The effects of rutin supplement on blood pressure markers, some serum antioxidant enzymes, and quality of life in patients with type 2 diabetes mellitus compared with placebo

Abstract

BackgroundThis trial aimed to investigate the effects of rutin supplement in type 2 diabetes mellitus (T2DM) patients.MethodsIn this trial with a double-blind and controlled design, fifty patients were randomly divided into intervention (n = 25) and control groups (n = 25) and were treated with 1 g of rutin or placebo for three months, respectively. At the baseline and end of the intervention, mean arterial pressure (MAP), heart rate (HR), pulse pressure (PP), systolic and diastolic blood pressure (SBP and DBP), serum levels of antioxidant enzymes, such as catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) and quality of life (QOL) parameters, were evaluated.ResultsRutin consumption caused a significant reduction in SBP, DBP, PP, MAP, and HR, with a significant increase in SOD, CAT, and GPx and some QOL parameters (emotional limitations, energy and freshness, mental health, social performance, and general health) compared with baseline (p for all <0.05). Also, the mean changes of emotional limitations, energy and freshness, mental health, and general health (unadjusted p for all <0.05) and GPX and SOD (adjusted p for all <0.05) were significantly higher in the rutin group compared with the placebo group. Although, in the supplement group compared with the placebo group, the mean changes of SBP, DBP, MAP, PP, and HR were significantly lower (adjusted p for all <0.05).ConclusionRutin consumption improved blood pressure, the levels of antioxidant enzymes, and QOL in patients with T2DM.

Assessing the predictive value of insulin resistance indices for metabolic syndrome risk in type 2 diabetes mellitus patients

“…This procedure was iterated thrice consecutively, and the average of the three successive readings was utilized for analysis. The mean arterial pressure (MAP) and pulse pressure (PP) were calculated employing the following formulas 54 : where SBP represents systolic blood pressure and DBP represents diastolic blood pressure, both measured in millimeters of mercury (mmHg).…”

Exploring Beneficial Properties of Haskap Berry Leaf Compounds for Gut Health Enhancement

“…By complementing the antioxidant repertoire [ 14 , 15 ], rutin, a prominent bioactive compound found abundantly in haskap berry leaves, exhibits noteworthy anti-inflammatory effects contributing to its potential role in addressing diabetes progression and associated cardiovascular complications. The multifaceted properties of rutin make it a promising candidate for therapeutic applications in managing diabetes-related conditions [ 16 , 17 ]. Catechins, contributing to metabolic health, have been linked to improved metabolic parameters and modulation of the gut microbiota composition, influencing factors like insulin sensitivity and glucose metabolism [ 18 , 19 ].…”