The Effects of the Carbonic Anhydrase Inhibitor “6063” on Electrolytes and Acid-Base Balance in Two Normal Subjects and Two Patients With Respiratory Acidosis 1

Nadell, Judith; Kalinsky, Helen

doi:10.1172/jci102773

Cited by 74 publications

(12 citation statements)

References 14 publications

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“…Normal subjects sometimes develop drowsiness and paresthesias after receiving doses of the drug exceeding 1 g (47)(48)(49), and such a response was observed to begin about 2 hours after infusion in one of our controls. This response, whose mechanism is unknown, was qualitatively entirely different from the increased confusion and mental obtundity found in the cirrhotics, and the time -delay was also dissimilar to the cirrhotics' immediate worsening.…”

Section: Normal Valuesmentioning

confidence: 70%

The Toxic Effects of Carbon Dioxide and Acetazolamide in Hepatic Encephalopathy *

Posner¹,

Plum²

1960

J. Clin. Invest.

173

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Section: Normal Valuesmentioning

confidence: 70%

The Toxic Effects of Carbon Dioxide and Acetazolamide in Hepatic Encephalopathy *

Posner¹,

Plum²

1960

J. Clin. Invest.

173

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“…Acetazolamide [44][45][46][47] causes a bicarbonate diuresis, resulting in a m etabolic acidosis, th ereb y correcting the m etabolic alkalosis. I t causes potassium -loss in th e urine.…”

Section: Post-hypercapneic Hypotensionmentioning

confidence: 99%

Conservative and Aggressive Treatment of Acute Severe Respiratory Insufficiency in Patients with Chronic Non-Specific Lung Disease (C.N.S.L.D.)

Sluiter¹,

Koolhaas²,

Lende³

et al. 1964

Respiration

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“…Acetazolamide also produces chronic hyperventilation in awake, normal subjects and in some patients with obstructive airway disease (6,7), and it has been shown that ACET reduces the frequency and magnitude of arterial oxygen desaturation during sleep at high altitude (4). These ventilatory responses to chronic carbonic anhydrase inhibition appear to be mediated exclusively by increased hydrogen ion concentration ([H + ]) acting at both peripheral and medullary chemoreceptor sites (8,9).…”

Section: Introductionmentioning

confidence: 99%

Relative Effectiveness of Acetazolamide versus Medroxyprogesterone Acetate in Correction of Chronic Carbon Dioxide Retention^{1 ,}²

Skatrud¹,

Dempsey²

1983

Am Rev Respir Dis

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We compared the relative efficacy of normalization of plasma bicarbonate with acetazolamide (ACET) versus medroxyprogesterone acetate (MPA) in correcting chronic C02 retention during waking and sleeping states in patients with chronic obstructive airway disease (COPD). During placebo period, inspiratory effort (P0 -,) was high but insufficient to raise minute ventilation (VE) to the supernormal levels required for sufficient alveolar ventilation to normalize Paco2-Chronic ventilatory stimulation with either drug increased P0.i (5 to 42%), mean inspiratory flow (14 to 31%), tidal volume (11 to 22%), and VE (16 to 19%) in 11 of 15 patients. This resulted in significant correction of their C02 retention during waking and sleeping states (APaco2 = -5 to -16 mmHg), despite the presence of high inspiratory impedance, shortened inspiratory time, and nonuniform ventilation-perfusion ratio. The acute ventilatory response to exogenous C02 was not a good predictor of the chronic ventilatory response to MPA or even of the chronic response mediated by the ACET-induced increase in hydrogen ion concentration ([H]). In 5 patients, ACET therapy was ineffective in correcting Paco2 despite increasing [H + ] in plasma andcerebrospinal fluid (CSF). However, these same patients did correct Paco2 with MPA coincident with an alkaline shift in plasma and CSF. The data confirm, using two means of chronic pharmacologic ventilatory stimulation, that insufficient inspiratory effort, as well as an abnormal breathing pattern, is a critical determinant of chronic C02 retention. They further show that ACETinduced acidification of plasma and cerebrospinal fluid does not cause sustained augmentation of ventilatory drive in a significant number of patients with COPD and chronic C02 retention.

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The Effects of the Carbonic Anhydrase Inhibitor “6063” on Electrolytes and Acid-Base Balance in Two Normal Subjects and Two Patients With Respiratory Acidosis 1

Cited by 74 publications

References 14 publications

The Toxic Effects of Carbon Dioxide and Acetazolamide in Hepatic Encephalopathy *

The Toxic Effects of Carbon Dioxide and Acetazolamide in Hepatic Encephalopathy *

Conservative and Aggressive Treatment of Acute Severe Respiratory Insufficiency in Patients with Chronic Non-Specific Lung Disease (C.N.S.L.D.)

Relative Effectiveness of Acetazolamide versus Medroxyprogesterone Acetate in Correction of Chronic Carbon Dioxide Retention^{1 ,}²

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The Effects of the Carbonic Anhydrase Inhibitor “6063” on Electrolytes and Acid-Base Balance in Two Normal Subjects and Two Patients With Respiratory Acidosis 1

Cited by 74 publications

References 14 publications

The Toxic Effects of Carbon Dioxide and Acetazolamide in Hepatic Encephalopathy *

The Toxic Effects of Carbon Dioxide and Acetazolamide in Hepatic Encephalopathy *

Conservative and Aggressive Treatment of Acute Severe Respiratory Insufficiency in Patients with Chronic Non-Specific Lung Disease (C.N.S.L.D.)

Relative Effectiveness of Acetazolamide versus Medroxyprogesterone Acetate in Correction of Chronic Carbon Dioxide Retention1 ,2

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Relative Effectiveness of Acetazolamide versus Medroxyprogesterone Acetate in Correction of Chronic Carbon Dioxide Retention^{1 ,}²