The effects of testosterone treatment in Klinefelter's syndrome

Myhre, Selma A.; Ruvalcaba, R. H. A.; Johnson, H.R.; Thuline, Horace C.; Kelley, Vincent C.

doi:10.1016/s0022-3476(70)80173-1

Cited by 55 publications

(23 citation statements)

References 20 publications

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“…63 This therapy results in an increase in facial and pubic hair, a more masculine distribution of body fat, more goal-directed thinking, improved self-esteem, less fatigue and irritability, and increased libido, strength, and bone mineral density. 24,52,53,56 The optimal time to initiate testosterone replacement therapy is at the beginning of puberty, about age 11 or 12 years. 18,52 This timing permits boys with KS to experience pubertal changes similar to their peers and allows testosterone to have its most marked effects on bone mineral density.…”

Section: Treatmentmentioning

confidence: 99%

Klinefelter Syndrome

Smyth¹,

Bremner²

1998

Arch Intern Med

245

171

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Klinefelter syndrome is the most common sex chromosome disorder. Affected males carry an additional X chromosome, which results in male hypogonadism, androgen deficiency, and impaired spermatogenesis. Some patients may exhibit all of the classic signs of this disorder, including gynecomastia, small testes, sparse body hair, tallness, and infertility, whereas others, because of the wide variability in clinical expression, lack many of these features. Treatment consists of testosterone replacement therapy to correct the androgen deficiency and to provide patients with appropriate virilization. This therapy also has positive effects on mood and self-esteem and has been shown to protect against osteoporosis, although it will not reverse infertility. Although the diagnosis of Klinefelter syndrome is now made definitively using chromosomal karyotyping, revealing in most instances a 47,XXY genotype, the diagnosis also can be made using a careful history and results of a physical examination, with the hallmark being small, firm testes. As it affects 1 in 500 male patients and presents with a variety of clinical features, primary care physicians should be familiar with this condition.

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Section: Treatmentmentioning

confidence: 99%

Klinefelter Syndrome

Smyth¹,

Bremner²

1998

Arch Intern Med

245

171

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“…It has been proposed that adolescent boys with KS may benefit from early T therapy (11)(12)(13)(14)(15). Reports, however, are lacking that verify hypoandrogenism in 47,XXY boys during puberty or examine their androgen status before the start of treatment (11)(12)(13)(14)(15).…”

mentioning

confidence: 99%

“…Reports, however, are lacking that verify hypoandrogenism in 47,XXY boys during puberty or examine their androgen status before the start of treatment (11)(12)(13)(14)(15). Consequently, the optimal age for initiating androgen therapy remains unclear.…”

mentioning

confidence: 99%

Are Adolescent Boys with Klinefelter Syndrome Androgen Deficient? A Longitudinal Study of Finnish 47,XXY Boys

et al. 2006

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Testosterone (T)-substitution therapy is widely used in adult patients with Klinefelter syndrome (KS) to prevent symptoms and sequels of androgen deficiency, but it is currently unknown if adolescent boys with KS benefit from early T therapy. To evaluate the optimal age to start T substitution, we searched for signs of androgen deficiency in pubertal boys with KS. 14 nonmosaic 47,XXY boys, aged 10 -13.9 y, were followed up for 4 -37 mo with staging of puberty and frequent reproductive hormone measurements. Furthermore, indices reflecting androgen action (serum SHBG, leptin, and prostate-specific antigen (PSA) levels) were studied. Both onset and progression of puberty according to Tanner stages were normal in boys with KS. Consistently, serum T concentrations increased as expected and remained normal throughout follow-up. Changes in the indices of androgen action (decreases in serum SHBG and leptin, and increase in serum PSA concentrations) occurred normally, except that average leptin levels were higher in the boys with KS (KS boys 11.8 Ϯ 7.0 g/L; controls 7.6 Ϯ 4.7 g/L; p ϭ 0.033). Despite normal T concentrations, the KS boys displayed from the age of 13 y elevated serum FSH and LH levels, and exaggerated gonadotropin responses to gonadotropin-releasing hormone. These data do not demonstrate an unequivocal androgen deficiency in adolescent boys with KS that would necessitate androgen supplementation therapy during early puberty.

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“…Jel preperatları kullanırken özellikle kadın partner kontaminasyonuna dikkat edilmesi gerekir. Testosteron tedavisinin jinekomasti üzerine etkisi olmadığı gösterilmiştir(27). Erişkin hastalarda testosteron tedavisi ile jinekomasti gerilemeyeceği gibi, pubertal hastalarda tedaviye rağmen jinekomasti gelişebilir.…”

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Klinefelter Syndrome

Peynirci¹,

Ertürk²

2013

Tjem

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Klinefelter syndrome is the most common sex chromosome disorder in males. Variation in clinical presentation and insufficient awareness of this syndrome among clinicians lead to fifty percent of patients remain undetected. Typical clinical features of Klinefelter syndrome are various degrees of hypogonadal symptoms, atrophic testes and gynaecomastia. However, these typical clinical symptoms may not be present in all patients. Even if serum testosterone levels are not markedly low, elevated serum follicle-stimulating hormone is a considerable laboratory finding. Definitive diagnosis is made by karyotype analysis of peripheral blood lymphocytes. It must be kept in mind that this analysis may be normal in rare conditions. Early recognition of patients during puberty and handling them as soon as possible is important. Testosterone replacement therapy results in increased muscle mass, bone mineral density and libido. The patient’s mood and self-esteem improve significantly. In general, patients with Klinefelter syndrome are accepted as infertile, however, assisted reproductive techniques may provide fertilization. Turk Jem 2013; 17: 63-

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The effects of testosterone treatment in Klinefelter's syndrome

Cited by 55 publications

References 20 publications

Klinefelter Syndrome

Klinefelter Syndrome

Are Adolescent Boys with Klinefelter Syndrome Androgen Deficient? A Longitudinal Study of Finnish 47,XXY Boys

Klinefelter Syndrome

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