The effects of terpenes on the permeation of lidocaine and ofloxacin from moisture-activated patches

Song, Yeon Hwa; Gwak, Hye Sun; Chun, In‐Koo

doi:10.1080/10717540802586667

Cited by 16 publications

(11 citation statements)

References 13 publications

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“…The maleic anhydride in Gantrez reacts with hydroxyl in Natrosol with the help of NaOH as catalyst, undergoing esterification reaction to form the gel network. Kollidon VA is added to the system as a plasticizer, and HPCD is used to increase the solubility and dispersibility of the drugs . The bioadhesive strength of this particular hydrogel to neonate porcine skin was reported to be between 0.75 and 1.5 N cm −2 depending on the pH …”

Section: Resultsmentioning

confidence: 99%

Application of Monodirectional Janus Patch to Oromucosal Delivery System

You

Choi

Baek

et al. 2015

Adv Healthcare Materials

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Drug delivery through mucosae has received huge research attention owing to its advantageous characteristics such as accurate dose control and the avoidance of premature metabolism of vulnerable drugs by oral administration. However, body fluid in mucosae may dissolve the drug, releasing it to unwanted directions. Here, a Janus drug delivery patch with monodirectional diffusion property is devised to deliver drugs efficiently and to overcome the issue of unwanted drug release. A polyester fabric is coated with a hydrophobic polymer, poly(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10-heptadecafluorodecyl methacrylate), via initiated chemical vapor deposition. Subsequently, hydrophilicity is rendered selectively on one surface by base-catalyzed hydrolysis to obtain a Janus substrate with both hydrophobic and hydrophilic surfaces. The hydrophilic surface of the Janus substrate is further coated with resveratrol-loaded hydrogel to produce a Janus drug delivery patch. The fabricated patch efficiently blocks fluid penetration from one side to the other in mucous environment. Delivery of resveratrol through hairless mouse skin and reconstructed human mucosae using Janus patch shows higher permeation flux compared to bare control patch. The Janus drug delivery patch shown in this study can be a useful tool for efficient transmucosal delivery of various kinds of drugs.

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Section: Resultsmentioning

confidence: 99%

Application of Monodirectional Janus Patch to Oromucosal Delivery System

You

Choi

Baek

et al. 2015

Adv Healthcare Materials

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“…A possible explanation for the enhanced effect is that a fragrance in a mixture may act as a penetration enhancer for other ingredients present [116]. This penetration enhancement effect has been shown for terpenes, and is used in the field of transdermal drug delivery [117,118]. This is also relevant for essential oils which are, in effect, complex mixtures of fragrance compounds.…”

Section: Exposurementioning

confidence: 99%

Fragrance Allergens, Overview with a Focus on Recent Developments and Understanding of Abiotic and Biotic Activation

2016

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Fragrances and fragranced formulated products are ubiquitous in society. Contact allergies to fragrance chemicals are among the most common findings when patch-testing patients with suspected allergic contact dermatitis, as well as in studies of contact allergy in the general population. The routine test materials for diagnosing fragrance allergy consist mainly of established mixes of fragrance compounds and natural extracts. The situation is more complex as several fragrance compounds have been shown to be transformed by activation inside or outside the skin via abiotic and/or biotic activation, thus increasing the risk of sensitization. For these fragrance chemicals, the parent compound is often non-allergenic or a very weak allergen, but potent sensitizers will be formed which can cause contact allergy. This review shows a series of fragrance chemicals with well-documented abiotic and/or biotic activation that are indicative and illustrative examples of the general problem. Other important aspects include new technologies such as ethosomes which may enhance both sensitization and elicitation, the effect on sensitization by the mixtures of fragrances found in commercial products and the effect of antioxidants. A contact allergy to fragrances may severely affect quality of life and many patients have multiple allergies which further impact their situation. Further experimental and clinical research is needed to increase the safety for the consumer.

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“…Studies carried out over the past 15 years have shown that menthol is able to increase the transdermal (Kunta, Goskonda, Brotherton, Khan, & Reddy, 1997;Song, Gwak, & Chun, 2009;Yamato et al 2009) and transbuccal (Shojaei, Khan, Lim, & Khosravan, 1999) penetration of dideoxycytidine, propofol, propanolol, and ofloxacin. More recently, Azzi et al (2006) have shown that menthol increases the flux of the tobacco-related…”

Section: Introductionmentioning

confidence: 99%

Effect of menthol on the penetration of tobacco carcinogens and nicotine across porcine oral mucosa ex vivo

Squier

Mantz

Wertz

2010

Nicotine & Tobacco Research

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Menthol enhances penetration of NNN and nicotine through FM and BM in vitro, even after short exposure. This may reflect loading of a superficial epithelial reservoir (Squier, C. A., Kremer, M. J., Bruskin, A., Rose, A., & Haley, J. D., 1999. Oral mucosal permeability and stability of transforming growth factor beta-3 in vitro. Pharmaceutical Research, 16, 1557-1563.), thus delivering menthol and enhancing flux for several hours. Practical implications are for a potentially increased oral exposure to carcinogens among users of menthol-flavored cigarettes and chewing tobacco.

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The effects of terpenes on the permeation of lidocaine and ofloxacin from moisture-activated patches

Cited by 16 publications

References 13 publications

Application of Monodirectional Janus Patch to Oromucosal Delivery System

Application of Monodirectional Janus Patch to Oromucosal Delivery System

Fragrance Allergens, Overview with a Focus on Recent Developments and Understanding of Abiotic and Biotic Activation

Effect of menthol on the penetration of tobacco carcinogens and nicotine across porcine oral mucosa ex vivo

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