The effects of serotonergic psychedelics in synaptic and intrinsic properties of neurons in layer II/III of the orbitofrontal cortex

Tang, Zi-Hang; Yu, Zhipeng; Li, Qiong; Zhang, Xiaoqin; Muhetaer, Kadeliya; Wang, Zhengchun; Xu, Peng; Shen, Haowei

doi:10.1007/s00213-023-06366-y

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…These findings corroborate previous reports on the impact of others NBOMe derivatives in synaptic transmission. For instance, it has already been shown that 25C-NBOMe to increase the excitability of pyramidal neurons in orbitofrontal cortex of adult rats [ 20 ]. Other studies reported that 25B-NBOMe and 25I-NBOMe increase the release of excitatory neurotransmitters in rat cortex, striatum, and nucleus accumbens [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Neurotoxic effects of hallucinogenic drugs 25H-NBOMe and 25H-NBOH in organotypic hippocampal cultures

Cassiano

Oliveira²,

Barros

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Neurotoxic effects of hallucinogenic drugs 25H-NBOMe and 25H-NBOH in organotypic hippocampal cultures

Cassiano

Oliveira²,

Barros

et al. 2023

Heliyon

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“…Empathy training in adolescents has been shown to cause increased activity in the temporoparietal junction. Interestingly, psilocybin has been associated with activity and increased neuroplasticity of the prefrontal cortex 36 , 37 , as well as in the temporal parietal junction 38 .…”

Section: Exploring the Relationship Between Empathy And Prosocial Beh...mentioning

confidence: 99%

The effect of psilocybin on empathy and prosocial behavior: a proposed mechanism for enduring antidepressant effects

Bhatt,

Weissman

2024

npj Mental Health Res

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Psilocybin is a serotonergic psychedelic shown to have enduring antidepressant effects. Currently, the mechanism for its enduring effects is not well understood. Empathy and prosocial behavior may be important for understanding the therapeutic benefit of psilocybin. In this article we review the effect of psilocybin on empathy and prosocial behavior. Moreover, we propose that psilocybin may induce a positive feedback loop involving empathy and prosocial behavior which helps explain the observed, enduring antidepressant effects.

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Psilocybin prevents habituation to familiar stimuli and preserves sensitivity to sound following repeated stimulation in mouse primary auditory cortex

Lane,

Tarka,

Valentin

et al. 2024

Preprint

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Psilocybin, a psychoactive substance derived from fungi, has been utilized historically by diverse cultures for both medicinal and non-medicinal purposes, owing to its ability to elicit profound sensory and cognitive alterations and sustain long-term changes in mood and cognition. Promising results from recent clinical studies have generated a wave of interest in employing psilocybin to treat neuropsychiatric and neuro-degenerative conditions. How psychedelics cause acute perceptual effects, and how these relate to long-lasting alterations is still debated. Whereas it is thought that perceptual disturbances may be caused by disrupted flow of information between sensory and higher order areas, in vivo studies have focused mostly on the latter. In particular, there has been little study of how psilocybin affects sensory representations in primary auditory cortex (A1). We used two-photon microscopy and wide field calcium imaging to examine how psilocybin affects A1 neuron response properties in the mouse. Administration of 1 mg/kg psilocybin prevented habituation of sound-evoked responses to repeated stimuli, maintaining overall responsiveness, bandwidth, and sound-level response thresholds after repeated stimulation. This was in contrast to marked habituation of responses and narrowing of tuning in controls. We observed no effect on overall distribution of best frequencies at the cortical level, suggesting psilocybin in A1 disrupts normal sensory gating, rather than tonotopic organization. This supports models of psychedelic action in which perceptual disturbances are driven by disrupted hierarchical sensory gating. With further research, influences of psychedelics on sensory representations could be harnessed to target maladaptive sensory processing in conditions such as tinnitus.

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The effects of serotonergic psychedelics in synaptic and intrinsic properties of neurons in layer II/III of the orbitofrontal cortex

Cited by 3 publications

References 41 publications

Neurotoxic effects of hallucinogenic drugs 25H-NBOMe and 25H-NBOH in organotypic hippocampal cultures

Neurotoxic effects of hallucinogenic drugs 25H-NBOMe and 25H-NBOH in organotypic hippocampal cultures

The effect of psilocybin on empathy and prosocial behavior: a proposed mechanism for enduring antidepressant effects

Psilocybin prevents habituation to familiar stimuli and preserves sensitivity to sound following repeated stimulation in mouse primary auditory cortex

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