This study examines sustainable agricultural development in Vietnam by focusing on rice production in the Mekong Delta. Vietnam is the third largest rice-exporting country in the world and more than 90% of rice for export is from the Mekong Delta. We attempt to identify changes in the rice industry, specifically examining farming mechanization, trends in farm operation, and farm household economy. The main structure of our study is based on our direct interviews with 420 farmer households, 81 registered large farm owners, 75 farming service providers, and local government members. We carried out those interviews in 2013 and 2014. We identified several important changes brought by technological advances, economic modernization, government policies, and environmental movements. One important finding was the increasing trend of agricultural land per farmer household, such as from 1.98 to 2.27 ha in 2010 to 2018, and the decreasing trend of labor force, which pushed up agricultural mechanization. Another point was the land law revised in 2013, which allowed farmers to borrow (no private land ownership in Vietnam) farms up to 30ha/household if registered as a “Trang Trai” farm. Farmers accepted the use of tractors and combine harvesters; however, rice seed sowing was not mechanized, so rice transplanters were rarely used for rice planting. Among the processes of rice production, sowing of rice seeds was the least mechanized. In order to achieve more sustainable agricultural practices, we recommend improving the mechanization of the rice seed sowing process for the Mekong Delta farmers with acceptable conditions. Another finding was positive movements among Mekong Delta researchers and farmers to improve their rice quality to be accepted as high-quality rice in the global rice market and to dispel the bad reputation of the past.