The effects of tegaserod on oesophageal function and bolus transport in healthy volunteers: studies using concurrent high‐resolution manometry and videofluoroscopy

Fox, Mark; Menne, Dieter; Stutz, B.; Fried, Michael; Schwizer, Werner

doi:10.1111/j.1365-2036.2006.03090.x

Cited by 63 publications

(79 citation statements)

References 28 publications

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“…Furthermore, in ineffective swallows the site of bolus escape coincided with the position of the transition zone or pressure trough on manometry. In a subsequent study in healthy volunteers they showed that a 7-day course of the prokinetic tegaserod promoted mid-esophageal contractility and shortened the pressure transition zone, the level at which bolus escape occurred most frequently [25]. These are encouraging studies and suggest possible clinical usefulness of high-resolution manometry in identifying focal abnormalities of esophageal function that respond to specific management.…”

Section: Evaluation Of Dysphagiamentioning

confidence: 86%

High-resolution manometry – bliss upon bliss for esophagology?

Bredenoord

2007

Eur Surg

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Zusammenfassung. Grundlagen: Ö sophagus-Manometrie dient der Abklä rung funktioneller Stö rungen der Speiserö hre.Methodik: Ü bersicht zu Manometrie und hochauflö sender ''High Resolution''-Manometrie (HR-Manometrie).Ergebnisse: Indikationen fü r Manometrie sind: Endoskopie-negative Dysphagie, nicht-kardialer Brustschmerz, Verdacht auf Systemerkrankung mit Beteiligung der Speiserö hre, Abklä rung vor Fundoplikatio inklusive Erhebung der Position der pH-Metriesonde. Im Gegensatz zur konventionellen Manometrie erlaubt die HR-Manometrie eine hö here Auflö sung wie die Durchzugsmanometrie und ist mit der Sleeve-Manometrie zu vergleichen. Die Untersuchungszeit ist bei der HR-Manometrie deutlich kü rzer.Schlussfolgerungen: HR-Manometrie ermö glicht eine rasche und attraktive Darstellung der Druckverhä ltnisse im Ö sophagus. Zukü nftige Studien werden die Vorzü ge der HR-Manometrie bestimmen.Schlü sselwö rter: Dysphagie, Manometrie, Refluxkrankheit, Achalasie, Ö sophagus.Summary. Background: Esophageal manometry is a widely accepted technique for evaluation of esophageal symptoms. With esophageal manometry the clinician and researcher gather information on the function of neuromuscular processes in the esophagus and this allows identification of specific motor function abnormalities.Methods: A review of the available literature on esophageal manometry with a special emphasis on high-resolution manometry.Results: Indications for esophageal manometry are considered: endoscopy-negative dysphagia, noncardiac chest pain, to document the involvement of the esophagus in systemic disorders, to document esophageal motility prior to antireflux surgery and for placement of a pH probe. Conventional, stationary manometry can not be performed to confirm or rule out the presence of gastroesophageal reflux disease. Recently, high-resolution manometry was introduced. Current studies suggest that the yield of highresolution manometry is higher than that of conventional pull-through manometry and is at least comparable to that of sleeve sensor manometry. Probably the most important advantage of high-resolution manometry is that it makes esophageal manometry much faster and easier to perform and to interpret.Conclusions: High-resolution manometry and topographic plotting of signals are a visually attractive way of presenting data; further studies will determine whether it is genuinely superior to conventional manometry.

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Section: Evaluation Of Dysphagiamentioning

confidence: 86%

High-resolution manometry – bliss upon bliss for esophagology?

