The Effects of Sildenafil Citrate on Ischemic Colonic Anastomotic Healing in Rats: Its Relationship Between Nitric Oxide and Oxidative Stress

Abstract

Our results suggest that sildenafil citrate may affect ischemic anastomotic healing due to its possible effects on nitric oxide metabolism and lipid peroxidation. However, functional implication of this agent further needs to be elucidated.

Does sildenafil have protective effects against ovarian ischemia-reperfusion injury in rats?

“…More recently, it has been used in the diseases induced by hypoxia, such as pulmonary hypertension, chronic heart failure and indomethacin-induced gastropathy, due to its features of vasodilation and the regulation of blood flow [8,10,18]. Additionally, there has been research that shows its protective effects due to its anti-oxidant features against IRD in tissues such as the heart, liver, lungs, kidney, colon and testicle [6,8,9,19,20]. It has been asserted that sildenafil regulates blood flow by increasing nitric oxide production, and decreases FOR by inhibiting leucocyte infiltration and adhesion [9,10].…”

The effects of Sildenafil in liver and kidney injury in a rat model of severe scald burn: A biochemical and histopathological study

“…However, unlike us, they evaluated the oxidant/antioxidant parameters in only tissue levels, whereas we evaluated them in both tissues and serum. Similarly, Uzun et al [34] Ulus Travma Acil Cerrahi Derg, September 2014, Vol. 20, No.…”

“…[23,[30][31][32][33][34]46,47] Histopathological evaluations of those studies also demonstrated the positive effects of various dosages of sildenafil administration (range 2±25 mg/kg) in decreased inflammation scores.…”

“…[20] Moreover, the beneficial effects of sildenafil have been shown in the balance of oxidation and antioxidation via decreasing oxidative and nitrosative stress in inflammatory events. [9,23,[30][31][32][33][34] However, there is no study in the literature focusing on the effects of sildenafil in remote organ injury induced by severe burn except our previous study focusing on acute lung injury. [9] The purpose of the present study was to evaluate the effects of different dosages of sildenafil in distant organs, such as liver and kidneys, due to severe scald burn injury in rats.…”

Comparison of Ferulic Acid and Sildenafil, Therapeutic Role against Testicular Injury Induced by Cadmium Chloride in Adult Male Albino Rat

“…It is also used in the treatment of the age-related diseases. [31,32]. It has been shown that inhibin-B is the only physiologically important hormone in rats and in men, [33].…”