The Effects of Sesamin Supplementation on Obesity, Blood Pressure, and Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Sun, Yiting; Ren, Jingyi; Zhu, Siqi; Zhang, Zhenao; Guo, Zihao; An, Jiaqi; Yin, Bowen; Ma, Yun‐Bao

doi:10.3389/fendo.2022.842152

Cited by 6 publications

(7 citation statements)

References 57 publications

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“…Two meta-analyses 96,98 detected a significant decrease in systolic blood pressure associated with sesame intake, compared with controls, but found no consistent effect on diastolic blood pressure. A similar outcome was observed in the analysis of studies with supplemental sesamin 97 . In addition, as reported in 3 meta-analyses, 96,97,99 the effect of sesame and sesamin on body weight and body mass index was inconsistent.…”

Section: Methodssupporting

confidence: 76%

“…There was no agreement as to whether sesame intake significantly influenced total cholesterol, low-density lipoprotein, and high-density lipoprotein values. In contrast, a recent meta-analysis of randomized controlled trials determined that consumption of sesamin supplements significantly reduced serum total cholesterol and low-density lipoprotein levels but did not affect triglyceride and high-density lipoprotein 97 …”

Section: Methodsmentioning

confidence: 88%

“…A similar outcome was observed in the analysis of studies with supplemental sesamin. 97 In addition, as reported in 3 meta-analyses, 96,97,99 the effect of sesame and sesamin on body weight and body mass index was inconsistent.…”

Section: Potential Health Benefits Of Sesame In Human Trialsmentioning

confidence: 99%

“…In contrast, a recent metaanalysis of randomized controlled trials determined that consumption of sesamin supplements significantly reduced serum total cholesterol and low-density lipoprotein levels but did not affect triglyceride and high-density lipoprotein. 97 Two meta-analyses 96,98 detected a significant decrease in systolic blood pressure associated with sesame intake, compared with controls, but found no consistent effect on diastolic blood pressure. A similar outcome was observed in the analysis of studies with supplemental sesamin.…”

Section: Potential Health Benefits Of Sesame In Human Trialsmentioning

confidence: 99%

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Sesame

Singletary¹

2022

Nutr Today

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Sesame (Sesamum indicum L.) is an annual plant whose seeds are purported to be one of the oldest oilseeds used by humans. Although originating in Africa and India, this plant currently is cultivated in diverse regions worldwide from semiarid tropics to temperate areas. This edible seed oil has many routine and diverse uses in food preparation and cooking, and the dehulled seed is included in the preparation of numerous food products, condiments, and confectionaries, imparting a distinctive savory, nutty, roasted flavor. Sesame has a long history of use in traditional medicines for treatment of wounds, asthma, blurred vision, abdominal pain and ulcers, toothaches and gum disease, and migraine, to name a few. More recently, sesame constituents have demonstrated antioxidant and anti-inflammatory properties that may alleviate conditions such as atherosclerosis, diabetes, hypertension, and pain. The current narrative summarizes human studies evaluating sesame seeds, oil, and constituents for improving diverse human disorders, and provides suggestions for future research. Nutr Today 2022;57(5):271-287 S esame (Sesamum indicum L., family Pedaliaceae), also known as sesamum, gingelly, til, goma, ajonjoli, and benniseed, is an annual plant (Figure 1). The seeds are purported to be one of the oldest oilseeds used by humans. The seed colors of this plant vary considerably including white, yellow, gray, brown, and black, depending on the variety and strain of S indicum. Black sesame seeds and white sesame seeds are the most available worldwide.Although the chemical differences among the various colored sesame seeds are not well characterized, it has been reported that the contents of indole-3-carboxylic acid, hesperidin, 2-methoxycinnamic acid, vitamin B2, and hyoscyamine are significantly higher in black seeds compared with white seeds. However, at least for sesame lignans, seed color and content of these bioactives are unrelated. 1,2 Although apparently originating in Africa and India, this plant is currently cultivated in diverse regions worldwide from semiarid tropics to temperate areas, and India, China, Tanzania, Sudan, and Myanmar are considered the major producers. Because of the high content of oil, sesame seed is called the queen of oilseeds. Its major use is the production of a notably oxidative rancidity-resistant oil. This oil has numerous uses such as a solvent, a hydrophobic vehicle for drug delivery, and a skin softener, and in the preparation of soaps and margarines. [2][3][4][5][6][7] In cosmetics, it can function as a binder, emulsifier, and viscosity-increasing agent. 8 As an edible seed oil, it has many routine and diverse uses in food preparation. It has widespread use globally in salads, and in Asia, the seed and oil are routinely used in cooking. Some Europeans substitute it for olive oil in cooking. The dehulled seed is included in the preparation of numerous food products, condiments, and confectionaries, imparting a distinctive savory, nutty, roasted flavor. For example, besides being sprinkled on ...

