1996
DOI: 10.1111/j.1476-5381.1996.tb15750.x
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The effects of (RS)‐α‐cyclopropyl‐4‐phosphonophenylglycine ((RS)‐CPPG), a potent and selective metabotropic glutamate receptor antagonist

Abstract: 1 In this study we describe the potent antagonist activity of a novel metabotropic glutamate (mGlu) receptor antagonist (RS)-cx-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG) which exhibits selectivity for mGlu receptors (group II and III) negatively coupled to adenylyl cyclase in the adult rat cortex. 4 In the rat cerebral cortex, (RS)-CPPG is the most potent antagonist of group II/III mGlu receptors yet described (with 20 fold selectivity for group III mGlu receptors), having negligible activity at group I… Show more

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Cited by 79 publications
(48 citation statements)
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“…Pretreatment with 200 M CPPG, an antagonist of group III mGluRs (Toms et al, 1996;Evans et al, 2000;Awatramani and Slaughter, 2001), significantly attenuated the effects of L-AP-4 (50 M), consistent with the mediation by group III mGluRs ( p Ͻ 0.01; n ϭ 6; ANOVA followed by a Bonferroni procedure for multiple comparisons) (Fig. 1 D).…”
Section: Group III Mglurs Modulate Excitatory Transmission In Lateralmentioning
confidence: 48%
“…Pretreatment with 200 M CPPG, an antagonist of group III mGluRs (Toms et al, 1996;Evans et al, 2000;Awatramani and Slaughter, 2001), significantly attenuated the effects of L-AP-4 (50 M), consistent with the mediation by group III mGluRs ( p Ͻ 0.01; n ϭ 6; ANOVA followed by a Bonferroni procedure for multiple comparisons) (Fig. 1 D).…”
Section: Group III Mglurs Modulate Excitatory Transmission In Lateralmentioning
confidence: 48%
“…We employed available pharmacological tools to attempt to distinguish between these two receptors. CPPG, a group III mGluR-preferring antagonist (Toms et al, 1996) was employed to confirm that this effect of L-AP4 is mediated by group III mGluRs. Preapplication of 100 M CPPG inhibited the L-AP4-induced suppression of excitatory transmission in SNc neurons (predrug amplitude: Ϫ193.54 Ϯ 29.3 pA, mean Ϯ S.E.M.…”
Section: Resultsmentioning
confidence: 99%
“…At high concentrations, LY341495 blocks all mGluRs; the IC 50 is Ͻ5 M for all but one of the mGluRs (25 M for mGluR4) (reviewed in Schoepp et al 1999). CPPG is a potent antagonist for group III and group II mGluRs, with an IC 50 of 2.2 and 46.2 nM, respectively, with little effects on group I mGluRs (Toms et al 1996). The cocktail of mGluR antagonists (20 M LY341495 plus 10 M CPPG) is likely to block the majority of mGluRs.…”
Section: Endogenous Mglur Activity Suppresses Gaba Release At Nmmentioning
confidence: 99%