The effects of rutin on cisplatin induced oxidative retinal and optic nerve injury: an experimental study

Taşlı, Nurdan Gamze; Uçak, Turgay; Karakurt, Yücel; Çimen, Ferda Keskin; Bilgin, Asli Ozbek; Kurt, Nezahat; Süleyman, Halis

doi:10.1080/15569527.2018.1442842

Cited by 28 publications

(18 citation statements)

References 27 publications

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“…Importantly, some chemotherapeutics, such as cisplatin and oxaliplatin, exhibit oxidative traits. In the case of oxaliplatin, this ability is proven to be linked to the pathogenesis of CIPN [ 65 , 66 , 67 ]. Should the observations be applied to CIPN caused by other types of chemotherapy, vitamin E could constitute a potentially excellent treatment option in this type of peripheral neuropathy.…”

Section: Vitamin Ementioning

confidence: 99%

Dietary Supplements in Chemotherapy-Induced Peripheral Neuropathy: A New Hope?

Szklener

Michalski

et al. 2022

Nutrients

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Chemotherapy-induced peripheral neuropathy (CIPN) is one of the main and most prevalent side effects of chemotherapy, significantly affecting the quality of life of patients and the course of chemotherapeutic treatment. Nevertheless, despite its prevalence, the management of the CIPN is considered particularly challenging, with this condition often being perceived as very difficult or even impossible to prevent with currently available agents. Therefore, it is imperative to find better options for patients diagnosed with this condition. While the search for the new agents must continue, another opportunity should be taken into consideration—repurposing of the already known medications. As proposed, acetyl-L-carnitine, vitamins (group B and E), extracts of medical plants, including goshajinkigan, curcumin and others, unsaturated fatty acids, as well as the diet composed of so-called “sirtuin-activating foods”, could change the typical way of treatment of CIPN, improve the quality of life of patients and maintain the continuity of chemotherapy. This review summarizes currently available data regarding mentioned above agents and evaluates the rationale behind future research focused on their efficacy in CIPN.

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Section: Vitamin Ementioning

confidence: 99%

Dietary Supplements in Chemotherapy-Induced Peripheral Neuropathy: A New Hope?

Szklener

Michalski

et al. 2022

Nutrients

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“…The clinical usage of CP is restricted due to its severe dose‐dependent side effects (Bayindir et al, ; Eid, Abdelkader, Abd El‐Raouf, Fawzy, & El‐Denshary, ). Previous research showed that CP treatment caused damage to many tissues and organ systems, such as reproductive toxicity (Kaya et al, ), nephrotoxicity (Masuda, Inoue, Miyata, Mizuno, & Nanba, ), hepatotoxicity (Ciftci, Onat, & Cetin, ), ototoxicity (Bayindir et al, ), ocular toxicity (Taşlı et al, ) and neurotoxicity (Kaya, Ciftci, Cetin, Tecellioğlu, & Başak, ). Many previous studies on CP‐induced male reproductive system toxicity demonstrated that CP administration led to oxidative damage and apoptosis in testicular tissue, a decline in testes' weight, an increase in abnormal sperm rate and a decrease in sperm concentrations and motility (Aksu et al, ; Ciftci et al, ; Kaya et al, ; Saral et al, ).…”

Section: Introductionmentioning

confidence: 99%

Favourable effect of β‐glucan treatment against cisplatin‐induced reproductive system damage in male rats