Bredenoord

2007

Eur Surg

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“…31 While conventional manometry did not establish the physiological basis of this effect, the use of HRM revealed that Tegaserod promoted midesophageal contractility and shortened the proximal transition zone. 32 Another preliminary study suggests that HRM may identify specific dysmotility patterns that respond to specific pharmacologic intervention. For example, symptomatic focal spasm was shown to respond to sildenafil.…”

Section: Effect Of Medicationsmentioning

confidence: 99%

High-resolution Esophageal Manometry: Using Technical Advances for Clinical Advantages

Ayazi

Crookes

2010

Journal of Gastrointestinal Surgery

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“…22 Several studies have evaluated the effects of 5-HT 4 agonists on esophageal peristalsis and LES function in non-SSc patients, showing different results. [23][24][25][26][27] However, use of these agents is restricted due to cardiac safety profile issues. Another serotonin receptor agonist, namely the 5-HT1A receptor agonist sumatriptan, may enhance esophageal peristalsis after subcutaneous administration in healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effect of the 5‐HT_1A receptor agonist buspirone on esophageal dysfunction associated with systemic sclerosis: A pilot study

et al. 2015

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Background: Esophageal involvement in systemic sclerosis (SSc) carries significant morbidity and is empirically managed with domperidone, albeit with questionable efficacy. The oral 5-HT 1A receptor agonist buspirone may enhance esophageal peristalsis and lower esophageal sphincter (LES) function in healthy volunteers. Aim: We aimed to test the hypothesis that buspirone may exert a beneficial acute effect on esophageal motor dysfunction in symptomatic patients with SSc. Methods: Twenty consecutive patients with SSc reporting esophageal symptoms underwent high-resolution manometry before and 30 minutes after administration of buspirone (10 mg). Ten other patients received domperidone (10 mg) and served as control group. Changes in LES resting and residual pressure, amplitude, duration, and velocity of distal esophageal body contractions were examined. Results: Esophageal hypomotility and hypotensive LES was found in 63% and 67% of patients, respectively. Demographic and clinical characteristics, including baseline manometric parameters, were comparable between groups. Resting pressure of LES increased after buspirone from 9.42 AE 2.6 to 11.53 AE 3.4 mmHg (p ¼ 0.0002 by paired t-test), but not after domperidone; a trend for increase of amplitude of contractions was also observed after buspirone (p ¼ 0.09). Comparison of the individual changes revealed that buspirone was superior to domperidone in enhancing LES pressure ( þ 2.11 AE 2.0 versus -0.45 AE 2.3 mmHg, p ¼ 0.006). No significant effects of either drug were noted on other examined parameters of esophageal function. Conclusion: The beneficial acute effect of buspirone on impaired LES function associated with SSc suggests a role of 5-HT 1A receptor-mediated interactions in these patients. Prospective studies to examine whether buspirone is of long-term therapeutic value for SSc-associated esophageal disease are warranted.

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The effects of tegaserod on oesophageal function and bolus transport in healthy volunteers: studies using concurrent high‐resolution manometry and videofluoroscopy

Abstract: SUMMARY BackgroundTegaserod is a partial 5-hydroxytryptamine 4 receptor agonist with prokinetic effects on the gastrointestinal tract, its effects on oesophageal function are unknown.

Cited by 63 publications

References 28 publications

High-resolution manometry – bliss upon bliss for esophagology?

High-resolution manometry – bliss upon bliss for esophagology?

High-resolution Esophageal Manometry: Using Technical Advances for Clinical Advantages

Beneficial effect of the 5‐HT_1A receptor agonist buspirone on esophageal dysfunction associated with systemic sclerosis: A pilot study

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The effects of tegaserod on oesophageal function and bolus transport in healthy volunteers: studies using concurrent high‐resolution manometry and videofluoroscopy

Abstract: SUMMARY BackgroundTegaserod is a partial 5-hydroxytryptamine 4 receptor agonist with prokinetic effects on the gastrointestinal tract, its effects on oesophageal function are unknown.

Cited by 63 publications

References 28 publications

High-resolution manometry – bliss upon bliss for esophagology?

High-resolution manometry – bliss upon bliss for esophagology?

High-resolution Esophageal Manometry: Using Technical Advances for Clinical Advantages

Beneficial effect of the 5‐HT1A receptor agonist buspirone on esophageal dysfunction associated with systemic sclerosis: A pilot study

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Beneficial effect of the 5‐HT_1A receptor agonist buspirone on esophageal dysfunction associated with systemic sclerosis: A pilot study