The Effects of Synbiotic Supplementation on Metabolic Status in Women With Polycystic Ovary Syndrome: a Randomized Double-Blind Clinical Trial

Samimi, Mansooreh; Dadkhah, Adeleh; Kashani, Hamed Haddad; Tajabadi‐Ebrahimi, Maryam; Hosseini, Elahe Seyed; Asemi, Zatollah

doi:10.1007/s12602-018-9405-z

Cited by 42 publications

(38 citation statements)

References 45 publications

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“…53 Interestingly, administration of a synbiotic formula to women suffering from polycystic ovary syndrome for 12 weeks resulted in decreased levels of plasma glucose, triglyceride, and cholesterol levels. 62 Importantly, it was previously found that certain Lactobacillus strains isolated from human breast milk could combat cervical cancer via inducing apoptosis and inhibiting proliferation. 63 In particular, L. casei potentiated the antiproliferative effect of geniposide through the production of b-glucosidase in oral squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Modulation of JNK-1/ β-catenin signaling byLactobacillus casei, inulin and their combination in 1,2-dimethylhydrazine-induced colon cancer in mice

et al. 2019

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Colon cancer is a complex disease that involves numerous genetic alterations that change the normal colonic mucosa into invasive adenocarcinoma. In the current study, the protective effects of inulin (prebiotic), Lactobacillus casei (L. casei, probiotic) and their combination (synbiotic) on 1,2dimethylhydrazine (DMH)-induced colon cancer in male Swiss mice were evaluated. Animals were divided into: Control group, DMH-treated group, DMH plus inulin, DMH plus L. casei and DMH plus inulin plus L. casei-treated groups. Fecal microbiome analysis, biochemical measurements, histopathological examination of the colon tissues, immunostaining and Western blotting analysis of bcatenin, GSK3b and JNK-1 were performed. The prebiotic-, probiotic-and synbiotic-treated groups showed decreased levels of carcinoembryonic antigen and a lower number of aberrant crypt foci compared to the DMH-treated group with the synbiotic group exhibiting a superior effect. Furthermore, all treatments showed a body weight-reducing effect. Administration of inulin, L. casei or their combination increased the expression level of phospho-JNK-1 while they decreased the expression level of b-catenin and phospho-GSK3b. Remarkably, L. casei treatment resulted in enrichment of certain beneficial bacterial genera i.e. Akkermansia and Turicibacter. Therefore, administration of L. casei and inulin as a synbiotic combination protects against colon cancer in mice.

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Section: Discussionmentioning

confidence: 99%

Modulation of JNK-1/ β-catenin signaling byLactobacillus casei, inulin and their combination in 1,2-dimethylhydrazine-induced colon cancer in mice

et al. 2019

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“…bulgaricus , S. thermophilus , L. paracasei ssp . paracasei (2.4×10 9 CFU per day) 113 Adults with T1DM and T2DM on haemodialysis, n = 60 Inulin (0.8 g per day) L. acidophilus , L. casei , B. bifidum (2×10 9 CFU of each per day) 114 Treatment of irritable bowel syndrome Adults, n = 85 FOS (100 mg, three times per day) Bacillus coagulans (15×10 7 spores, three times per day) 115 Children, n = 71 Inulin (900 mg, twice per day) B. lactis B94 (5×10 9 CFU, twice per day) 116 Eradication of Helicobacter pylori Adults, n = 76 FOS (250 mg per day) L. casei PXN 37, L. rhamnosus PXN 54, S. thermophilus PXN 66, B. breve PXN 25, L. acidophilus PXN 35, B. longum PXN 30, L. bulgaricus PXN 39 (2×10 8 CFU per day) 117 Children and youth, n = 104 Inulin (900 mg per day) B. lactis B94 (5×10 9 CFU per day) 118 Treatment of polycystic ovarian syndrome Adults, n = 60 Inulin (800 mg per day) L. acidophilus strain T16 (IBRC-M10785), L. casei strain T2 (IBRC-M10783), B. bifidum strain T1 (IBRC-M10771) (2×10 9 CFU/g of each per day) 119 Adults, n = 60 Inulin (800 mg per day) L. acidophilus strain T16 (IBRC-M10785), L. casei strain T2 (IBRC-M10783), B. bifidum strain T1 (IBRC-M10771) (2×10 9 CFU/g of each per day) 120 Treatment of chronic kidney disease Adults, n = 30 Inulin (2.2 g), tapioca-resistant starch (1.3 g) (three times per day) L. plantarum (5×10 9 ), L. casei subsp. r hamnosus (2×10 9 ), Lactobacillus gasseri (2×10 ...…”

