The effects of sodium butyrate and high-performance inulin supplementation on the promotion of gut bacterium Akkermansia muciniphila growth and alterations in miR-375 and KLF5 expression in type 2 diabetic patients: A randomized, double-blind, placebo-controlled trial

Roshanravan, Neda; Mahdavi, Reza; Jafarabadi, Mohammad Asghari; Ghavami, Abed; Saadat, Yalda Rahbar; Alamdari, Naimeh Mesri; Dastouri, Mohammadreza; Alipour, Shahriar; Ostadrahimi, Alireza

doi:10.1016/j.eujim.2017.12.011

Cited by 19 publications

(13 citation statements)

References 39 publications

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“…Increased production of short chain fatty acids in colon may control the expression of some genes and miRNAs which are involved in glucose homeostasis. 46 …”

Section: Discussionmentioning

confidence: 99%

Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail

Ghavami¹,

Roshanravan²,

Alipour³

et al. 2018

Adv Pharm Bull

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Purpose: The worldwide prevalence of metabolic disorders such as diabetes is increasing rapidly. Currently, the complications of diabetes are the major health concern. The aim of this study was to investigate the effect of high performance (HP) inulin supplementation on glucose homeostasis via KLF5 mRNA expression in adults with type 2 diabetes.Methods: In the present clinical trial conducted for a duration of 6 weeks, 46 volunteers diabetic patients referring to diabetes clinic in Tabriz, Iran, were randomly assigned into intervention (n= 23, consuming 10 gr/d HP inulin) and control groups (n= 23, consuming 10 gr/ d starch). We assessed glycemic and anthropometric indices, blood lipids and plasmatic level of miR-375 as well as KLF5 mRNA expression before and after the intervention.Results: Findings indicated that inulin supplementation significantly decreased fasting plasma glucose (FPG) in comparison to the placebo group (P<0.001). Also Intra-group and between group results showed that inulin supplementation resulted in significant decrease in KLF5 mRNA expression in peripheral blood mononuclear cells (PBMCs) (Fold change: 0.61± 0.11; P-value= 0.001) and significant increase in plasmatic level of miR-375 (Fold change: 3.75± 0.70; P-value=0.004).Conclusion: Considering the improvements of FPG level in diabetic patients, it seems that HP inulin supplementation may be beneficial in controlling diabetes via the expression of some genes. However, further studies are needed to achieve concise conclusions.

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“…Increased production of short chain fatty acids in colon may control the expression of some genes and miRNAs which are involved in glucose homeostasis. 46 …”

Section: Discussionmentioning

confidence: 99%

Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail

Ghavami¹,

Roshanravan²,

Alipour³

et al. 2018

Adv Pharm Bull

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“…In a clinical trial with T2D patients, the relative abundance of A. muciniphila , a mucin-associated bacterium with anti-inflammatory properties, increased after inulin and sodium butyrate prebiotic supplementation [156,157,158].…”

Section: Gut Microbiota Changes In Particular Pathologiesmentioning

confidence: 99%

Microbial Population Changes and Their Relationship with Human Health and Disease

et al. 2019

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Specific microbial profiles and changes in intestinal microbiota have been widely demonstrated to be associated with the pathogenesis of a number of extra-intestinal (obesity and metabolic syndrome) and intestinal (inflammatory bowel disease) diseases as well as other metabolic disorders, such as non-alcoholic fatty liver disease and type 2 diabetes. Thus, maintaining a healthy gut ecosystem could aid in avoiding the early onset and development of these diseases. Furthermore, it is mandatory to evaluate the alterations in the microbiota associated with pathophysiological conditions and how to counteract them to restore intestinal homeostasis. This review highlights and critically discusses recent literature focused on identifying changes in and developing gut microbiota-targeted interventions (probiotics, prebiotics, diet, and fecal microbiota transplantation, among others) for the above-mentioned pathologies. We also discuss future directions and promising approaches to counteract unhealthy alterations in the gut microbiota. Altogether, we conclude that research in this field is currently in its infancy, which may be due to the large number of factors that can elicit such alterations, the variety of related pathologies, and the heterogeneity of the population involved. Further research on the effects of probiotics, prebiotics, or fecal transplantations on the composition of the human gut microbiome is necessary.

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“…Several clinical trials have evaluated the protective effects of natural products on T2DM via gut microbiota [120,121]. A double-blind, randomized, controlled clinical trial (RCT) involving 60 patients with T2DM found that the supplementation of 10 g/day inulin powder promoted the gut health by increasing the proportion of Akkermansia muciniphila [120].…”

Section: The Relationships Among Natural Products Gut Microbiotamentioning

confidence: 99%

Targeting Gut Microbiota for the Prevention and Management of Diabetes Mellitus by Dietary Natural Products

Gan

et al. 2019

Foods

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Diabetes mellitus is one of the biggest public health concerns worldwide, which includes type 1 diabetes mellitus, type 2 diabetes mellitus, gestational diabetes mellitus, and other rare forms of diabetes mellitus. Accumulating evidence has revealed that intestinal microbiota is closely associated with the initiation and progression of diabetes mellitus. In addition, various dietary natural products and their bioactive components have exhibited anti-diabetic activity by modulating intestinal microbiota. This review addresses the relationship between gut microbiota and diabetes mellitus, and discusses the effects of natural products on diabetes mellitus and its complications by modulating gut microbiota, with special attention paid to the mechanisms of action. It is hoped that this review paper can be helpful for better understanding of the relationships among natural products, gut microbiota, and diabetes mellitus.

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The effects of sodium butyrate and high-performance inulin supplementation on the promotion of gut bacterium Akkermansia muciniphila growth and alterations in miR-375 and KLF5 expression in type 2 diabetic patients: A randomized, double-blind, placebo-controlled trial

Cited by 19 publications

References 39 publications

Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail

Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail

Microbial Population Changes and Their Relationship with Human Health and Disease

Targeting Gut Microbiota for the Prevention and Management of Diabetes Mellitus by Dietary Natural Products

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