflammatory effects, and providing additional advantages associated with exercise. Moreover, a comprehensive overview and analysis of recent advancements are provided in this review, in addition to predicting future applications used as a potential biomarker or therapeutic target to benefit patients with chronic diseases.

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Section: Survey Methodologymentioning

confidence: 99%

Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation

Zhou,

Gong,

Zhang

et al. 2024

PeerJ

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“…Similarly, Luo et al discovered that deletion of the MSTN gene modifies the gut microbiome, promoting the formation of fast-twitch glycolytic muscle in mice [ 140 ]. Interestingly, resistance training for a minimum of five weeks was found to be beneficial in lowering myostatin levels in healthy people [ 142 ].…”

Section: A Healthy Gut Microbiomementioning

confidence: 99%

Revitalizing the Gut Microbiome in Chronic Kidney Disease: A Comprehensive Exploration of the Therapeutic Potential of Physical Activity

Vandecruys,

De Smet,

De Beir

et al. 2024

Toxins

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Both physical inactivity and disruptions in the gut microbiome appear to be prevalent in patients with chronic kidney disease (CKD). Engaging in physical activity could present a novel nonpharmacological strategy for enhancing the gut microbiome and mitigating the adverse effects associated with microbial dysbiosis in individuals with CKD. This narrative review explores the underlying mechanisms through which physical activity may favorably modulate microbial health, either through direct impact on the gut or through interorgan crosstalk. Also, the development of microbial dysbiosis and its interplay with physical inactivity in patients with CKD are discussed. Mechanisms and interventions through which physical activity may restore gut homeostasis in individuals with CKD are explored.

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“…During muscle contraction, the production and secretion of specific myokines are stimulated, and myokines can act with endocrine, autocrine and/or paracrine action. In addition to MYO and to its primary antagonist FOL [ 5 ], other myokines of interest are the following: the adipomyokine Follistatin-like 1 [ 6 ] (FSTL-1), Musclin (MUS) [ 7 ], Oncostatin (ONC) [ 8 ], Osteonectin (OST) [ 9 ], Irisin (IRI) [ 10 ], Brain Derived Neurotrophic Factor (BDNF) [ 11 ], Insulin-like Growth Factor 1 (IGF1) [ 12 ], some interleukins such as IL-6, IL-13, IL-15 [ 13 ] and some other growth factors such as Fibroblast Growth Factor-21 (FGF-21) [ 14 ] and also Erythropoietin (EPO) [ 15 ]. The activity of all these myokines is related to the trophic state and to the activity of the skeletal muscle; moreover, their action is often synergistic.…”

Section: Introductionmentioning

confidence: 99%

Serum myokines as potential biomarkers of myostatin inhibition in sport doping: a preliminary study on their baseline levels in elite athletes

Donati,

Biasini,

de la Torre

et al. 2024

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We considered in this study the possibility of developing an indirect procedure for detecting myostatin inhibition/suppression, a practice that is prohibited as doping in sport. We have specifically considered the potential diagnostic utility of human serum myokines as indirect markers of myostatin inhibition. Myostatin, its main antagonist follistatin, and other myokines (follistatin-like 1, musclin, oncostatin, osteonectin, irisin, brain derived neurotrophic factor, and insulin-like growth factor-1) were selected as a panel of potential biomarkers whose levels may be altered following myostatine suppression. The serum levels of myostatin and of the nine myokines were measured in elite athletes of different age, sex, and sport discipline, and their cross correlation assessed by multivariate analysis. All myokines resulted to be measurable in human serum, except for musclin and irisine, whose levels were below the limits of quantitation in a reduced number of samples. Serum concentrations varied of different orders in magnitude (musclin and osteonectin < 1 ng/mL; follistatin, myostatine and irisine 1–5 ng/mL; brainderived neurotrophic factor, follistatin-like 1 and iinsulin-like growth factor-1 > 10 ng/mL), while no significant differences were found between female and male subjects, with the exceptions of follistatin-like 1 and musclin, showing a higher concentrations in females (p < 0.05). Levels of insulin-like growth factor 1 and brain derived neurotrophic factor were significantly higher in power athletes than in endurance ones. Multivariate statistics showed that musclin, follistatin-like 1 and oncostatin are more clustered and correlated to myostatin than other myokines, suggesting they could be considered as potential biomarkers of doping by myostatin inhibitors.

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The effects of resistance training on myostatin and follistatin in adults: A systematic review and meta-analysis

Cited by 10 publications

References 72 publications

Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation

Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation

Revitalizing the Gut Microbiome in Chronic Kidney Disease: A Comprehensive Exploration of the Therapeutic Potential of Physical Activity

Serum myokines as potential biomarkers of myostatin inhibition in sport doping: a preliminary study on their baseline levels in elite athletes

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