The Effects of Synbiotic Supplementation on Carotid Intima-Media Thickness, Biomarkers of Inflammation, and Oxidative Stress in People with Overweight, Diabetes, and Coronary Heart Disease: a Randomized, Double-Blind, Placebo-Controlled Trial

Farrokhian, Alireza; Raygan, Fariba; Soltani, Alì; Tajabadi‐Ebrahimi, Maryam; Sharifi, Mehran; Karami, Ali Akbar; Asemi, Zatollah

doi:10.1007/s12602-017-9343-1

Cited by 49 publications

(44 citation statements)

References 47 publications

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“…Coronary atherosclerotic heart disease (CHD) is a CVD caused by stenosis or obstruction of the coronary artery [ 36 , 37 ]. It is characterized by the formation of lipid-filled atherosclerotic plaques under the tunica intima of the great and middle arteries, leading to stenosis or occlusion of the arterial lumen, which then causes myocardial ischemia and hypoxia [ 38 , 39 ].…”

Section: Application Of Antioxidant Natural Drugs For Cardiovasculmentioning

confidence: 99%

Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

Chang

Zhang

et al. 2020

Oxidative Medicine and Cellular Longevity

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Oxidative stress (OS) refers to the physiological imbalance between oxidative and antioxidative processes leading to increased oxidation, which then results in the inflammatory infiltration of neutrophils, increased protease secretion, and the production of a large number of oxidative intermediates. Oxidative stress is considered an important factor in the pathogenesis of cardiovascular disease (CVD). At present, active components of Chinese herbal medicines (CHMs) have been widely used for the treatment of CVD, including coronary heart disease and hypertension. Since the discovery of artemisinin for the treatment of malaria by Nobel laureate Youyou Tu, the therapeutic effects of active components of CHM on various diseases have been widely investigated by the medical community. It has been found that various active CHM components can regulate oxidative stress and the circulatory system, including ginsenoside, astragaloside, and resveratrol. This paper reviews advances in the use of active CHM components that modulate oxidative stress, suggesting potential drugs for the treatment of various CVDs.

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Section: Application Of Antioxidant Natural Drugs For Cardiovasculmentioning

confidence: 99%

Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

Chang

Zhang

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Therefore, the type of bacterial strains used and even the duration of the intervention may cause differences in these results. Some other studies also showed that synbiotic supplementation could decrease hs-CRP concentration [19,33,34]. The proposed mechanism for the effect of probiotics and prebiotics on serum levels of hs-CRP is due to the extrahepatic effects of these supplements by reducing adipose tissue mass and subsequently decreasing IL-6 by adipose tissue, hepatocyte stimulation is lessened, resulting in lower amounts of hs-CRP being synthesized.…”

Section: Discussionmentioning

confidence: 99%

The effects of synbiotic supplementation on metabolic factors and systemic inflammation in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study

Velayati

Kareem

Sedaghat

et al. 2020

Preprint

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Background: Type 2 diabetes is a common metabolic disorder in the world, and it has become a challenge for the health system. Some studies have indicated the desirable effects of synbiotics on metabolic factors in patients with diabetes. Aim: This study aimed to determine the effect of synbiotic supplementation on metabolic factors and systemic inflammation in patients with type 2 diabetes mellitus. Methods: In this randomized, double-blind controlled trial, 50 patients with type 2 diabetes randomly allocated to the synbiotic (containing Bacillus coagulans + Lactobacillus rhamnosus + Lactobacillus acidophilus and fructooligosaccharide) or placebo groups to received one sachet daily for 12 weeks. Glycemic index, Lipid profile, and hs-CRP measured at the beginning of the study and the end of the 12th week. Results: After 12 weeks, supplementation means a change of Hip circumference (HC) significantly decreased in the synbiotic group compared to the placebo group (-0.85±1.89 vs. 1.23±3.98). Although systolic blood pressure (SBP) and diastolic blood pressure (DBP) at the end of trial declined in the synbiotic group compared to baseline, respectively p=0.03, p=0.01. Analysis of covariance demonstrated that synbiotic supplementation during 12 weeks significantly reduced glycemic factors including fasting blood glucose (FBG), insulin, homeostatic Model Assessment for Insulin Resistance (HOMA-IR), β-cell function (HOMA-β) (p<0.05) and inflammatory index, hs-CRP (p<0.05) compared to placebo. Conclusion: The current study indicated Synbiotic supplementation could improve glycemic index, systemic inflammation and blood pressure in patients with type 2 diabetes. So correcting the intestinal microbial flora can be a new therapeutic approach to treating this disease. Trial registration: IRCT, IRCT20100524004010N27. Registered 7 January 2019, https://www.irct.ir/trial/36535

