The effects of spirulina on glycemic control and serum lipoproteins in patients with metabolic syndrome and related disorders: A systematic review and meta‐analysis of randomized controlled trials

Hamedifard, Zahra; Milajerdi, Alireza; Reiner, Željko; Taghizadeh, Mohsen; Kolahdooz, Fariba; Asemi, Zatollah

doi:10.1002/ptr.6441

Cited by 35 publications

(23 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thirteen of these studies were excluded because they included an abstract ( N = 5) or a protocol ( N = 1) only, were not published in English ( N = 1), had inappropriate exposures ( N = 2) or outcomes ( N = 1), or did not provide updated data ( N = 2). As a result, 50 systematic reviews and meta‐analyses were included in the final analysis (Figure 1; Amir Shaghaghi et al, 2013; Askari et al, 2019; Azhdari et al, 2019; Chen et al, 2020; Fatahi et al, 2019; Ghaedi et al, 2019; Ghaedi et al, 2020; Glisic et al, 2018; Gui et al, 2016; Hadi et al, 2018, 2020; Hadi, Pourmasoumi, Mohammadi, et al, 2019; Hadi, Pourmasoumi, Najafgholizadeh, et al, 2019; Hallajzadeh et al, 2020; Hamedifard et al, 2019; Han et al, 2019; Hasani et al, 2019; Hemati et al, 2020; Hernández‐García et al, 2019; Heshmat‐Ghahdarijani et al, 2020; Karimian et al, 2019; Khorshidi et al, 2020; Li et al, 2014, 2015, 2020; Maierean et al, 2017; Mansour‐Ghanaei et al, 2018; Mohammadi, Hadi, et al, 2019; Mohammadi, Ramezani‐Jolfaie, et al, 2019; Ostadmohammadi et al, 2019; Pourmasoumi et al, 2018, 2020; Rahmani et al, 2019; Rahmani et al, 2020; Ricci et al, 2010; Ried, 2016; Rocha et al, 2019; Sahebkar, 2014; Sahebkar, Simental‐Mendía, et al, 2016; Sahebkar, Soranna, et al, 2016; Salehi‐Sahlabadi et al, 2020; Serban et al, 2015; Shekarchizadeh‐Esfahani et al, 2020; Taku et al, 2010; Ursoniu et al, 2018; Zhang et al, 2020; Zhang, Yuan, et al, 2016; Zhang, Liu, et al, 2016; Zhu et al, 2017; Ziaei et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

“…Among them, Aloe vera , fenugreek, and spirulina were shown to statistically improve lipid profiles and combat hyperglycemia. The mechanisms underlying the regulation of glucose and lipid metabolism were proposed due to the rich contents of polysaccharides and phytosterols in Aloe vera (Zhang, Liu, et al, 2016), the large amounts of 4‐hydroxyisoleucine amino acid, polyphenols, saponin, and gel‐like dissolvable fiber in fenugreek (Heshmat‐Ghahdarijani et al, 2020), and the large amount of fiber, polypeptides, and C‐phycocyanin protein in spirulina (Hamedifard et al, 2019). However, the aforementioned mechanisms were also only based on experimental studies.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Phytonutrient supplements and metabolic biomarkers of cardiovascular disease: An umbrella review of meta‐analyses of clinical trials

Hoang

Kim

2021

Phytotherapy Research

View full text Add to dashboard Cite

Phytonutrients exert several pharmacological effects on humans. In this study, we performed an umbrella review of the association of phytonutrient supplements (PNSs) with biomarkers of cardiovascular disease. Relevant published systematic reviews and meta‐analyses of clinical trials were identified by searching PubMed, Embase, and Cochrane Library until July 4, 2020. Weighted mean differences (WMDs) and 95% confidence intervals (CIs) for summarized effects and I2 statistics of heterogeneity were extracted from individual studies or reanalyzed using a random‐effects model. Of the 50 included studies, pooled effects of PNSs on blood pressure, lipid profiles, and glycemic control were reported in 16, 25, and 14 articles, respectively. The findings appeared to be highly heterogeneous among individual trials of included systematic reviews and meta‐analyses. Ginger (WMD = −6.36 mmHg, 95% CI = −11.27, −1.46) and Hibiscus sabdariffa (WMD = −7.58 mmHg, 95% CI = −9.69, −5.46) were associated with lowered systolic blood pressure, whereas Aloe vera, Nigella sativa, and spirulina were associated with beneficial effects on both lipid profiles and glycemic control. In summary, this umbrella review has provided up‐to‐date evidence for the effect of PNSs on biomarkers related to hypertension, dyslipidemia, and diabetes. The results must be interpreted with caution due to potential heterogeneity.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Phytonutrient supplements and metabolic biomarkers of cardiovascular disease: An umbrella review of meta‐analyses of clinical trials

Hoang

Kim

2021

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Interestingly, the weight loss was not dose-dependent and was higher in patients with obesity rather than in those with overweight [201]. Many beneficial effects, both on glucose and lipid metabolism and oxidant status, have been described in human studies [200][201][202]. However, no data about the potential role of spirulina on energy expenditure are available; therefore, at present, no compelling evidence on this topic is available.…”

