The effects of single intramuscular injection of vitamin D3 on minerals, hormone, and bone markers responses of multiparous Holstein cows fed a diet with negative dietary cation anion difference

Sadri, Shahab; Mohri, Mehrdad; Seifi, Hesam A

doi:10.1007/s00580-021-03270-9

Cited by 2 publications

(1 citation statement)

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“…In addition, a previous study has shown that vitamin D can increased insulin secretion by affects intracellular Ca concentration in pancreatic β cells and increased insulin secretion (Borges et al., 2011 ). In our companion paper, the amounts of serum total calcium were not significantly different between cows of trial groups, and the concentration of ionized calcium was significantly lower in the treatment group than control (Sadri et al., 2021 ). Thus, the effect of insulin on intracellular calcium was not probable.…”

Section: Discussionmentioning

confidence: 91%

Effects of vitamin D3 injection in close‐up period on insulin resistance and energy balance in transition dairy cows

Hassanabadi

Mohri

Seifi

2021

Veterinary Medicine & Sci

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Background Many studies in dairy cows are towards calcium homeostasis and there is a lack of knowledge about the effect of vitamin D in preventing insulin resistance and improving energy balance in the transition period of dairy cows. Methods The trial was conducted in a commercial dairy farm with about 1500 lactating cows in Tehran province, Iran. Twenty‐four Holstein cows had been randomly selected and divided into control and treatment groups. In the treatment group, 12 cows, received a single dose of 8,000,000 IU vitamin D3 intramuscularly and in the control group, 12 cows were injected placebo (distilled water) 2–8 days before the expected calving time. Blood samples were collected between 8 and 10 AM 2 h after feeding on 21 and 7 days before calving and 1,3,7,15 and 30 days after calving. 25(OH)vitamin D, insulin‐like growth factor 1 (IGF‐1), insulin, nonesterified fatty acid (NEFA), β‐hydroxybutyric acid (BHBA), albumin, total protein, glucose, urea, triglyceride, cholesterol and aspartate amino transferase (AST) were measured by commercially available kits. The insulin resistance index was calculated. Results Vitamin D3 injection significantly affected the amounts of 25(OH) vitamin D, urea, insulin and insulin resistance index (p ≤ 0.05). On the other hand, the amounts of glucose, NEFA, BHBA concentration and AST activity were higher in control group (p ≤ 0.05). Time had a significant effect on the amounts of most measured variables except IGF‐1 and insulin. There were no group and time interactions for measured variables. Conclusion It seems that injection of vitamin D3 in close up period influenced lipolysis potentially modifying energy metabolism and resulted in reducing insulin resistance.

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Section: Discussionmentioning

confidence: 91%