The Effects of Somatostatin on Immune Cells, Functions and Diseases

Talme, Toomas; Sundqvist, Kristina

doi:10.1007/978-3-7091-0888-8_7

Cited by 2 publications

(2 citation statements)

References 148 publications

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“…62 Additionally, the agonist for SSTR2, somatostatin, has been found to impair immune function in humans. 63 Another promising host reporter is the sodium iodide symporter (NIS), which has been used in a number of celltracking applications due to its lack of expression in most tissues and availability of small anionic radiotracers for PET and single photon emission computed tomography imaging. 64,65 NIS has been used successfully in murine models for tracking CAR-T therapy, showing good contrast and signal-to-background ratio.…”

Section: Adoptive Cell Transfermentioning

confidence: 99%

“…However, SSTR2 is endogenous in multiple tissue types and certain immune cell lineages, which limits imaging specificity 62 . Additionally, the agonist for SSTR2, somatostatin, has been found to impair immune function in humans 63 . Another promising host reporter is the sodium iodide symporter (NIS), which has been used in a number of cell-tracking applications due to its lack of expression in most tissues and availability of small anionic radiotracers for PET and single photon emission computed tomography imaging 64,65 .…”

Section: Adoptive Cell Transfermentioning

confidence: 99%

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PET Imaging for Monitoring Cellular and Immunotherapy of Cancer

Larimer

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Cancer immunotherapy, including checkpoint blockade and cellular therapy, has become a cornerstone in cancer treatment. However, understanding the factors driving patient response or resistance to these therapies remains challenging. The dynamic interplay between the immune system and tumors requires new approaches for characterization. Biopsies and blood tests provide valuable information, but their limitations have led to increased interest in positron emission tomography (PET)/computed tomography imaging to complement these strategies. The noninvasive nature of PET imaging makes it ideal for monitoring the dynamic tumor immune microenvironment. This review discusses various PET imaging approaches, including immune cell lineage markers, immune functional markers, immune cell metabolism, direct cell labeling, and reporter genes, highlighting their potential in targeted immunotherapies and cell-based approaches. Although PET imaging has limitations, its integration into diagnostic strategies holds promise for improving patient outcomes and accelerating drug development in cancer immunotherapy.

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Section: Adoptive Cell Transfermentioning

confidence: 99%

Section: Adoptive Cell Transfermentioning

confidence: 99%

PET Imaging for Monitoring Cellular and Immunotherapy of Cancer

Larimer

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Traditional Chinese Medicine Formulas for Irritable Bowel Syndrome: From Ancient Wisdoms to Scientific Understandings

et al. 2015

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Traditional Chinese Medicine (TCM) serves as the most common alternative therapeutic approach for Western medicine and benefits IBS patients globally. Due to the lack of scientific evidence in the past, TCM formulas were not internationally well recognized as promising IBS remedies. In this review, firstly, we present the etiology and therapy of IBS in terms of traditional Chinese medical theory. Secondly, we summarize the clinical randomized controlled trials (RCTs) of TCM formulas for IBS patients that are available in the literature (from 1998 to September 2013), in which 14 RCTs conducted of high quality were discussed in detail. Of the 14 selected trials, 12 of those concluded that TCM formulas provided superior improvement in the global symptoms of IBS patients over the placebo or conventional medicines. As well, all 14 RCTs suggested that TCM formulas have good safety and tolerability. Last but not least, we explore the pharmacological mechanisms of the anti-IBS TCM formulas available in the literature (from 1994 to September, 2013). Collectively, in combating IBS symptoms, most TCM formulas exert multi-targeting actions including the regulation of neurotransmitters and hormones in the enteric nervous system (ENS), modulation of smooth muscle motility in the gastrointestinal (GI) tract, modulation of the hypothalamic-pituitary-adrenal (HPA) axis, attenuation of intestinal inflammation and restoration of intestinal flora, etc. In conclusion, TCM formulas appear to be promising for IBS treatment. This review provides a useful reference for the public in furthering a better understanding and acceptance of TCM formulas as IBS remedies.

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The Effects of Somatostatin on Immune Cells, Functions and Diseases

Cited by 2 publications

References 148 publications

PET Imaging for Monitoring Cellular and Immunotherapy of Cancer

PET Imaging for Monitoring Cellular and Immunotherapy of Cancer

Traditional Chinese Medicine Formulas for Irritable Bowel Syndrome: From Ancient Wisdoms to Scientific Understandings

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