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“…It is generally accepted that atherosclerosis is an inflammatory disease, as abnormal activation of immune cells, excessive inflammatory mediators released, excessive inflammatory reactions, damage to coronary endothelial cells, causing platelet aggregation, thrombosis, which accelerated the formation of coronary atherosclerotic plaques, severe even porridge plaque rupture and induced myocardial infarction or acute angina attacks ( 20 ). Immune cells in patients with coronary heart disease repeatedly activated, apoptosis, resulting in decreased immune cells, impaired immune function, varying degree of decreased immune function in coronary heart disease patients.…”

Section: Discussionmentioning

confidence: 99%

The expression level of miR-155 in plasma and peripheral blood mononuclear cells in coronary artery disease patients and the associations of these levels with the apoptosis rate of peripheral blood mononuclear cells

Zhao

Sun

et al. 2018

Exp Ther Med

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The aim of the study was to investigate the expression of miR-155 in plasma and peripheral blood mononuclear cells (PBMCs), the effects of miR-155 on the apoptosis rate of PBMCs and the extent of coronary stenosis in coronary artery disease patients. Seventy chest pain patients were divided into three groups by symptoms, signs, auxiliary examination and coronary arteriography: 21 cases in the acute myocardial infarction group (AMI), 23 cases in the Angor pectoris group (AP) and 26 cases in the control group (CT). The peripheral blood mononuclear cells of the patients in the three groups were separated for cell culture. Annexin V/propidium iodide (PI) was performed to analyze cell apoptosis. RT-qPCR was used to evaluate the expression level of miR-155 in plasma and PBMCs. There were significant differences on the expression of miR-155 in plasma and PBMCs, the apoptosis rate of PBMCs, Gensini score and the extent of coronary stenosis among the three groups (P<0.05). The expression of miR-155 in plasma and PBMCs in AMI and AP group were lower than CT group while the AMI group was lower than the AP group (P<0.05). The apoptotic rate of PBMCs, Gensini score and the extent of coronary stenosis of the AMI and AP groups were higher than CT group while the AMI group was higher than the AP group (P<0.05). The expression of miR-155 in plasma was positively correlated with PBMCs, but negatively correlated with the apoptosis rate of PBMCs, Gensini score and the extent of coronary stenosis. The apoptosis rate of PBMCs in patients with coronary heart disease was positively correlated with the degree of coronary artery stenosis and Gensini score. In conclusion, in the patients with coronary heart disease the apoptosis rate of PBMCs was increased and the expression of miR-155 in plasma and PBMCs cells was decreased, which were correlated with the severity of coronary heart disease.

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The Effects of Synbiotic Supplementation on Carotid Intima-Media Thickness, Biomarkers of Inflammation, and Oxidative Stress in People with Overweight, Diabetes, and Coronary Heart Disease: a Randomized, Double-Blind, Placebo-Controlled Trial

Cited by 49 publications

References 47 publications

Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

The effects of synbiotic supplementation on metabolic factors and systemic inflammation in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study

The expression level of miR-155 in plasma and peripheral blood mononuclear cells in coronary artery disease patients and the associations of these levels with the apoptosis rate of peripheral blood mononuclear cells

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