The Effects of Sunitinib in Healthy and Cisplatin‐Induced Rats

Abstract

Sunitinib is a multitargeted kinase inhibitor that inhibits many receptor tyrosine kinases and has been used in the treatment of gastrointestinal stromal tumors, metastatic renal cell carcinoma, and pancreatic neuroendocrine tumors. In this study, the effects of sunitinib given to rats, both alone and after stress with cisplatin, were investigated. The animals were divided into four groups – (1) control group (C) administered interperitoneally with a single dose 0.9 % saline, (2) Cis group administered a single dose (7 mg/kg) of cisplatin, (3) Sun group administered 10 mg/kg sunitinib for seven days, and (4) Cis+Sun group administered 10 mg/kg sunitinib for seven days after a single dose (7 mg/kg) of cisplatin. After these applications, the rats were sacrificed, and blood and tissue samples were taken for biochemical and histopathological evaluations. Sunitinib did not show any effect on urea, creatine, and kidney IL1β and TGF‐β3 expression levels when administered alone; it increased ALT, AST, and IL‐38 levels. When sunitinib was given to the cisplatin‐induced rats, it was observed that the increase in ALT, AST, and IL‐38 levels increased more than the rats that was given only sunitinib. According to the data obtained, sunitinib does not cause a significant change in kidney tissue under both normal and stress conditions, while it creates stress in liver tissue. In addition, its toxicity in the liver becomes more certain as a result of its combination with cisplatin.

Investigation of the effect of Myricetin on Cisplatin-induced liver hepatotoxicity

“…It is known that Cis causes damage to many tissues, and one of these negative effects is liver hepatotoxicity 13 , 14 . Cis causes morphological changes in the arrangement of hepatocyte cords 15 .…”

“…Cis causes morphological changes in the arrangement of hepatocyte cords 15 . For example, in the liver, irregularity in the hepatic cords, portal triad fusion and central vein obstruction 16 , degenerative hepatocytes 14 , pyknosis of hepatocyte nuclei around the vena centralis in some and hypertrophy, inflammation, hypertrophy in some hepatocytes, vascular occlusion, sinusoidal dilatation 17 , and congestions are a few of them 18 .…”