The effects of rilmenidine on tests of autonomic function in humans

McKaigue, James P.; Harron, D. W. G.

doi:10.1038/clpt.1992.179

Cited by 25 publications

(5 citation statements)

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“…Overall, our findings in hypertensive patients support the view that both rilmenidine and atenolol attenuate sympathetic and enhance cardiac parasympathetic tone as previously shown in normotensive volunteers [10,26].…”

Section: Autonomicfunction Testssupporting

confidence: 79%

“…been shown that rilmenidine exerts similar effects in Double-blind comparative studies vs atenolol, hydroexperimental animals [8,9]. Furthermore, in normal activity, rilmenidine enhanced parasympathetic tone as assessed by heart rate (HR) changes immediately after standing and deep breathing and blunted the reflex increase in sympathetic activity after standing for 3 min [10]. However, these effects have not been reported so far in hypertensive patients.…”

Section: Introductionmentioning

confidence: 90%

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The effects of rilmenidine and atenolol on mental stress, dynamic exercise and autonomic function in mild to moderate hypertension.

Panfilov¹,

Morris²,

Donnelly³

et al. 1995

Brit J Clinical Pharma

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1 The effects of 4 week treatment with rilmenidine or atenolol on tests of mental stress, dynamic exercise, autonomic function and psychometric tests were evaluated in a randomized, double-blind, placebo-controlled, cross-over study. Keywords rilmenidine atenolol hypertension mental stress dynamic exercise autonomic function psychomotor tests Introduction an equivalent efficacy of rilmenidine and a satisfactory safety profile. These comparisons have revealed minimal Rilmenidine is an oxazoline derivative and a new antihy-central side effects of rilmenidine, considerably less than pertensive drug with a central action that is probably those of clonidine [5][6][7]. more dependent on its high specificity for imidazolineThe antihypertensive effect of centrally active drugs, receptor sites than a2-adrenoceptor agonist actions [1]. such as clonidine is related to a reduction in sympathetic It has been shown to reduce blood pressure (BP) both outflow and enhanced parasympathetic activity. It has in healthy subjects [2,3] and hypertensive patients [4]. been shown that rilmenidine exerts similar effects in Double-blind comparative studies vs atenolol, hydroexperimental animals [8,9]. Furthermore, in normal

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Section: Autonomicfunction Testssupporting

confidence: 79%

Section: Introductionmentioning

confidence: 90%

The effects of rilmenidine and atenolol on mental stress, dynamic exercise and autonomic function in mild to moderate hypertension.

Panfilov¹,

Morris²,

Donnelly³

et al. 1995

Brit J Clinical Pharma

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“…Рилменидин имеет большее сродство с имидазолиновыми рецепторами [16]. По сравнению с клонидином, он более эффективно снижает АД, а число нежелательных явлений наблюдается намного реже [17]. При сравнении рилменидина с атенололом, первый вызывал такое же снижение АД‚ но переносимость его оказалась лучше.…”

Section: симпатолитики центрального действия альфаадреноблокаторыunclassified

Sympathetic hyperactivity in patients with hypertension: pathogenesis and treatment. Part II

Safaryan¹,

Саргсян²

2021

Cardiovasc Ther Prev

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“…These arrhythmias usually occur in patients with left ventricular hypertrophy. They may result in sudden death 11–14 …”

Section: Central Anti‐arrhythmic Effectsmentioning

confidence: 99%

Does It Make Sense To Develop New Centrally Acting Cardiovascular Drugs?

Bousquet

Monassier

Feldman

2001

Clin Exp Pharma Physio

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1. The autonomic nervous system plays a pivotal role in modulating all the components of the cardiovascular regulation. Therefore, one can assume that drugs targeting this system may be useful in the management of several cardiovascular diseases. 2. Drugs acting on central nervous system centres seem to be modulators rather than blockers; as such, they are expected to preserve the contraregulatory processes and to generate only a few side effects. 3. Because the sympathetic nervous system is largely involved in the regulation of vasomotor tone, centrally acting antihypertensive drugs were developed first. 4. Recently, new leader compounds selective for non- adrenergic imidazoline recepetors have been synthetized. Although such drugs have no capacity to activate alpha2-adrenoceptors, they have been proven to be hypotensive. These drugs are expected to be even better tolerated than the currently available centrally active drugs. They may also have additional beneficial effects. 5. Here, the experimental evidence suggesting that such drugs may be useful in the management of some cardiac arrhythmias and/or left ventricular dysfunction will be reviewed.

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The effects of rilmenidine on tests of autonomic function in humans

Cited by 25 publications

References 0 publications

The effects of rilmenidine and atenolol on mental stress, dynamic exercise and autonomic function in mild to moderate hypertension.

The effects of rilmenidine and atenolol on mental stress, dynamic exercise and autonomic function in mild to moderate hypertension.

Sympathetic hyperactivity in patients with hypertension: pathogenesis and treatment. Part II

Does It Make Sense To Develop New Centrally Acting Cardiovascular Drugs?

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