The effects of sumatriptan on pituitary secretion in man

Franceschini, R.; Cataldi, A.; Garibaldi, A; Cianciosi, P; Scordamaglia, A; Barreca, T; Rolandi, E

doi:10.1016/0028-3908(94)90014-0

Cited by 31 publications

(22 citation statements)

References 24 publications

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“…GH response to sumatriptan in healthy individuals may be mediated by 5-HT1d receptors located in the median eminence of the hypothalamus which facilitate the release of growth hormone releasing hormone (GHRH) which in turn stimulates GH release (Franceschini et al 1994;Yatham et al 1997). Stimulation of 5HT 1d receptors may also inhibit the release of somatosta- tin thereby decreasing inhibitory tone on GH release (Mota et al 1995).…”

Section: Discussionmentioning

confidence: 99%

“…The 5HT 1d receptor has both alpha and beta subtypes, however sumatriptan binds nonspecifically to both subtypes (Bard et al 1996). Sumatriptan has been shown to increase growth hormone release in normal controls (Franceschini et al 1994) via increased growth hormone releasing hormone (GHRH) which stimulates GH release, and inhibition of somatostatin which inhibits GH release (Yatham et al 1997;Mota et al 1995). Anecdotal case reports have suggested that sumatriptan improved symptoms of autism, as well as migraine headaches when taken by patients who suffer from both disorders.…”

Section: Autism Is Heterogeneous With Respect To Clinical Symptoms Anmentioning

confidence: 99%

“…These values were compared to autism patients by t-test and were found to differ at the p Յ .10 level (Novotny et al 1999 in press). This is consistent with hypersensitivity of the 5HT 1d receptor in autism.GH response to sumatriptan in healthy individuals may be mediated by 5-HT1d receptors located in the median eminence of the hypothalamus which facilitate the release of growth hormone releasing hormone (GHRH) which in turn stimulates GH release (Franceschini et al 1994;Yatham et al 1997). Stimulation of 5HT 1d receptors may also inhibit the release of somatosta- …”

mentioning

confidence: 99%

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The Relationship between Repetitive Behaviors and Growth Hormone Response to Sumatriptan Challenge in Adult Autistic Disorder

Hollander

2000

Neuropsychopharmacology

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Autism is heterogeneous with respect to clinical symptoms and etiology. To sort out this heterogeneity in autismAutism is heterogeneous with respect to clinical symptoms and etiology. To sort out this heterogeneity in autism, one might determine whether specific neurobiological markers vary in parallel to key clinical symptoms. Autism is characterized by three unique behavioral dimensions: social impairment, communication difficulties and rigid, restricted interests, and repetitive behaviors. One recent study explored the relationship between repetitive behaviors in autism and D8/17, a B-lymphocyte antigen marker expressed at increased levels in patients with rheumatic fever, as well as in patients with neuropsychiatric disorders characterized by repetitive behaviors such as Sydenham's chorea, Tourette's syndrome and obsessivecompulsive disorder. Of interest, obsessive compulsive disorder (OCD) occurs with increased frequency in first degree relatives of autistic patients and is associated with the broader phenotype of autism (Bolton et al. 1998). D8/17 expression was found to be significantly positively correlated with the severity of repetitive behaviors as measured by the Yale-Brown Obsessive Compulsive Scale-compulsivity subscale in childhood and adolescent autism . We have hypothesized that repetitive behaviors in autism may also be related to serotonergic (5-HT) dysfunction (Hollander et al. 1998).Pharmacological treatment studies support a role of 5-HT in autistic disorders. (Mehlinger et al. 1990) and sertraline (Steingard et al. 1997) have documented efficacy in treating both global autistic symptoms as well as symptoms of repetitive behaviors and restricted interests in up to 60% of patients treated.Several biological studies have also suggested 5-HT dysregulation in autistic patients, however the findings have not been uniform, but rather replicated in subgroups of patients. For example, contradictory results in linkage disequilibrium analyses of two common alleles (long and short) of the 5HT transporter (5HTT) gene have been reported. While there was linkage between the short allele and a narrowly defined group of autistic probands (Cook et al. 1997), an association between the long allele and a more broadly defined group of autistic probands has also been reported (Klauck et al. 1997).Pharmacological challenge studies with 5-hydroxytryptophan and fenfluramine have demonstrated reduced prolactin response in some patients with autism (Hoshino et al. 1984;McBride et al. 1989), however age, gender, and racial/ethnic factors may account for some of the heterogeneity. Depletion of the 5-HT precursor, tryptophan, induced a worsening of autistic symptoms in some, but not all, patients (McDougle et al. 1996a). There is evidence for increased whole blood serotonin not only in patients with autism (Hoshino et al. 1984;Anderson et al. 1987), but also in their first degree relatives (Piven et al. 1991;Cook et al. 1994;Leboyer et al. 1999). Of interest, parents of autistic patients with increased whole blood ser...

