The effects of sewage treatment plant effluents on hepatic and intestinal biomarkers in common carp (Cyprinus carpio)

Sakalli, Sidika; Giang, Phạm Thái; Burkina, Viktoriia; Zamaratskaia, Galia; Rasmussen, Martin Krøyer; Bakal, Tomas; Tilami, Sarvenaz Khalili; Sampels, Sabine; Kolářová, Jitka; Grabic, Roman; Turek, Jan; Randák, Tomáš; Žlábek, Vladimír

doi:10.1016/j.scitotenv.2018.04.188

Cited by 25 publications

(8 citation statements)

References 78 publications

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“…These type of pollutants are being detected in drinking water, groundwater and surface water at concentrations ranging from ng•L -1 to mg•L -1 [1,2]. Even at these concentrations, they can pose a threat to aquatic environments and human health [1,3,4]. Sources of water contamination with ECs are sewage effluents from domestic and industrial facilities and industrial effluent discharges.…”

Section: Introductionmentioning

confidence: 99%

Influence of TIO2-rGO optical properties on the photocatalytic activity and efficiency to photodegrade an emerging pollutant

Tolosana-Moranchel

Manassero

Satuf

et al. 2019

Applied Catalysis B: Environmental

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TiO 2 -reduced graphene oxide (TiO 2 -rGO) photocatalysts with different mass ratios (GO:TiO 2 0.1-0.5-1%) were synthesized via a hydrothermal method and compared through their physico-chemical properties and photocatalytic activity in the degradation of an emerging contaminant, clofibric acid. The optical properties of the TiO 2 -rGO nanocomposites were first estimated in order to calculate the local volumetric rate of photon absorption inside a photocatalytic reactor. Radiation models were solved using the Monte Carlo method. The effect of rGO as well as the photocatalyst loadings on the radiation absorption was evaluated. The lowest photodegradation rate found in P25-rGO 1% was ascribed to an excess of rGO that could well favor charge carriers recombination leading to detrimental photoactivity. A GO/TiO 2 mass ratio of 0.5 % provided the fastest initial photodegradation rate under the operating conditions studied here. Finally, the photo-efficiency of all these photocatalysts was also analyzed by calculating the quantum efficiency parameter. The highest value of quantum efficiency was achieved with P25-rGO 0.5% at 100 mg L -1 , with an increase of 11% compared to the value obtained for P25-rGO 0%.

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Section: Introductionmentioning

confidence: 99%

Influence of TIO2-rGO optical properties on the photocatalytic activity and efficiency to photodegrade an emerging pollutant

Tolosana-Moranchel

Manassero

Satuf

et al. 2019

Applied Catalysis B: Environmental

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“…Fish exposed to environmental stressors, such as pharmaceuticals and personal care products, can have altered gut bacterial community and diversity. The gut content microbiome of adult fish (wild brown trout, Salmo trutta ; common carp, Cyprinus carpio ; and rainbow darter, Etheostoma caeruleum ) downstream of MMWE outfalls (containing mixtures of contaminants) had both decreased and increased alpha diversity, increased bacteria associated with MWWEs, and increased abundance of Proteobacteria compared to upstream fish; such changes have been linked to dysbiosis (microbial imbalance) and altered health outcomes (Giang et al 2018 ; Sakalli et al 2018 ; Restivo et al 2020 ). Metformin affects the intestinal microbiome of larval brown trout (Jacob et al 2018 ; Rogall et al 2020 ), and those exposed to metformin (up to 1000 µg/L) had shifts in Firmicutes, with the families Planococcacea disappearing and Staphlococcaceae increasing compared to controls (Rogall et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Chronic Embryo-Larval Exposure of Fathead Minnows to the Pharmaceutical Drug Metformin: Survival, Growth, and Microbiome Responses

