The Effects of Respiratory Muscle Weakness and Pulmonary Involvement on Functional Status, Fatigue and Health Related Quality of Life in Patients With Systemic Sclerosis

Kesikburun, Bilge; Köseoğlu, Belma Füsun; Şahin, Ali; Turgay, Murat; Doğan, Asuman; Öken, Öznur

doi:10.5606/archrheumatol.2015.5238

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…In our study, in accordance with the literature, the expected % value of MIP and MEP in SSc patients in both groups was found to be lower than the stated normal values (80%) 38,39 . A previous study stated that respiratory muscle weakness in SSc patients was associated with increased severity of dyspnea, decreased exercise capacity, and impaired QoL 35 . Therefore, there is a need for treatment strategies to improve respiratory muscle strength in this group.…”

Section: Discussionsupporting

confidence: 91%

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Effects of supervised exercise program and home exercise program in patients with systemic sclerosis: A randomized controlled trial

et al. 2021

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Aim To compare the effects of supervised exercise and home exercise program in patients with systemic sclerosis (SSc). Methods Thirty‐seven SSc patients were included. Patients with SSc were allocated into 2 groups as supervised and home exercise. Breathing, aerobic and resistance exercises were performed with a physiotherapist for 12 weeks in the supervised exercise group. Breathing, posture and aerobic exercises were given to the home exercise group as a home program for 12 weeks. All patients were assessed at baseline and 12 weeks later in terms of functional capacity, pulmonary functions, respiratory‐peripheral muscle strength, dyspnea severity, health‐related quality of life (HRQoL) and fatigue level. Results Significant improvements were observed in the functional capacity, measured by 6 minute walking test in the supervised exercise group (before = 376.21 ± 65.50, after = 518.78 ± 75.84 m) and home exercise group (before = 384.44 ± 68.14, after = 432.7 ± 70.8 m; (P < .05). Respiratory‐peripheral muscle strength (with the exception of inspiratory muscle strength and upper limb strength in the home exercise group) and HRQoL were significantly increased and fatigue level was significantly decreased in the supervised exercise and home exercise groups (P < .05). However, pulmonary functions and dyspnea severity were significantly improved only in the supervised exercise group (P < .05). The supervised exercise program was found superior to the home exercise program for change in all parameters (P < .05). Conclusion This study suggests that exercise interventions should be applied in addition to the medical treatments of patients with SSc as supervised and home exercise programs play an important role in the functionality and health status of these patients.

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Section: Discussionsupporting

confidence: 91%

“…Similar to other studies, in our study, the baseline FEV 1 %, FVC%, DLCO, PEF values of SSc patients in both groups were lower than the normal values (80% and above) and the FEV 1 /FVC% ratio was found to be within normal limits 35,36 . FEV 1 %, FVC%, PEF% and DLCO% values increased significantly after 12 weeks exercise program in the SEG.…”

Section: Discussionsupporting

confidence: 90%

Effects of supervised exercise program and home exercise program in patients with systemic sclerosis: A randomized controlled trial

et al. 2021

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“…Among these studies, five articles provided scores for all the eight domains of the SF‐36 questionnaire and two articles reported the two summary scores (PCS and MCS) . Of the seven published studies, one was conducted in Netherlands, one in Canada, one in Italy, one in China, one in Turkey, one in Brazil and one in Britain . When evaluated by Modified Newcastle‐Ottawa quality assessment criteria, quality of articles were divided into the following four levels: poor quality, moderate quality, high quality and very high quality.…”

