The effects of sildenafil on the functional and structural changes of ileum induced by intestinal ischemia–reperfusion in rats

Soydan, Guray; Sökmensüer, Cenk; Kılınç, Kamer; Tuncer, Meral

doi:10.1016/j.ejphar.2009.03.038

Cited by 21 publications

(15 citation statements)

References 29 publications

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“…In parallel with these explained mechanisms, it has been shown that PDE-5 inhibitors could increase NO levels in both humans [51] and rats [24,25] with different tissue injuries. In one study, Soydan et al [25] showed that sildenafil pretreatment has a protective effect against ileal dysfunction and damage induced by intestinal I/R in the rat.…”

Section: Discussionmentioning

confidence: 92%

“…In one study, Soydan et al [25] showed that sildenafil pretreatment has a protective effect against ileal dysfunction and damage induced by intestinal I/R in the rat. The importance of this study is that the protective effects of sildenafil were attributed to its ability to induce NO production and the capability of NO to scavenge oxygen free radicals.…”

Section: Discussionmentioning

confidence: 98%

“…Several endogenous mechanisms exist to inhibit I/R lesions, and many drugs have also shown protective effects. The protection mechanisms against I/R-induced injury are multifactorial and still have not been clearly defined [25]. We planned this study because we hypothesized that giving a drug that decreases oxidative damage in addition to adnexal detorsion could have a protective effect over a long period, and our main goal was to determine the effect of TDF in the early phase of an ovarian I/R model.…”

Section: Discussionmentioning

confidence: 99%

“…The protective effect of PDE5 inhibitors on ischemia/ reperfusion (I/R) injury has been proven in various tissues, such as brain [21], kidney [22], myocardium [23], spinal cord [24], ileum [25], and testis [26]. However, there have been no studies that investigate the effect of these agents on ovarian I/R injury in the literature.…”

mentioning

confidence: 98%

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Protective effect of tadalafil on ischemia/reperfusion injury of rat ovary

Arıkan

Bakan

Kurutaş

et al. 2010

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

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Protective effect of tadalafil on ischemia/reperfusion injury of rat ovary

Arıkan

Bakan

Kurutaş

et al. 2010

Journal of Pediatric Surgery

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“…MPO activity is an indicator of neutrophil infiltration and increases in many inflammatory conditions including I/R injury [7]. In one study [29], increased MPO activity caused by intestinal I/R injury in rats was reversed to control levels with sildenafil pretreatment. Küçük et al [13] reported increased MDA and MPO levels in the renal I/R injury group compared with the control group.…”

Section: Discussionmentioning

confidence: 99%

Sildenafil Reduces Ischemia-Reperfusion Injury in Rat Ovary: Biochemical and Histopathological Evaluation

Çelik

Aksoy

Aksoy³

et al. 2014

Gynecol Obstet Invest

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Background/Aims: To evaluate the effects of sildenafil on antioxidant enzyme activities, lipid peroxidation and histopathological changes in ovarian tissue after ischemia-reperfusion (I/R) injury in a rat model. Methods: A total of 18 adult female Wistar albino rats weighing 200-250 g were studied as follows: (1) control group: sham operation, (2) I/R group: 3 h of reperfusion after 3 h of ischemia and (3) I/R + sildenafil group: 3 h of reperfusion after 3 h of ischemia; half an hour before reperfusion, sildenafil (1.4 mg·kg^-1) was given by oral gavage. At the end of the reperfusion periods, the ovarian tissues were removed for histopathological examination and to determine malondialdehyde (MDA) levels and glutathione peroxidase, myeloperoxidase (MPO) and superoxide dismutase (SOD) activities. Results: The I/R group had higher ovarian tissue MDA levels than the control group and the IR + sildenafil group (p = 0.016 and p = 0.044, respectively). MPO activity was lower in the IR + sildenafil group compared with the I/R group (p = 0.022). SOD activity was lower in the I/R group compared with the control group and the I/R + sildenafil group (p = 0.030 and p = 0.015, respectively). The I/R + sildenafil group had improved histological appearance which was not different to the control group (p > 0.05). Conclusion: The biochemical and histopathological results of this experimental study demonstrated that I/R injury in the ovary is ameliorated by sildenafil treatment.

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