2017
DOI: 10.3390/nano7080230
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The Effects of Silica Nanoparticles on Apoptosis and Autophagy of Glioblastoma Cell Lines

Abstract: Silica nanoparticles (SiNPs) are one of the most commonly used nanomaterials in various medical applications. However, possible mechanisms of the toxicity caused by SiNPs remain unclear. The study presented here provides novel information on molecular and cellular effects of SiNPs in glioblastoma LBC3 and LN-18 cells. It has been demonstrated that SiNPs of 7 nm, 5–15 nm and 10–20 nm induce time- and dose-dependent cytotoxicity in LBC3 and LN-18 cell lines. In contrast to glioblastoma cells, we observed only we… Show more

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Cited by 62 publications
(43 citation statements)
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“…The results demonstrate that exposure to ionizing radiation generates an excess of free radicals that contribute to the increase of fibrotic factors. In this context, it has been shown that oxidative stress induces the release of mitochondrial cytochrome c into the cytosol, where it can activate caspases and lead to apoptosis In addition, the apoptosis‐related genes ( p53 and TNF‐α ) are activated by oxidative stress . The increase of ALT, AST, ALP, and GGT, verify that irradiation has affected liver function.…”
Section: Discussionmentioning
confidence: 99%
“…The results demonstrate that exposure to ionizing radiation generates an excess of free radicals that contribute to the increase of fibrotic factors. In this context, it has been shown that oxidative stress induces the release of mitochondrial cytochrome c into the cytosol, where it can activate caspases and lead to apoptosis In addition, the apoptosis‐related genes ( p53 and TNF‐α ) are activated by oxidative stress . The increase of ALT, AST, ALP, and GGT, verify that irradiation has affected liver function.…”
Section: Discussionmentioning
confidence: 99%
“…It has been reported that Si-NPs can lead to apoptosis, mitophagy, autophagy, and consequently ROS accumulation in glioblastoma LBC3 cells representing a potential therapeutic agent for glioblastoma multiforme therapy [169]. …”
Section: Targeting Autophagy With Metal-based Nanoparticles As Therapmentioning
confidence: 99%
“…13 Preliminary reports on the application of SiNPs in cancer treatment are promising, with increased data suggesting antiproliferative effects in cancer cells compared to normal cells. 10,14 Following SiNP treatment, Lu et al demonstrated increased expression of p53 and caspase 3 and decreased expression of Bcl2 and procaspase 9 in human HEPG2 hepatoma cells, while none of these effects was observed in normal human L02 hepatocytes. 10 Likewise, our own research has revealed higher cytotoxicity in SiNPtreated glioblastoma LN18 and LBC3 cell lines, with only slight cytotoxic effects in normal skin fibroblasts.…”
Section: Introductionmentioning
confidence: 99%
“…10 Likewise, our own research has revealed higher cytotoxicity in SiNPtreated glioblastoma LN18 and LBC3 cell lines, with only slight cytotoxic effects in normal skin fibroblasts. 14 NP-dependent cytotoxicity may be of particular importance in cases of incurable cancers, such as glioblastoma multiforme, where new modalities of therapeutic strategies are highly desired. Unlike other cancers, brain tumors are particularly inaccessible to chemotherapeutics, due to the blood-brain barrier.…”
Section: Introductionmentioning
confidence: 99%