The Effects of the Adenosine Receptor Antagonists on the Reverse of Cardiovascular Toxic Effects Induced by Citalopram In-Vivo Rat Model of Poisoning

Buyukdeligoz, Mujgan; Hocaoğlu, Nil; Oransay, Kubilay; Tunçok, Yeşim; Kalkan, Şule

doi:10.5152/balkanmedj.2015.15932

Cited by 5 publications

(1 citation statement)

References 22 publications

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“…It was also suggested from multiple sources that some antidepressants (citalopram, amitriptyline) may cause QRS/QT prolongation activating A 1 AdRs. Cardiovascular toxicity was reversed, when AdR antagonists were employed …”

Section: Organ‐specific Toxicity Of Adenosine Derivatives and Adenosimentioning

confidence: 99%

Safety issues of compounds acting on adenosinergic signalling

Schmidt

Ferk

2017

Journal of Pharmacy and Pharmacology

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Objectives Much research has been performed on the field of identifying the roles of adenosine and adenosinergic signalling, but a relatively low number of marketing authorizations have been granted for adenosine receptor (AdR) ligands. In part, this could be related to their safety issues; therefore, our aim was to examine the toxicological and adverse effects data of different compounds acting on adenosinergic signalling, including different AdR ligands and compounds resembling the structure of adenosine. We also wanted to present recent pharmaceutical developments of experimental compounds that showed promising results in clinical trial setting. Key findings Safety issues of compounds modulating adenosinergic signalling were investigated, and different mechanisms were presented. Structurally different classes of compounds act on AdRs, the most important being adenosine, adenosine derivatives and other non-nucleoside compounds. Many of them are either not selective enough or are targeting other targets of adenosinergic signalling such as metabolizing enzymes that regulate adenosine levels. Many other targets are also involved that are not part of adenosinergic signalling system such as GABA receptors, different channels, enzymes and others. Some synthetic AdR ligands even showed to be genotoxic. Summary Current review presents safety data of adenosine, adenosine derivatives and other non-nucleoside compounds that modulate adenosinergic signalling. We have presented different mechanisms that participate to an adverse effect or toxic outcome. A separate section also deals with possible organ-specific toxic effects on different in-vitro and in-vivo models.

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Section: Organ‐specific Toxicity Of Adenosine Derivatives and Adenosimentioning

confidence: 99%