The effects of rosiglitazone and metformin on menstrual cyclicityand hirsutism in polycystic ovary syndrome

Yılmaz, Murat; Karakoç, Ayhan; Törüner, Füsun Baloş; Çakır, Nuri; Tıraş, Bülent; Ayvaz, Göksün; Arslan, Metin

doi:10.1080/09513590500231627

Cited by 72 publications

(62 citation statements)

References 44 publications

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“…However, the estimated cost of glargine was $216 for 24 weeks, yet the average monthly cost of a vial is $70 (5). This results in a total cost of glargine therapy of $420 for 24 weeks.…”

Section: Marc De Hert MDmentioning

confidence: 99%

“…Finally, such a combination may also provide some help to tackle other metabolic abnormalities of PCOS, like hirsutism and glucose intolerance (5,6 R osenstock et al (1) reported on the safety and efficacy of add-on insulin glargine versus rosiglitazone for patients with type 2 diabetes not adequately controlled on dual oral therapy with sulfonylurea plus metformin. The main finding of the study was similar glycemic control in both groups.…”

Section: Marc De Hert MDmentioning

confidence: 99%

“…We have recently reported on five patients with treatment-emergent diabetes who were successfully switched to a more suitable antipsychotic, which resulted in the reversal of diabetes (to risperidone in one patient [4] and amisulpride in four patients [5]). Since aripiprazole, a second-generation antipsychotic agent described as having a good metabolic profile (6 -8), became available on the Belgian market, all consecutive patients with recently detected diabetes were switched to this agent.…”

mentioning

confidence: 99%

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Ovarian Stockpiling in Polycystic Ovary Syndrome, Infertility, and the Combined Use of Rosiglitazone and Metformin

Elhadd¹,

Fiad²,

Meer³

2006

Diabetes Care

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“…However, the estimated cost of glargine was $216 for 24 weeks, yet the average monthly cost of a vial is $70 (5). This results in a total cost of glargine therapy of $420 for 24 weeks.…”

Section: Marc De Hert MDmentioning

confidence: 99%

Section: Marc De Hert MDmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Ovarian Stockpiling in Polycystic Ovary Syndrome, Infertility, and the Combined Use of Rosiglitazone and Metformin

Elhadd¹,

Fiad²,

Meer³

2006

Diabetes Care

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“…Coadministration of pioglitazone with IGF-1 (5) might be a more optimal treatment strategy for patients with such extreme syndromes. We have recently reported on five patients with treatment-emergent diabetes who were successfully switched to a more suitable antipsychotic, which resulted in the reversal of diabetes (to risperidone in one patient [4] and amisulpride in four patients [5]). Since aripiprazole, a second-generation antipsychotic agent described as having a good metabolic profile (6 -8), became available on the Belgian market, all consecutive patients with recently detected diabetes were switched to this agent.…”

Section: Angela Napolimentioning

confidence: 99%

“…The central afferent visual function was evaluated via the delay of the major positive component (P100) of the visualevoked potentials that was generated following a pattern-reversal checkboard stimulation (5). Cardiovascular autonomic function was assessed by means of the five standard cardiovascular reflex tests (2,3,6).…”

mentioning

confidence: 99%

Antihypertensive Medications and the Risk of Incident Type 2 Diabetes

Taylor

Curhan

2006

Diabetes Care

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Is there a relationship?I t became clear in the last decades that neuropathy is not a separate clinical entity, but a component of several related complications (1). Although the functional consequences of neuropathy are well defined in various organ systems, the relationship of the alterations in the networks of the neuronal system is still poorly documented. Assessment of the potential common alterations of the different neuronal functions in patients with diabetic neuropathy may provide new pathogenetic and diagnostic considerations. Previously, we observed correlations between the delay of certain auditory-evoked potentials and the severity of autonomic and peripheral sensory neuropathy in patients with type 1 diabetes (2). In addition, we found a relationship between the latency of visual-evoked potentials and the peripheral neuronal function (3). The aims of this study were to analyze the possible correlations between the central auditory and visual afferentations and the severity of autonomic and sensory neuropathy in patients with long-standing type 1 diabetes.A total of 10 middle-aged type 1 diabetic patients with long-standing diabetes were included in the study (4 male and 6 female subjects aged 43.8 Ϯ 15.2 years [mean Ϯ SD], duration of diabetes 23.1 Ϯ 9.3 years, BMI 27.9 Ϯ 3.9 kg/m 2 ). Patients with abnormal hearing, proliferative retinopathy, impaired visual acuity, or neuropathy of origin other than diabetes were excluded. The quantitative characteristics of the brainstem function were evaluated by the detection of auditoryevoked potentials after the delivery of an audible click of short duration via an earphone (4). The latencies of the first five waves (I-V) were analyzed in this study.The central afferent visual function was evaluated via the delay of the major positive component (P100) of the visualevoked potentials that was generated following a pattern-reversal checkboard stimulation (5). Cardiovascular autonomic function was assessed by means of the five standard cardiovascular reflex tests (2,3,6). The heart rate tests (the heart rate response to deep breathing, the 30:15 ratio, and the Valsalva ratio) mainly reflect the parasympathethic function, whereas the systolic blood pressure response to standing up and the diastolic pressure change to a sustained handgrip predominantly characterize the sympathetic integrity. Detection of current perception thresholds (CPTs) with a neuroselective transcutaneous stimulator, the Neurometer (Neurotron, Baltimore, MD), allowed for the assessment of the sensory function at three different frequencies on the median and peroneal nerves (6). The analysis of the auditoryevoked potentials revealed negative relationships between the heart rate tests and the prolongation of the latencies of waves III and V (heart rate response to breathing-wave III, r ϭ Ϫ0.586, P Ͻ 0.01; 30:15 ratio-wave III, r ϭ Ϫ0.588, P Ͻ 0.01; heart rate response to breathingwave V, r ϭ Ϫ0.498, P Ͻ 0.05; Valsalva ratio-wave V, r ϭ Ϫ0.463, P Ͻ 0.05; and 30:15 ratio-wave V, r ϭ Ϫ0.599, P Ͻ 0...

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Interventions for hirsutism (excluding laser and photoepilation therapy alone)

Zuuren

Fedorowicz

Carter

et al. 2015

Cochrane Database of Systematic Reviews

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The effects of rosiglitazone and metformin on menstrual cyclicityand hirsutism in polycystic ovary syndrome

Abstract: Our data show that both metformin and rosiglitazone improve ovarian function and hirsutism in patients with PCOS. Rosiglitazone appears better than metformin in the treatment of hirsutism and has better patient tolerance.

Cited by 72 publications

References 44 publications

Ovarian Stockpiling in Polycystic Ovary Syndrome, Infertility, and the Combined Use of Rosiglitazone and Metformin

Ovarian Stockpiling in Polycystic Ovary Syndrome, Infertility, and the Combined Use of Rosiglitazone and Metformin

Antihypertensive Medications and the Risk of Incident Type 2 Diabetes

Interventions for hirsutism (excluding laser and photoepilation therapy alone)

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