The effects of some drugs on the rigidity of the cat due to ischaemic or intercollicular decerebration

Maxwell, D. R.; Read, M.A.

doi:10.1016/0028-3908(72)90043-3

Cited by 15 publications

(5 citation statements)

References 16 publications

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“…(RANDALL et aI., 1965 a). In comparing diazepam in the two types of rigidity (y and IX), MAXWELL and READ (1972) concluded that diazepam was more effective in reducing rigidity in the intercollicular, decerebrate cats than in the anemic, decerebrate cats.…”

Section: Ex-rigiditymentioning

confidence: 98%

See 1 more Smart Citation

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

Haefely¹,

Pieri²,

Polc³

et al. 1981

Handbook of Experimental Pharmacology

114

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Section: Ex-rigiditymentioning

confidence: 98%

“…The rigidity obtained by the anemic method in the cat (for references see MAXWELL and READ, 1972) is thought to be due primarily to the overactivity of the IX-motoneuron system. SCHALLEK et ai.…”

Section: Ex-rigiditymentioning

confidence: 99%

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

Haefely¹,

Pieri²,

Polc³

et al. 1981

Handbook of Experimental Pharmacology

114

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“…Furthermore, dimethothiazine, chlorpromazine (Maxwell & Read, 1972) and M & B 18,706 (Maxwell et al, 1974) have less than one-tenth the potency in reducing the rigidity of cats decerebrated by the ischaemic method than they do in reducing intercollicular decerebrate rigidity. The rigidity of cats decerebrated by the ischaemic method is not due to enhanced activity of fusimotor neurones (Granit, 1970).…”

Section: Discussionmentioning

confidence: 99%

“…The method used to measure the degree of decerebrate rigidity and its reduction by drugs was that described by Maxwell & Read (1972) and Maxwell, Read & Sumpter (1974). The electromyogram (EMG) of the quadriceps muscle was recorded and integrated whilst that muscle was slowly stretched by the weight of the lower leg.…”

Section: Antagonism Of Noradrenaline-induced Pressor Responses In Thementioning

confidence: 99%

A Comparison of the Actions of Some Drugs on Decerebrate Rigidity, Muscle Spindle Activity and Α‐adrenoceptors

Maxwell

Sumpter

1974

British J Pharmacology

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The relative potencies of methotrimeprazine, (+)‐methotrimeprazine, (±)‐10‐(3‐dimethylamino‐2‐methylpropyl)‐2‐valeroyl phenothiazine hydrochloride (M & B 18,706) and (+)‐M & B 18,706 in reducing the pressor action of noradrenaline in the spinal cat, reducing intercollicular decerebrate rigidity, and muscle spindle afferent activity have been studied. Methotrimeprazine was eight times as potent as (+)‐methotrimeprazine in reducing the pressor action of noradrenaline and six times as potent in reducing decerebrate rigidity. M & B 18,706 was also eight times as potent as (+)‐M & B 18,706 in reducing the pressor action of noradrenaline and six times as potent in reducing decerebrate rigidity. For the above compounds and chlorpromazine there was a significant correlation between the effective doses for the inhibition of the pressor action of noradrenaline and for the reduction of decerebrate rigidity. The doses which reduced decerebrate rigidity were similar to those that reduced muscle spindle afferent discharge. It is likely that these drugs reduce decerebrate rigidity by inhibiting fusimotor activity. Desipramine increased decerebrate rigidity and increased spindle afferent discharge. It is thought that the phenothiazine derivatives studied reduce decerebrate rigidity and spindle afferent discharge by inhibiting receptors for noradrenaline in the central nervous system.

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“…1974a). Animals with decerebrate rigidity have proved useful for the study of the mechanisms of action of the centrally acting muscle relaxants and some CNS depressants (Maxwell & Read, 1972;Sontag & Wand, 1973;Maxwell & Sumpter, 1974;Fukuda et al, 1974a,b;Anderson & Raines, 1976;Wand et al, 1977;Ochiai & Ishida, 1982;Goto et al, 1982;1983;Raines et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

A new class of potent centrally acting muscle relaxants: pharmacology of oxazolidinones in rat decerebrate rigidity

Masaki

Shinozaki

1986

British J Pharmacology

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1 The severity of anaemic decerebrate rigidity was quantitatively determined by measuring the frequency of electromyographic potentials in the rat. 2 Some oxazolidinones markedly reduced the severity ofthis decerebrate rigidity in a dose-dependent manner,one (MLV-6976) being the most potent. In addition to the oxazolidinones, an aminoalcohol derivative, (1RS,2SR)-5-methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol (MLV-5860) also reduced the rat decerebrate rigidity. 3 In the oxazolidinone series, the optical isomers with absolute configuration (S) at the 4-position were more potent than the corresponding (4R)-isomers, while there was no significant difference in their LD50 values. 4 Normal rats and mice receiving MLV-6976 at doses which reduced decerebrate rigidity showed no behavioural changes, impairment of motor coordination only appearing at extremely high doses. MLV-6976 and its derivatives did not affect spinal reflex potentials in cats. 5 MLV-6976 reduced the severity of harmaline-induced tremor in mice in a dose-dependent manner, but slightly augmented tremorine-induced tremor. 6 The frequency of the spike discharges induced by iontophoretically applied glutamate was reduced by MLV-6976 in a dose-dependent manner in rat cortical neurones. 7 The amplitude of miniature endplate potentials of the rat diaphragm was decreased by MLV-6976 only at concentrations greater than 0.1 mM. 8 It is concluded that MLV-6976 acts on the brainstem or/and higher levels of the brain rather than on the spinal cord or the peripheral nervous system to reduce the excessive activities of the nervous system.

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The effects of some drugs on the rigidity of the cat due to ischaemic or intercollicular decerebration

Cited by 15 publications

References 16 publications

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

A Comparison of the Actions of Some Drugs on Decerebrate Rigidity, Muscle Spindle Activity and Α‐adrenoceptors

A new class of potent centrally acting muscle relaxants: pharmacology of oxazolidinones in rat decerebrate rigidity

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