Section: Current Levels Of Evidencementioning

confidence: 99%

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

Swanson

Gibson

Hutkins

et al. 2020

Nat Rev Gastroenterol Hepatol

1,109

455

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In May 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the definition and scope of synbiotics. The panel updated the definition of a synbiotic to “a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host”. The panel concluded that defining synbiotics as simply a mixture of probiotics and prebiotics could suppress the innovation of synbiotics that are designed to function cooperatively. Requiring that each component must meet the evidence and dose requirements for probiotics and prebiotics individually could also present an obstacle. Rather, the panel clarified that a complementary synbiotic, which has not been designed so that its component parts function cooperatively, must be composed of a probiotic plus a prebiotic, whereas a synergistic synbiotic does not need to be so. A synergistic synbiotic is a synbiotic for which the substrate is designed to be selectively utilized by the co-administered microorganisms. This Consensus Statement further explores the levels of evidence (existing and required), safety, effects upon targets and implications for stakeholders of the synbiotic concept.

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“…Patients were examined by the otolaryngologist at the clinic and diagnosed with chronic sinusitis based on clinical observations and CT scan findings. After obtaining written consent, patients were randomly assigned to three groups using a randomized block table [13][14][15][16][17]. Patients in the first group received dexmedetomidine infusion at a dose of 2. μg/kg Patients in the second group received dexmedetomidine infusion at a dose of 0.5. μg/kg patients in the third group receive normal saline as a placebo.…”

Section: Methodsmentioning

confidence: 99%

Effect of intraoperative dexmedetomidine infusion during functional endoscopic sinus surgery: a prospective cohort study

et al. 2020

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Background Dexmedetomidine, an α2 agonist, has well-known anesthetic and analgesic-sparing effects. We designed this study to evaluate the effect of intraoperative dexmedetomidine infusion on intra operative blood loss and postoperative pain in functional endoscopic sinus surgery. Methods This prospective cohort study included 90 patients planning to undergo endoscopic sinus surgery, who were randomly divided into three groups. 2 to 2.5 mg/kg of propofol was used in all groups to induce anesthesia. One group received dexmedetomidine 0.2 μg/kg per hour infusion whereas the other group received dexmedetomidine 0.5 μg/kg per hour infusion. The control group received normal saline infusion. Results The mean age of patients was 41.02 ± 11.93. 33 patients in the dexmedetomidine 0.2 μg/kg/h group, 30 patients in the dexmedetomidine 0.5 μg/kg/h group and 27 patients in the placebo group. The lowest amount of bleeding was related to the dexmedetomidine 0.5 μg/kg/h group. The volume of bleeding between the three groups was significantly different (p = 0.012). The satisfaction of the surgeon in the dexmedetomidine 0.5 μg/kg/h group was more than other groups. There was a significant relationship between the satisfaction of the surgeon and the treatment groups (p < 0.001). The lowest duration of surgery was related to the dexmedetomidine 0.2 μg/kg/h group. The most Trinitroglycerin (TNG) consumption was in the placebo group and the highest dose of labetalol was in the dexmedetomidine 0.5 μg/kg/h group. There was no significant difference in the TNG and labetalol consumption between three groups. The lowest consumption of morphine and pethidine in the dexmedetomidine 0.5 μg/kg/h group. Conclusions Infusion of dexmedetomidine 0.5 μg/kg/h decreased blood loss and consumption of morphine and pethidine in patients who underwent endoscopic sinus surgery.

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The Effects of Synbiotic Supplementation on Metabolic Status in Women With Polycystic Ovary Syndrome: a Randomized Double-Blind Clinical Trial

Abstract: www.irct.ir : IRCT201604015623N71.

Cited by 42 publications

References 45 publications

Modulation of JNK-1/ β-catenin signaling byLactobacillus casei, inulin and their combination in 1,2-dimethylhydrazine-induced colon cancer in mice

Modulation of JNK-1/ β-catenin signaling byLactobacillus casei, inulin and their combination in 1,2-dimethylhydrazine-induced colon cancer in mice

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

Effect of intraoperative dexmedetomidine infusion during functional endoscopic sinus surgery: a prospective cohort study

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