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Section: Methodssupporting

confidence: 76%

Section: Methodsmentioning

confidence: 88%

Section: Potential Health Benefits Of Sesame In Human Trialsmentioning

confidence: 99%

Section: Potential Health Benefits Of Sesame In Human Trialsmentioning

confidence: 99%

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Sesame

Singletary¹

2022

Nutr Today

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“…Continuous data on mean difference and standard deviation were obtained from the selected 9 publications by the authors as follows: mean difference in plaque index (the baseline and end intervention) and standard deviations (SD); mean difference in the gingival index (the baseline and end intervention) and standard deviations (SD); mean difference in oral health knowledge (the baseline and end intervention) and standard deviations (SD); mean difference in oral health attitude (the baseline and end intervention) and standard deviations (SD); and mean difference in oral health practice (the baseline and end intervention) and standard deviations (SD). The SD of the difference was calculated using the formula reported by Sun et al [ 31 ] The analysis of outcomes in this study was indicated by total and subgroups for developmental stages in the plaque index, gingival index, and the oral health KAP. A P value < .05 was considered significant.…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of e-learning to promote oral health education: A systematic review and meta-analysis

Kaneyasu,

Shigeishi,

Sugiyama

et al. 2023

Medicine

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Background: In recent times during and after the COVID-19 pandemic, e-learning is increasingly being used to give oral health education. However, the efficacy of e-learning in improving and promoting the oral hygiene and oral health knowledge, attitude and practice is unclear. Therefore, this systematic review and meta-analysis aim to clarify the effectiveness of e-learning compared to other conventional education methods for providing oral health. Methods: An electronic database search was performed on PubMed-Medline, Scopus, and CENTRAL (Central Register Cochrane of Controlled trials). Randomized controlled trials (RCTs), including cluster or group RCTs, were collected in this study. The risk of bias was assessed with the Cochrane Handbook for Systematic Reviews of Interventions. Five different meta-analyses were conducted for plaque index, gingival index, oral health knowledge, oral health attitude, and oral health practice using a random effects model. Results: A total of 282 articles were found through the database search; 19 articles were included in the qualitative synthesis and 9 articles in the quantitative synthesis. The meta-analysis found that compared with conventional education, e-learning exhibited no positive effect. However, the use of e-learning was superior to conventional education methods for oral health practice for adults in subgroup analysis. Conclusions: This paper could not indicate the effectiveness of e-learning in comparison with conventional education for oral health in total. However, for adults, it may be effective to get the oral health practice compared to the conventional education. Our study limitation is that there are only few studies that have assessed the effectiveness of e-learning. Therefore, numerous further high-quality studies should be conducted regarding the efficacy of e-learning compared with conventional education methods for oral health promotion.

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Dietary (poly)phenols and cardiometabolic health: from antioxidants to modulators of the gut microbiota

Rodriguez-Mateos,

Le Sayec,

Cheok

2024

Proc. Nutr. Soc.

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(Poly)phenols are plant secondary metabolites widely abundant in plant foods and beverages comprising a very large number of compounds with diverse structure and biological activities. Accumulating evidence indicates that these compounds exert beneficial effects against cardiometabolic diseases, and this review will provide a summary of current knowledge in this area. Epidemiological and clinical data collectively suggest that intake of flavonoids reduces the risk of cardiovascular disease (CVD), with the evidence being particularly strong for the flavan-3-ol subclass. However, to provide adequate dietary recommendations, a better understanding of their estimated content in foods and intake among the general public is needed. Regarding mechanisms of action, we now know that it is unlikely that (poly)phenols act as direct antioxidants in vivo, as it was hypothesised for decades with the popularity of in vitro antioxidant capacity assays. One of the reasons is that upon ingestion, (poly)phenols are extensively metabolised into a wide array of circulating metabolites with different bioactivities than their precursors. Well-conducted in vitro and in vivo studies and human nutrigenomic analysis have revealed new molecular targets that may be underlying the health benefits of (poly)phenols, such as the nitric oxide pathway. Recently, a bi-directional relationship was established between (poly)phenols and the gut microbiota, suggesting that individual gut microbial metabolising capacity may be a key factor explaining the variability in the cardiometabolic response to (poly)phenols. Future research is needed to elucidate which are the key factors affecting such capacity, and whether it can be modulated, along with the mechanisms of action.

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The Effects of Sesamin Supplementation on Obesity, Blood Pressure, and Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Cited by 6 publications

References 57 publications

Sesame

Sesame

Effectiveness of e-learning to promote oral health education: A systematic review and meta-analysis

Dietary (poly)phenols and cardiometabolic health: from antioxidants to modulators of the gut microbiota

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