The effects of salicylic acid and related compounds on in vitro rat brain respiration

Penniall, Ralph; Kalnitsky, George; Routh, Joseph I.

doi:10.1016/0003-9861(56)90283-1

Cited by 36 publications

(14 citation statements)

References 15 publications

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“…* Mean i SE. DISCUSSION Salicylate affects aerobic oxidative phosphorylation in differing ways, depending on the source of the tissue or the mitochondrial preparation (9)(10)(11)(12). In the present study, the increased respiratory rate of lymphocytes after the addition of salicylate was diminished to endogenous levels by cyanide, suggesting that salicylate stimulated aerobic-dependent activity.…”

Section: Experimental Designsupporting

confidence: 47%

“…and considered therapeutic at mg/100 ml, and symptomatic Pharmacological studies of the effect of salicylate on various tissues and mitochondria indicate that it uncouples oxidative phosphorylation (7)(8)(9)(10)(11), affecting primarily aerobic phosphorylation (12). Previous investigation of the carbohydrate metabolism of lymphocytes, one of the components of the inflammatory cycle, has shown that their oxidative phosphorylation could be uncoupled by 2,4-dinitrophenol (13).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of salicylate on the metabolism of normal and stimulated human lymphocytes in vitro

Pachman¹,

Esterly²,

Peterson³

1971

J. Clin. Invest.

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Section: Experimental Designsupporting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

The effect of salicylate on the metabolism of normal and stimulated human lymphocytes in vitro

Pachman¹,

Esterly²,

Peterson³

1971

J. Clin. Invest.

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“…In the liver salicylate levels, which in vitro are associated with complete inhibition of oxidative phosphorylation (2-5 mM) (11), were reached within 1-3 min. In homogenates and mitochondrial preparations of brain, 1-2 mm salicylate causes 50-100% uncoupling (11,12). In this study the salicylate concentration in the brain was 1.2 mm at 5 min.…”

Section: Resultsmentioning

confidence: 52%

Reduced brain glucose with normal plasma glucose in salicylate poisoning

Thurston¹,

Pollock²,

Warren³

et al. 1970

J. Clin. Invest.

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A BS T R A C T After the intraperitoneal injection into young mice of 700-800 mg/kg of salicylate, brain glucose fell to one-third or less of control values despite normal plasma glucose levels; brain lactate was nearly doubled and there were small decreases in phosphocreatine (18%) and in glycogen (17%). ATP, pyruvate, a-ketoglutarate, and glutamate were unchanged. In liver, glycogen was reduced 79% and lactate was five times higher than in control animals; glucose, glucose-6-phosphate, and ATP were unchanged.Since salicylate uncouples oxidative phosphorylation, it is postulated that high energy phosphate in the brain is maintained near normal levels by a compensatory increase in cerebral glycolysis. Apparently the brain glucose level falls because the rate of utilization exceeds the rate at which glucose can be supplied from the blood. Concurrent administration of glucose with salicylate elevated brain glucose concentration and was associated with striking improvement in the condition and the increased survival of the animals. These findings stress the fact that in salicylate poisoning the supply of glucose to the brain may be inadequate even when blood glucose levels are normal.

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“…Salicylate uncouples oxidative-phosphorylation reactions in respiring mitochondrial preparations (Brody, 1956;Penniall, Kalnitsky & Routh, 1956;Jeffrey & Smith, 1959;Packer, Austen & Knoblock, 1959). The increased oxygen consumption and diminished amounts of adenosine triphosphate and creatine phosphate observed in the isolated rat diaphragm incubated with salicylate (Smith & Jeffrey, 1956) are directly explicable in terms of this uncoupling action.…”

Section: Effects Of Salicylate and 2:4-dinitrophenol On The Incorporamentioning

confidence: 99%

Uncoupling reagents and metabolism. 1. Effects of salicylate and 2:4-dinitrophenol on the incorporation of 14C from labelled glucose and acetate into the soluble intermediates of isolated rat tissues

Smith¹,

Moses²

1960

Biochemical Journal

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The effects of salicylic acid and related compounds on in vitro rat brain respiration

Cited by 36 publications

References 15 publications

The effect of salicylate on the metabolism of normal and stimulated human lymphocytes in vitro

The effect of salicylate on the metabolism of normal and stimulated human lymphocytes in vitro

Reduced brain glucose with normal plasma glucose in salicylate poisoning

Uncoupling reagents and metabolism. 1. Effects of salicylate and 2:4-dinitrophenol on the incorporation of 14C from labelled glucose and acetate into the soluble intermediates of isolated rat tissues

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