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Section: Discussionmentioning

confidence: 99%

Section: Autism Is Heterogeneous With Respect To Clinical Symptoms Anmentioning

confidence: 99%

mentioning

confidence: 99%

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The Relationship between Repetitive Behaviors and Growth Hormone Response to Sumatriptan Challenge in Adult Autistic Disorder

Hollander

2000

Neuropsychopharmacology

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“…This compound has previously been shown to increase basal GH levels in humans without affecting cortisol secretion [32]or the secretion of any other pituitary hormone [20, 22]. …”

Section: Discussionmentioning

confidence: 99%

“…We specifically study the 5-HT 1D subtypes because at that moment this receptor was the only one that was clearly implicated in the control of GH secretion in several species, including humans [19, 20, 21, 22]. …”

Section: Introductionmentioning

confidence: 99%

Influence of Different Serotonin Receptor Subtypes On Growth Hormone Secretion

Valverde

Peñalva²,

Diéguez

2000

Neuroendocrinology

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The role of serotonin (5-HT) in the regulation of growth hormone (GH) secretion remains unclear due to the existence of many different receptors that mediate the 5-HT actions, and the lack of suitable specific agonist and antagonist drugs. In the present work we have taken advantage of the recent development of new selective 5-HT drugs in order to clarify the role played by different 5-HT receptor types and subtypes on GH secretion. The experiments were carried out on beagle dogs. GH-releasing hormone (GHRH) increased basal canine GH (cGH) levels from 0.8 ± 0.2 to 8.8 ± 1.7 µg/l at 15 min. Administration of 5-HT_1D receptor agonist sumatriptan (SUM) induced a cGH peak at 30 min of 12.9 ± 2.7 µg/l. The combined administration of GHRH plus SUM strikingly potentiated cGH release with a peak of 36.9 ± 6 µg/l at 30 min (p < 0.05). Pretreatment with the muscarinic receptor antagonist atropine completely abolished the cGH response to SUM, while the cholinergic agonist pyridostigmine (PYR) did not modify this response (15.3 ± 5 µg/l PYR plus SUM vs. SUM alone 12.9 ± 2.7 µg/l). On the other hand, administration of drugs with activity at 5-HT_2A/C receptors showed a stimulatory role for the 5-HT_2C receptor subtype, since LY-53857 (antagonist 5-HT_2A/C) and DOI agonist (5-HT_2A/C) both modified the GH response stimulated by GHRH (AUC 88.5 ± 30.4 and 400 ± 64.6 vs. 267.3 ± 52.6 respectively), while ketanserin (antagonist 5-HT_2A) did not modify this response. The 5-HT₃ antagonist ICS-205–930 failed to modify either basal or GHRH induced GH responses. In conclusion, our data show that 5-HT_1D receptors play a stimulatory role on GH secretion in the dog, possibly by acting through a decrease in hypothalamic somatostatin release. Similarly, the 5-HT_2C receptor subtypes also appear to play a stimulatory role. However, 5-HT_2A and 5-HT₃ receptors do not appear to be involved in the control of basal and GHRH-induced GH secretion.

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Sumatriptan mediated growth hormone responses do not alter throughout the menstrual cycle

Lavelle

Williams

Dinan

1996

Hum. Psychopharmacol. Clin. Exp.

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The objective of this study was to determine the effects of oral sumatriptan on growth hormone (GH) release throughout the menstrual cycle in healthy female volunteers. A placebo-controlled cross-over design was employed. Subjects were tested a total of six times over two consecutive menstrual cycles; twice in the early follicular phase, twice in midcycle and twice in the late luteal phase. Oral sumatriptan (100 mg) and placebo were administered on alternate visits. Twelve healthy female volunteers aged between 18-40 years with regular menses and not taking oral contraceptives were recruited. Baseline blood samples at 0 min were taken for GH, oestrogen and progesterone estimation. G H was measured at +60, +90, + 120 and + 180 min following administration of oral sumatriptan 100 mg or matched placebo. GH, progesterone and oestrogen were measured by radioimmunoassay. At each phase of the menstrual cycle serum GH levels peaked at 60-90 min following administration of oral sumatriptan compared to placebo which showed no response. Analysing GH response to sumatriptan and placebo over time for the three phases of the menstrual cycle (three-way ANOVA) demonstrates that the G H response to sumatriptan did not alter.

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The effects of sumatriptan on pituitary secretion in man

Cited by 31 publications

References 24 publications

The Relationship between Repetitive Behaviors and Growth Hormone Response to Sumatriptan Challenge in Adult Autistic Disorder

The Relationship between Repetitive Behaviors and Growth Hormone Response to Sumatriptan Challenge in Adult Autistic Disorder

Influence of Different Serotonin Receptor Subtypes On Growth Hormone Secretion

Sumatriptan mediated growth hormone responses do not alter throughout the menstrual cycle

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