The Effects of Silver-Releasing Foam Dressings on Diabetic Foot Ulcer Healing

Wang, Yu-Chi; Lee, Hsiao-Chen; Chen, Chien‐Lin; Kuo, Ming-Chun; Ramachandran, Savitha; Chen, Rong‐Fu; Kuo, Yur-Ren

doi:10.3390/jcm10071495

Cited by 20 publications

(13 citation statements)

References 32 publications

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“…Similar results have been reported in a study that involved patients with burn wounds, where silver foam dressing relieved the patients of pain through infection control and rapid wound healing 36 . A recent study involving silver‐releasing foam dressings versus silver‐containing cream in managing outpatients with DFUs also found that silver‐dressing foam is effective, especially during the early stages of wound management 37 …”

Section: Results and Analysissupporting

confidence: 74%

“…36 A recent study involving silver-releasing foam dressings versus silvercontaining cream in managing outpatients with DFUs also found that silver-dressing foam is effective, especially during the early stages of wound management. 37 A combination of silver with magnesium in Ag-Mg-thermoplastic polyurethane (Ag-Mg-TPU) composite material has correspondingly been shown to increase both the amount and rate of silver ion released from the composite, and with an increased antimicrobial effect. 38 More recent advances in wound management technologies point to a brighter future for the healthcare sector and patients.…”

Section: Dressing Materialsmentioning

confidence: 99%

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Recent technological advances in the management of chronic wounds: A literature review

Ongarora

2022

Health Science Reports

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Background: Wound treatment comprises a substantial portion of the healthcare budgets in developed countries. Studies suggest that about 50% of patients admitted to hospitals have wounds, while 1%−2% of the general population in the developed world suffers from chronic wounds. Chronic wounds fail to repair themselves within the expected period of 30 days. Technologies have been developed to address challenges encountered during wound care with the aim of alleviating pain, promoting healing, or controlling wound infections.Objective: The objective of this study was to explore the technological improvements that have been made in this field over time. Methods:To gain insight into the future of wound management, a systematic review of literature on the subject was conducted in scientific databases (PubMed, Scopus, Web of Science, Medline, and Clinical Trials).Results and Discussion: Results indicate that wound dressings have evolved from the traditional cotton gauze to composite materials embedded with appropriate ingredients such as metal-based nanoparticles. Studies on biodegradable dressing materials are also underway to explore their applicability in dressing large and irregular wounds. On the other hand, conventional drugs and traditional formulations for the management of pain, inflammation, infections, and accelerating healing have been developed. However, more research needs to be carried out to address the issue of microbial resistance to drugs. Drugs for managing other ailments also need to be designed in such a way that they can augment wound healing. In addition, it has been demonstrated that a coordinated integration of conventional and traditional medicine can produce laudable results in chronic wound management. Conclusion:Accordingly, collaborative efforts and ingenuity of all players in the field can accelerate technological advances in the wound care market to the benefit of the patients.

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Section: Results and Analysissupporting

confidence: 74%

Section: Dressing Materialsmentioning

confidence: 99%

Recent technological advances in the management of chronic wounds: A literature review

Ongarora

2022

Health Science Reports

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“…These dressings with good water vapor permeability are utilized in the treatment of ulcers of the lower limbs, pressure ulcers (stage I–IV), skin transplants, and mild burns (stage I–II) [ 133 ]. The commercially available dressings based on polyurethane include Allevyn™, Askina Foam™, Tielle™, and Lyofoam™ [ 90 ]. However, unsuitability for dry wounds and frequent changes limits the effectiveness of such dressings.…”

Section: Wound Dressings and Recent Advancementsmentioning

confidence: 99%

In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings

Ahmad

2022

Pharmaceutics

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Chronic wound management represents a major challenge in the healthcare sector owing to its delayed wound-healing process progression and huge financial burden. In this regard, wound dressings provide an appropriate platform for facilitating wound healing for several decades. However, adherent traditional wound dressings do not provide effective wound healing for highly exudating chronic wounds and need the development of newer and innovative wound dressings to facilitate accelerated wound healing. In addition, these dressings need frequent changing, resulting in more pain and discomfort. In order to overcome these issues, a wide range of affordable and innovative modern wound dressings have been developed and explored recently to accelerate and improve the wound healing process. However, a comprehensive understanding of various in vitro and in vivo characterization methods being utilized for the evaluation of different modern wound dressings is lacking. In this context, an overview of modern dressings and their complete in vitro and in vivo characterization methods for wound healing assessment is provided in this review. Herein, various emerging modern wound dressings with advantages and challenges have also been reviewed. Furthermore, different in vitro wound healing assays and in vivo wound models being utilized for the evaluation of wound healing progression and wound healing rate using wound dressings are discussed in detail. Finally, a summary of modern wound dressings with challenges and the future outlook is highlighted.

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“…Some studies have reported that more complex skin dressings, including sponges, thin films, foams, hydrocolloids, silver dressings, and iodine dressings, are used as substitutes. In addition, a number of mixed dressings with antibacterial properties such as silver ion-containing foams and silver-containing activated carbon fibers are applied in the treatment of diabetic wounds [ 29 , 30 ]. However, these dressings still have some limitations.…”

Section: Wound Healingmentioning

confidence: 99%

Construction of Smart Biomaterials for Promoting Diabetic Wound Healing

Huang

Yuan

et al. 2023

Molecules

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Diabetes mellitus is a complicated metabolic disease that has become one of the fastest-growing health crises in modern society. Diabetic patients may suffer from various complications, and diabetic foot is one of them. It can lead to increased rates of lower-extremity amputation and mortality, even seriously threatening the life and health of patients. Because its healing process is affected by various factors, its management and treatment are very challenging. To address these problems, smart biomaterials have been developed to expedite diabetic wound closure and improve treatment outcomes. This review begins with a discussion of the basic mechanisms of wound recovery and the limitations of current dressings used for diabetic wound healing. Then, the categories and characteristics of the smart biomaterial scaffolds, which can be utilized as a delivery system for drugs with anti-inflammatory activity, bioactive agency, and antibacterial nanoparticles for diabetic wound treatment were described. In addition, it can act as a responsive system to the stimulus of the pH, reactive oxygen species, and glucose concentration from the wound microenvironment. These results show that smart biomaterials have an enormous perspective for the treatment of diabetic wounds in all stages of healing. Finally, the advantages of the construction of smart biomaterials are summarized, and possible new strategies for the clinical management of diabetic wounds are proposed.

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The Effects of Silver-Releasing Foam Dressings on Diabetic Foot Ulcer Healing

Cited by 20 publications

References 32 publications

Recent technological advances in the management of chronic wounds: A literature review

Recent technological advances in the management of chronic wounds: A literature review

In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings

Construction of Smart Biomaterials for Promoting Diabetic Wound Healing

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