The effects of resveratrol intervention on risk markers of cardiovascular health in overweight and obese subjects: a pooled analysis of randomized controlled trials

Huang, Haohai; Chen, Guangzhao; Liao, Dan; Zhu, Yunqing; Pu, Rong; Xue, Xiaonan

doi:10.1111/obr.12458

Cited by 57 publications

(41 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, significant reduction in total cholesterol, systolic blood pressure, diastolic blood pressure, glucose, and insulin have been shown in obese subjects taking 300 mg or more of resveratrol per day [14]. There is also some evidence to suggest resveratrol may have therapeutic potential for management of congestive heart failure [15].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Resveratrol for Cardiovascular Protection

Yeung¹

2017

Cardiovasc Pharm Open Access

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Resveratrol for Cardiovascular Protection

Yeung¹

2017

Cardiovasc Pharm Open Access

View full text Add to dashboard Cite

“…Whereas, not all the trials that evaluated the blood inflammatory markers obtained an improvement in these parameters. For example, there were no significant alterations in the plasma values of CRP in four of the six studies analyzed 17,8,20,26 .…”

Section: Effects Of Interventionsmentioning

confidence: 99%

“…Accumulation of this lipoprotein occurs as a result of environmental factors, mainly connected with diet and genetic aspects 7 . In this context, resveratrol, a polyphenolic compound found in grape skins, red wine, eucalyptus and peanuts is found, whose benefits have become recognized worldwide, due to its antioxidant and anti-inflammatory properties, in addition to the capacity to inhibit LDL oxidation, and stimulate nitric oxide (NO) production, which characterize it as a cardiovascular protector 8 . From this perspective, the "French paradox" -an expression attributed to the low incidence of coronary diseases in the French population -is inserted, in spite of its diet rich in fats, due to the moderate consumption of red wine…”

mentioning

confidence: 99%

Use of Resveratrol in Cardiovascular Diseases Prevention: A Systematic Review

Góes

Fraga

Ladeia

2017

BJMHH

View full text Add to dashboard Cite

| Resveratrol, a polyphenolic compound found in blackberry and red wine, has properties that prevent the development of atherosclerosis, and therefore, cardiovascular disease. The aim of this study was, through a systematic review, to assess whether resveratrol reduces the incidence of cardiovascular events and improves inflammation and endothelial dysfunction in individuals at risk. Searches were conducted in databases such as LILACS, PubMed,SCIELO and selected randomized controlled trials in humans, including the use of resveratrol in the prevention of cardiovascular events or in the improvement of inflammation and endothelial function. The final sample consisted of 10 items. Of the four studies that analyzed the flow-mediated dilatation of the brachial artery, all showed significant improvement in endothelial function after the use of resveratrol, compared with placebo. In the 7 studies that evaluated subclinical inflammation, there were differences, 3 studies showed significant decreases in the values of TNF-α, 2 showed significant changes in plasma levels of C-reactive protein and interleukin 6 (IL-6), while 1 didn't showed changes in TNF-α and IL-6. In conclusion, resveratrol is capable of improving endothelial function when compared with placebo. However, it was not possible to infer an improvement or not in the parameters concerning endothelial inflammation, since the data extracted from the studies were insufficient. Moreover, it was not possible to evaluate the use of resveratrol in the improvement of survival, infarction or reduction in mortality, since there were no records in the literature of randomized controlled trials that analyzed the effect of resveratrol use on clinical outcomes in humans.

show abstract

“…For examples, a significant reduction in total cholesterol, blood pressure (both SBP and DBP), glucose, and insulin has been shown in obese individuals taking 300 mg or more of resveratrol per day [18]. There is also evidence to support its therapeutic potential for management of congestive heart failure [19] and protection against neurodegenerative disease such as AD [20].…”

Section: Introductionmentioning

confidence: 99%

“…Potential benefit from regular dietary supplement of resveratrol for prevention of cardiometabolic disease and AD has been shown recently in several clinical trials [17,18]. For examples, a significant reduction in total cholesterol, blood pressure (both SBP and DBP), glucose, and insulin has been shown in obese individuals taking 300 mg or more of resveratrol per day [18].…”

Section: Introductionmentioning

confidence: 99%