et al. 2019

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The aim of this study was to investigate the potential beneficial effects of β‐glucan treatment against oxidative, histological and spermatological damage caused by cisplatin on the male reproductive system. Twenty‐eight Sprague Dawley male rats were used in the study. The rats were randomly divided into four equal‐sized groups: a control group, cisplatin group (7 mg/kg in a single‐dose cisplatin administered intraperitoneally), β‐glucan group (β‐glucan given at a dose of 50 mg kg−1 d−1 for 14 day) and a cisplatin plus β‐glucan group (cisplatin and β‐glucan administered together at the same dose). Cisplatin administration induced an increase in the level of thiobarbituric acid‐reactive substances, a lipid peroxidation indicator. It induced a decrease in enzymatic (superoxide dismutase, catalase and glutathione peroxidase) activities and nonenzymatic (reduced glutathione) antioxidant levels. In addition, cisplatin caused both histological and spermatological damage, as shown by a decrease in sperm motility and epididymal sperm concentrations and an increase in abnormal sperm rates. The β‐glucan treatment improved cisplatin‐induced oxidative, histological and spermatological damage. This study revealed that β‐glucan treatment provided prevention against male reproductive system damage caused by cisplatin. These preventative effects were likely due to its antioxidant properties.

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“…The etiology of the chemotherapeutic agent should be clarified in order to allow the discovery of new therapeutic drugs to modulate the chemotherapeutic agent-induced optic nerve oxidative damage. The results of recent studies indicate the involvement of chemotherapeutic agents-induced oxidative stress in the optic nerve oxidative injury in the rats (Icel et al 2018;Taşlı et al 2018;Özkaya and Nazıroğlu 2020).…”

Section: Recent Developments On the Chemotherapeutic Agents-induced Oxidative Injury In Optic Nervementioning

confidence: 99%

“…The hydrogen peroxide is converted to water by the catalytic actions of catalase and glutathione peroxidase. Hence, the decrease of the antioxidants such as glutathione and glutathione peroxidase were reported in the cisplatin-induced optic nerve injury of rats, although the decreases of antioxidants are modulated by the antioxidant treatments such as curcumin, Pycnogenol, and rutin (Icel et al 2018;Taşlı et al 2018;Özkaya and Nazıroğlu 2020). In the oral presentation, I will summarize recent developments on the chemotherapeutic agents-induced oxidative injury in optic nerve.…”

Section: Recent Developments On the Chemotherapeutic Agents-induced Oxidative Injury In Optic Nervementioning

confidence: 99%

Abstract Book of 6th International Brain Research School-21 and 27 June 2021, Isparta /TURKEY-http://2021.brs.org.tr

BOOK¹

2021

Journal of Cellular Neuroscience and Oxidative Stress

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Journal of Cellular Neuroscience and Oxidative Stress is an online journal that publishes original research articles, reviews and short reviews on the molecular basis of biophysical, physiological and pharmacological processes that regulate cellular function, and the control or alteration of these processes by the action of receptors, neurotransmitters, second messengers, cation, anions, drugs or disease.Areas of particular interest are four topics. They are;A-Ion Channels (Na + -K + Channels, Clchannels, Ca 2+ channels, ADP-Ribose and metabolism of NAD + , Patch-Clamp applications) B-Oxidative Stress (Antioxidant vitamins, antioxidant enzymes, metabolism of nitric oxide, oxidative stress, biophysics, biochemistry and physiology of free oxygen radicals) C-Interaction Between Oxidative Stress and Ion Channels in Neuroscience (Effects of the oxidative stress on the activation of the voltage sensitive cation channels, effect of ADP-Ribose and NAD + on activation of the cation channels which are sensitive to voltage, effect of the oxidative stress on activation of the TRP channels in neurodegenerative diseases such Parkinson's and Alzheimer's diseases) D-Gene and Oxidative Stress (Gene abnormalities. Interaction between gene and free radicals. Gene anomalies and iron. Role of radiation and cancer on gene polymorphism)

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The effects of rutin on cisplatin induced oxidative retinal and optic nerve injury: an experimental study

Cited by 28 publications

References 27 publications

Dietary Supplements in Chemotherapy-Induced Peripheral Neuropathy: A New Hope?

Dietary Supplements in Chemotherapy-Induced Peripheral Neuropathy: A New Hope?

Favourable effect of β‐glucan treatment against cisplatin‐induced reproductive system damage in male rats

Abstract Book of 6th International Brain Research School-21 and 27 June 2021, Isparta /TURKEY-http://2021.brs.org.tr

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