Section: Resultsmentioning

confidence: 99%

The impact of systemic sclerosis on health‐related quality of life assessed by SF‐36: A systematic review and meta‐analysis

et al. 2018

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Objective The purpose of this meta‐analysis was to systematically review the literature to evaluate the impact of systemic sclerosis (SSc) on the health‐related quality of life (HRQoL) assessed by the Medical Outcomes Short‐Form‐36 questionnaire (SF‐36). Methods A systematic literature search was performed on PubMed, Web of Science and Embase until April 2017 to obtain eligible studies. Random effect model was performed to summarize the scores of each domain. Scores from the SF‐36 questionnaire were used as the outcome measurements, and mean differences with 95% confidence intervals were calculated. Results In total, seven studies were eligible for inclusion criteria, comprising 795 SSc patients and 1154 healthy controls. The SF‐36 questionnaire score of each domain (physical function, role physical function, emotional role function, vitality, mental health, social function, body pain, general health) was lower in SSc patients than in healthy controls, meanwhile, physical component scale (PCS) and mental component scale (MCS) scores were all lower in patients with SSc than in healthy controls. Likewise, pooled mean scores of PCS and MCS ranged from 31.20 to 52.80, 37.40 to 68.30, respectively. Additionally, the score of PCS was lower than that of MCS in SSc patients. Conclusions This meta‐analysis showed that SSc patients had lower HRQoL than healthy controls, and SSc had negative influence on the HRQoL of patients. This indicates that clinical workers should pay more attention to SSc patients' HRQoL, so as to improve global health of patients with SSc.

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“…2,3 Fatigue is increasingly recognized in patients with SSc as a debilitating and bothersome symptom which rated similarly to those patients with other forms of rheumatic disorders and worse than in the general population and cancer patients in remission. 4,5 However, assessment of fatigue in SSc has been generally conducted using single-item rating which causes a limitation. Multidimensional assessment of fatigue (MAF) scale, as well as Fatigue Severity Scale (FSS), may allow more detailed evaluation of fatigue in SSc.…”

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confidence: 99%

The Turkish Version of Multidimensional Assessment of Fatigue and Fatigue Severity Scale is Reproducible and Correlated With Other Outcome Measures in Patients With Systemic Sclerosis

et al. 2016

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Objectives: This study aims to evaluate the reproducibility of Turkish versions of multidimensional assessment of fatigue (MAF) and fatigue severity scales (FSS) and the relationship between health related quality of life, disability, and psychological status in patients with systemic sclerosis (SSc). Patients and methods: A total of 21 female patients (mean age 47.14±10.39 years; range 18 to 75 years) who met 2013 American College of Rheumatology/European League Against Rheumatism criteria for SSc were evaluated for severity of organ involvement and symptoms. Turkish version of MAF, FSS, and visual analog scale of fatigue were assessed at baseline and after two to three weeks. Level of dyspnea was noted and disability, functional limitation, and quality of life were assessed by health assessment questionnaire, 6-minute walking distance, and short-form 36, respectively. Results: Ten patients had diffuse and 11 had limited SSc. MAF subscales and FSS had significant correlations with short-form 36-vitality subscale and 6-minute walking distance. Intraclass correlation coefficients for FSS and visual analog scale of fatigue were 0.824 (95% confidence interval, 0.566-0.929) and 0.932 (95% confidence interval, 0.832-0.972), respectively. The intraclass correlation coefficients for MAF subscales changed between 0.916 and 0.968, except for MAF-timing (intraclass correlation coefficient, 0.404). Conclusion: Our results revealed that FSS and MAF subscales had high reproducibility and correlated well with quality of life and disability scales which, to some extent, may suggest convergent validity of MAF subscales and FSS in SSc. The incompatible nature and four-choice answering in two items of MAF-timing may be the underlying reason for trivial relationship with other parameters. The Turkish version of MAF and FSS may be used to assess fatigue in patients with SSc.

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The Effects of Respiratory Muscle Weakness and Pulmonary Involvement on Functional Status, Fatigue and Health Related Quality of Life in Patients With Systemic Sclerosis

Cited by 5 publications

References 25 publications

Effects of supervised exercise program and home exercise program in patients with systemic sclerosis: A randomized controlled trial

Effects of supervised exercise program and home exercise program in patients with systemic sclerosis: A randomized controlled trial

The impact of systemic sclerosis on health‐related quality of life assessed by SF‐36: A systematic review and meta‐analysis

The Turkish Version of Multidimensional Assessment of Fatigue and Fatigue Severity Scale is Reproducible and Correlated With Other Outcome Measures in Patients With Systemic Sclerosis

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