The Effects of Single and Combined Pravastatin and Probucol Therapy in Hypercholesterolemia

Treatment - Drug Therapy

“…Combination therapies that have been reported in Japan to be effective for improving the serum lipid profile include: (1) statin and resin 88,90,91) , (2) statin and fibrate 92,93) , (3) statin and probucol 94) , (4) statin and nicotinate 95) , (5) probucol and nicotinate 96) , and (6) statin, probucol, and resin 97,98) . The combination of statin and resin is theoretically the most effective for reducing the LDL-C level, and the combination of statin and nicotinate not only reduces the cholesterol level but also increases the HDL-C level.…”

Treatment B) Drug Therapy

“…Combination therapies that have been proven to be effective in improving serum lipid profiles in Japanese populations include the following: (1) statins and resins 43,45,46) ; (2) statins and fibrates 47,48) ; (3) statins and probucol 49) ; (4) statins and nicotinic acid derivatives 50) ; (5) probucol and nicotinic acid derivatives 51) ; (6) statins, probucol and resins 52,53) ; and (7) statins and ezetimibe. The administration of statins in combination with ezetimibe or resins is theoretically the most effective means of decreasing the LDL-C level.…”