The Effects of Testosterone and of Testosterone Propionate on Renal Functions in Man

Klopp, Calvin T.; Young, Nelson F.; Taylor, Howard C.

doi:10.1172/jci101596

Cited by 14 publications

(4 citation statements)

References 7 publications

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“…It is possible that androgens may have a direct effect on proximal sodium reabsorption in the kidney. Many studies have been performed to assess the effect of testosterone on kidneys of humans and animals 38 –40 . However, there have been no studies in which the androgen receptor has been localized in the kidney.…”

Section: Testosterone‐induced Reduction In Pressure‐natriuresismentioning

confidence: 99%

“…Many studies have been performed to assess the effect of testosterone on kidneys of humans and animals. [38][39][40] However, there have been no studies in which the androgen receptor has been localized in the kidney. The fact that androgen receptors are present in the kidney is likely because the receptor has been found in nuclear fractions of KJ29, a kidney carcinoma cell line that retains morphological and functional character- istics of proximal tubule cells.…”

Section: Role Of Androgen Receptorsmentioning

confidence: 99%

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Role of Androgens in Mediating Hypertension and Renal Injury

Reckelhoff

Granger

1999

Clin Exp Pharma Physio

104

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1. Men are generally at greater risk for cardiovascular disease than are women, particularly with regard to enhanced progression of hypertension and loss of renal function. Despite these gender differences in the progression of hypertension and renal disease in humans and animals, the mechanisms responsible are unknown. 2. Castration in males has been shown to slow the progression of hypertension and ameliorate the loss in renal function. When serum testosterone was measured in the developing male spontaneously hypertensive rat (SHR), the peak serum testosterone level at 12 weeks coincided with the time when differences in systolic blood pressure could be measured between intact male SHR and females or castrated male SHR. Ovariectomy does not affect blood pressure in female SHR but testosterone treatment of ovariectomized females for 5 weeks results in exacerbation of hypertension almost to the level found in intact male SHR. These data strongly suggest a role for androgens in mediating the gender differences in hypertension. 3. The mechanisms by which androgens could increase blood pressure are not known. We have recently shown that, at comparable renal perfusion pressures, there is a hypertensive shift in the pressure-natriuresis relationship in male SHR compared with females or castrated male SHR. Testosterone treatment of ovariectomized female SHR also causes a rightward shift in the pressure-natriuresis relationship. 4. We hypothesize that androgens increase arterial pressure by causing a hypertensive shift in the pressure-natriuresis relationship, either by having a direct effect to increase proximal tubular reabsorption or by activation of the renin-angiotensin system. We also hypothesize that the enhanced proximal tubular reabsorption leads to a tubuloglomerular feedback-mediated afferent vasodilation, which, in combination with the increase in arterial pressure, results in glomerular hypertension and renal injury.

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Section: Testosterone‐induced Reduction In Pressure‐natriuresismentioning

confidence: 99%

Section: Role Of Androgen Receptorsmentioning

confidence: 99%

Role of Androgens in Mediating Hypertension and Renal Injury

Reckelhoff

Granger

1999

Clin Exp Pharma Physio

104

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“…Testosterone propionate was found to increase the maximal capacity of the kidney tubules to excrete diodrast in castrated female dogs (5). No increase of renal function could be demonstrated when the same hormone was given to normal men, a eunuchoid male, and patients with kidney disease (6,7), even when the dose was as large as 300 mg. per diem. Nevertheless, since the renotrophic action is believed to affect mainly the tubular cells and since in some cases of Addison's disease atrophy of these cells has been described (8 to 10) it was thought advisable to observe the influence of hormone therapy on the kidney by means of the more refined tests of renal function which are now available.…”

mentioning

confidence: 91%

Kidney Function in Adrenal Insufficiency 1

Waterhouse

Keutmann²,

Cusson³

1948

J. Clin. Invest.

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“…Roe and Mitchley, (1962) reported that in female CBA mice, the administration of 1 mg. testosterone once weekly for 30 weeks caused (a) a reduction in body weight, (b) an increase in the kidney weight/body weight, kidney weight/liver weight, and kidney weight/heart + lung weight ratios up to, or above, the values normally found in male CBA mice. Klopp, Young and Taylor (1945) investigated, with negative result, the possibility that testosterone might benefit patients with renal failure.…”

mentioning

confidence: 99%