This research investigated the effects of creative drama on situational interest, career interest, and science-related attitudes of science majors and non-science majors. Also investigated were students' perception toward creative drama. 55 science majors and 28 non-science majors from five high schools in Malaysia voluntarily participated in this 5-day creative drama activity held in Taiwan. They completed pre-tests on "The Individual Interest Questionnaire" and "Test of Science-Related Attitudes". They designed, prepared, and presented their creative drama during the 5-day. A post-test was administered after the activity. Creative drama was found to have triggered the situational interest in science within both majors. The career interest and sciencerelated attitudes of science majors were found to have significant improvement; some students' perception toward science careers and science have changed after the activity. Some students commented that creative drama had developed their courage, social skills, teamwork, creativity, self-reflection, presentation skills, critical thinking, and problem-solving skills.