The Effects of Stereotactic Electrical Stimulation in the Depth of the Brain

Schaltenbrand, Georg

doi:10.1093/brain/88.4.835

Cited by 81 publications

(25 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Autonomic effects have been described during electric stimulation or lesion experiments in animals [1,10], subthalamic surgery for extrapyramidal pathology in man [8,25,34,35,37] or during stimulation of a more medial area between the postero-lateral hypothalamus and the STN [33]. The localization and type of those effects, essentially tachycardia and mydriasis homolateral to the stimulation, are consistent with those observed in our series.…”

Section: Localization Of Autonomic Effectssupporting

confidence: 88%

Motor and non motor effects during intraoperative subthalamic stimulation for Parkinson?s disease

et al. 2005

View full text Add to dashboard Cite

Spatial distribution of the clinical effects induced by deep brain stimulation during the intraoperative investigation of the subthalamic nucleus (STN) for Parkinson's disease (PD) was analysed in 17 patients under local anesthesia. The stimulation parameters were 130 hertz, 100 micros, and voltage ranged from 0.05 to 5 volts. Optimal motor response was assessed as the total and lasting disappearance of wrist rigidity on the side opposite to stimulation. Among the adverse effects induced by stimulation, special attention was given to frequently observed autonomic effects (AE). Full motor response was achieved in 49.2% of the 301 points evaluated,with a mean voltage (MV) of 0.94 volts; paresthesiae occurred in 6.6% (MV: 2 volts), dystonia in 10.6% (MV: 3.4 volts), autonomic effects in 19.6% (MV: 3.1 volts) and oculomotor effects in 31.6% (MV: 3 volts). The motor target was located in the posterodorsal part of the nucleus and the optimal point for motor response was close to the superior limit of the nucleus. Whereas other adverse effects occurred relatively far from the motor target, AE occurred with statistic significance near this point. Their neural substrates, such as limbic system and their relationship with postoperative behavioral disorders, are discussed.

show abstract

Section: Localization Of Autonomic Effectssupporting

confidence: 88%

Motor and non motor effects during intraoperative subthalamic stimulation for Parkinson?s disease

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Electrical stimulation of brain structures has been used in research since the early 1900s and was a method of determining function localization prior to neural surgery (Schaltenbrand, 1965). Schaltenbrand described the effects of exploratory electrical stimulation of subcortical nuclei on behaviors in individuals with parkinsonian syndrome.…”

Section: Introductionmentioning

confidence: 99%

The role of subcortical structures in recited speech: Studies in Parkinson's disease

Bridges

Sidtis

2013

Journal of Neurolinguistics

View full text Add to dashboard Cite

The role of subcortical structures in language function is complex and dependent on language task, with studies increasingly showing subcortical involvement for the production of formulaic language, including recited speech. Individuals with Parkinson's disease (PD), with (n = 6) and without (n = 7) surgical treatment, deep brain stimulation (DBS), were compared to healthy adults (n = 14) to determine whether individuals with subcortical dysfunction produce more errors during a recitation speech task. Participants were asked to recite poems, prayers, and rhymes familiar to them in order to determine the effects of subcortical disease on recited speech ability. When compared with healthy controls, the DBS-OFF group produced significantly more error words, suggesting that deficits in recitation arise with severe states of subcortical dysfunction. Individuals with DBS in the ON or OFF conditions did not differ significantly during the recited speech task. Results support a model of language where large units of overlearned language are at least partially modulated by subcortical structures.

show abstract

“…Further evidence of a subcortical role in formulaic expression production comes from stimulation studies and observations of increased incidence. During stereotaxic surgery, formulaic expressions are sometimes elicited when subcortical structures are stimulated (Schaltenbrand, 1965; Petrovici, 1980). Hyperactivation of one type of formulaic expression, cursing, is seen in many cases of Tourette’s syndrome, a disease which is believed to arise from subcortical dysfunction (Van Lancker and Cummings, 1999).…”

Section: Introduction and Rationalementioning

confidence: 99%

Effects of neurological damage on production of formulaic language

Sidtis

Canterucci

Katsnelson

2009

Clinical Linguistics & Phonetics

View full text Add to dashboard Cite

Early studies reported preserved formulaic language in left hemisphere damaged subjects and reduced incidence of formulaic expressions in the conversational speech of stroke patients with right hemispheric damage. Clinical observations suggest a possible role also of subcortical nuclei. This study examined formulaic language in the spontaneous speech of stroke patients with left, right, or subcortical damage. Four subjects were interviewed and their speech samples compared to normal speakers. Raters classified formulaic expressions as speech formulae, fillers, sentence stems, and proper nouns. Results demonstrated that brain damage affected novel and formulaic language competence differently, with a significantly smaller proportion of formulaic expressions in subjects with right or subcortical damage compared to left hemisphere damaged or healthy speakers. These findings converge with previous studies that support the proposal of a right hemisphere/subcortical circuit in the management of formulaic expressions, based on a dual-process model of language incorporating novel and formulaic language use.

show abstract

The Effects of Stereotactic Electrical Stimulation in the Depth of the Brain

Cited by 81 publications

References 0 publications

Motor and non motor effects during intraoperative subthalamic stimulation for Parkinson?s disease

Motor and non motor effects during intraoperative subthalamic stimulation for Parkinson?s disease

The role of subcortical structures in recited speech: Studies in Parkinson's disease

Effects of neurological damage on production of formulaic language

Contact Info

Product

Resources

About