Parrott

Restivo

Kidd

et al. 2021

Environmental Toxicology and Chemistry

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Metformin is a glucose-lowering drug commonly found in municipal wastewater effluents (MWWEs). The present study investigated the chronic effects of metformin in early-life stages of the fathead minnow (Pimephales promelas). Endpoints assessed were growth, survival, and deformities. The larval gut microbiome was also examined using 16 S ribosomal RNA gene amplicon sequencing to determine microbial community composition and alpha and beta diversity. Eggs and larvae were exposed to metformin measured concentrations (mean [standard deviation]) of 0.020 (0.017) μg/L (for controls) and 3.44 (0.23), 33.6 (1.6), and 269 (11) μg/L in a daily static-renewal setup, with 20 embryos per beaker. The low and middle metformin exposure concentrations represent river and MWWE concentrations of metformin. To detect small changes in growth, we used 18 replicate beakers for controls and 9 replicates for each metformin treatment. Over the 21-d exposure (5 d as embryos and 16 d posthatch [dph]), metformin did not affect survival or growth of larval fish. Hatch success, time to hatch, deformities in hatched fry, and survival were similar across all treatments. Growth (wet wt, length, and condition factor) assessed at 9 and 16 dph was also unaffected by metformin. Assessment of the microbiome showed that the larvae microbiome was dominant in Proteobacteria and Firmicutes, with small increases in Proteobacteria and decreases in Firmicutes with increasing exposure to metformin. No treatment effects were found for microbiome diversity measures. Control fish euthanized with the anesthetic tricaine methane sulfonate had decreased alpha diversity compared to those sampled by spinal severance. This experiment demonstrates that metformin at environmentally relevant concentrations (3.44 and 33.6 μg/L) and at 10 times MWWE concentrations (269 µg/L) does not adversely affect larval growth or gut microbiome in this ubiquitous freshwater fish species.

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“…Domestic STP effluents may contain mixtures of EDCs, such as natural (17β-estradiol, estrone and estriol) and synthetic estrogens (17α-ethinylestradiol, alkylphenol ethoxylates and bisphenol A) (Gorelick et al, 2014). Collectively, those EDCs that interact with estrogen receptors are known as environmental estrogens or xenoestrogens (Kerdivel et al, 2013), and their occurrence in STP effluent is strongly correlated with adverse physiological effects on fish (Sakalli et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Identification of receptors for eight endocrine disrupting chemicals and their underlying mechanisms using zebrafish as a model organism

Huang

Lin

et al. 2020

Ecotoxicology and Environmental Safety

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Herein, eight common endocrine disrupting chemicals (EDCs) were exposed to zebrafish (Danio rerio) to investigate the relationship between different EDCs and their activated estrogen receptors. Under acute exposure, we identified five major malformation types whose incidence and deformity modes differed among EDCs. Luciferase analysis divided the EDC receptors into four categories: (i) triclosan (TCS), 17ß-estradiol (E2) and estriol (E3) mainly activated GPER expression; (ii) bisphenol A (BPA), p-(tert-octyl) phenol (POP), 17α-ethynylestradiol (EE2), E2 and E3 activated ERβ expression; (iii) E2 and E3 acted on both GPER and ERβ; and (iv) estrone (E1) and 9,9-bis(4-hydroxyphenyl)fluorene (BHPF) had little effect on the two receptors. In vivo immunofluorescence experiments on 96-hpf larvae provided evidence that TCS and POP acted on GPER and ERβ, respectively, while E2 acted on the two receptors simultaneously. Luciferase activities in the promoter regions of gper (À 986 to À 488) and erβ (À 1998 to À 1496) were higher than those in other regions, identifying these key regions as targets for transcription activity. TCS promoted GPER expression by acting on the JUND transcription factor, while POP promoted ERβ expression by activating the Foxl1 transcription factor. In contrast, E2 mainly regulated transcription of GPER and ERβ by Arid3a. These findings provide compelling evidence that different EDCs possess varying estrogen receptors, leading to differential regulatory pathways and abnormality symptoms. These results offer an experimental strategy and fundamental information to assess the molecular mechanisms of EDC-induced estrogen effects.

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The effects of sewage treatment plant effluents on hepatic and intestinal biomarkers in common carp (Cyprinus carpio)

Cited by 25 publications

References 78 publications

Influence of TIO2-rGO optical properties on the photocatalytic activity and efficiency to photodegrade an emerging pollutant

Influence of TIO2-rGO optical properties on the photocatalytic activity and efficiency to photodegrade an emerging pollutant

Chronic Embryo-Larval Exposure of Fathead Minnows to the Pharmaceutical Drug Metformin: Survival, Growth, and Microbiome Responses

Identification of receptors for eight endocrine disrupting chemicals and their underlying mechanisms using zebrafish as a model organism

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