Section: Spirulinamentioning

confidence: 98%

A Critical Review on the Role of Food and Nutrition in the Energy Balance

Fadda

Fedele

et al. 2020

Nutrients

View full text Add to dashboard Cite

The mass media has increasingly frequently suggested to the general population that specific foods or nutritional schemes are able to affect both human metabolism and energy expenditure, thus facilitating weight loss. This critical review is aimed at assessing available evidence on the roles of nutrients, food and dietary regimens in energy intake and energy expenditure. We queried the National Library of Medicine, the Cochrane Library, Excerpta Medica dataBASEand the Cumulative Index to Nursing and Allied Health Literature database, and a search strategy was performed by using database-specific subject headings and keywords. We found that available scientific evidence on these topics is scarce, and that the limited number of available studies often have poor methodological quality. Only a few foods show beneficial effects on metabolism and energy expenditure, as the human energy balance is complex and multifactorial. Finally, microbiota may interfere with the intake, use and expenditure of energy in the human body. Conclusive evidence is still lacking, and, at present, it is not possible to identify a food or a diet with a significant impact on human energy expenditure.

show abstract

“…In contrast, several studies revealed that 2-4.5 g/day spirulina supplementation significantly reduced the SBP or DBP. [48][49][50][51][52] However, Huang et al, 47 in their meta-analysis, observed that spirulina administration has a beneficial effect on DBP improvement, but not SBP.…”

Section: Ta B L Ementioning

confidence: 99%

“…Indeed, the extant literature posits that spirulina contains phycocyanin and peptides with antihypertensive properties which may be able to decrease the SBP or DBP via increases nitric oxide synthase, inhibition of angiotensin I-converting enzymes and consequently inhibiting renin-angiotensin-aldosterone system. [48][49][50][51][52] However, the effective spirulina dosage and its' mechanism of action on blood pressure are still controversial, and therefore, more clinical trials with a longer length of intervention and suitably powered sample sizes are essential.…”

Section: Ta B L Ementioning

confidence: 99%

The effects of spirulina (Arthrospira platensis) supplementation on anthropometric indices, blood pressure, sleep quality, mental health, fatigue status and quality of life in patients with ulcerative colitis: A randomised, double‐blinded, placebo‐controlled trial

et al. 2021

View full text Add to dashboard Cite

Background: An emerging body of evidence has highlighted the protective role of spirulina in human health. Thus, we conducted a randomised controlled trial to discern the effects of spirulina supplementation on anthropometric indices, blood pressure, sleep quality, mood, fatigue status and quality of life among ulcerative colitis patients.Methods: Eighty participants with ulcerative colitis were randomly allocated to receive, either, 1 g/day (two 500 mg capsules) spirulina (n = 40) or placebo (n = 40), in a clinical trial for eight weeks. Dietary intake, physical activity, sleep quality, mental health, fatigue status and quality of life were assessed for each participant at baseline and trial cessation. Anthropometric indices and blood pressure were also assessed.Results: Seventy-three participants completed the intervention. Our results revealed that spirulina supplementation significantly reduced sleep disturbances (P = .03), while no significant changes occurred in the sleep quality score or other sleep parameters, vs the placebo group (P > .05). Furthermore, a significant reduction in stress score (P = .04) and increase in quality of life (P = .03) was detected; but not anxiety, depression or fatigue scores (P > .05). Additionally, anthropometric indices and blood pressure did not significantly change (P > .05). Conclusion:An improved quality of life was observed among ulcerative colitis patients following spirulina supplementation, which could be attributed to improved sleep disturbance and stress status. Further clinical studies, with longer duration interventions and suitably powered sample sizes, are necessary to elucidate the veracity of our findings. How to cite this article: Moradi S, Zobeiri M, Feizi A, Clark CCT, Entezari MH. The effects of spirulina (Arthrospira platensis) supplementation on anthropometric indices, blood pressure, sleep quality, mental health, fatigue status and quality of life in patients with ulcerative colitis: a randomised, double-blinded, placebo-controlled trial. Int J Clin Pract.

show abstract

The effects of spirulina on glycemic control and serum lipoproteins in patients with metabolic syndrome and related disorders: A systematic review and meta‐analysis of randomized controlled trials

Cited by 35 publications

References 39 publications

Phytonutrient supplements and metabolic biomarkers of cardiovascular disease: An umbrella review of meta‐analyses of clinical trials

Phytonutrient supplements and metabolic biomarkers of cardiovascular disease: An umbrella review of meta‐analyses of clinical trials

A Critical Review on the Role of Food and Nutrition in the Energy Balance

The effects of spirulina (Arthrospira platensis) supplementation on anthropometric indices, blood pressure, sleep quality, mental health, fatigue status and quality of life in patients with ulcerative colitis: A randomised, double‐blinded, placebo‐controlled trial

Contact Info

Product

Resources

About