The effects of the nitric oxide synthase inhibitors on the behaviour of small-platform-stressed mice in the plus-maze test

Pokk, Paavo; Väli, Marika

doi:10.1016/s0278-5846(01)00261-5

Cited by 31 publications

(32 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…L-NOARG also reverses anxiolysis associated with benzodiazepines [36] and nitrous oxide (N 2 O) [4] suggesting that NO is anxiolytic. In contrast to these results, administration of L-NAME, L-NOARG, or 7-nitroinazole (7-NI) decreases anxiety-like responses in the elevated plus-maze [9][10][11]15,35,45]. The nonselective properties of L-NAME and L-NOARG may be an important contributing factor in the disparate results that have been reported across studies, as these drugs influence both neuronal and endothelial NOS [47].…”

Section: Introductionmentioning

confidence: 91%

“…The biological substrates of social interactions, anxiety, and their interaction remain unclear. One chemical system that may be of interest is nitric oxide (NO) because inhibition of neuronal nitric oxide alters social [13,29] and anxiety-like behaviours [9,11,35,45].…”

Section: Introductionmentioning

confidence: 99%

“…Pharmacological inhibition of NO by administration of either NG-nitro-L-arginine methyl ester (L-NAME) or NG-nitro-l-arginine (L-NOARG), two nonspecific NOS inhibitors, increases anxiety-like responses [7,8,26,35,42]. L-NOARG also reverses anxiolysis associated with benzodiazepines [36] and nitrous oxide (N 2 O) [4] suggesting that NO is anxiolytic.…”

Section: Introductionmentioning

confidence: 99%

“…The nonselective properties of L-NAME and L-NOARG may be an important contributing factor in the disparate results that have been reported across studies, as these drugs influence both neuronal and endothelial NOS [47]. Furthermore, these drugs may increase anxiety-like responses through nonspecific changes such as vasoconstriction or reduced locomotor activity [7,35]. However, studies using the nNOS inhibitor 7-NI report decreases in anxiety-like responses [9,11,35,45].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, these drugs may increase anxiety-like responses through nonspecific changes such as vasoconstriction or reduced locomotor activity [7,35]. However, studies using the nNOS inhibitor 7-NI report decreases in anxiety-like responses [9,11,35,45].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Inhibition of neuronal nitric oxide reduces anxiety-like responses to pair housing

Workman¹,

Trainor²,

Finy³

et al. 2008

Behavioural Brain Research

View full text Add to dashboard Cite

Many psychological disorders are characterized by anxiety and alterations in social interactions. Recent studies demonstrate that the chemical messenger nitric oxide (NO) can regulate both anxiety and social behaviours. We tested whether an enzyme that produces NO in the brain, neuronal nitric oxide synthase (nNOS), serves as an interface between social interactions and anxiety-like behaviour. Several investigators have observed that mice increase anxiety-like responses in the elevated plusmaze after pair housing. nNOS gene deletion and 3-Bromo-7-Nitroindazole were used to inhibit the production of neuronal NO. Similar to previous studies, pair housing reduced open arm exploration in the elevated plus-maze. Pair housing also increased corticotropin-releasing hormone (CRH) immunoreactive cells in the paraventricular nucleus (PVN) of the hypothalamus. Inhibition of NO production increased open arm exploration in pair-housed mice but decreased open arm exploration in individually-housed mice. These results suggest that the effect of nNOS inhibition on anxiety-like responses is context dependent and that behavioural responses to social housing are altered after nNOS inhibition. This research suggests that NO may play an important role in mediating the effect social interactions have on anxiety.

show abstract

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Inhibition of neuronal nitric oxide reduces anxiety-like responses to pair housing

Workman¹,

Trainor²,

Finy³

et al. 2008

Behavioural Brain Research

View full text Add to dashboard Cite

show abstract

Possible Involvement of Nitric Oxide Modulatory Mechanisms in the Neuroprotective Effect of Centella asiatica Against Sleep Deprivation Induced Anxiety Like Behaviour, Oxidative Damage and Neuroinflammation

Chanana

Kumar

2016

Phytotherapy Research

View full text Add to dashboard Cite

Sleep deprivation (SD) is an experience of inadequate or poor quality of sleep that may produce significant alterations in multiple neural systems. Centella asiatica (CA) is a psychoactive medicinal herb with immense therapeutic potential. The present study was designed to explore the possible nitric oxide (NO) modulatory mechanism in the neuroprotective effect of CA against SD induced anxiety like behaviour, oxidative damage and neuroinflammation. Male laca mice were sleep deprived for 72 h, and CA (150 and 300 mg/kg) was administered alone and in combination with NO modulators for 8 days, starting five days before 72-h SD exposure. Various behavioural (locomotor activity, elevated plus maze) and biochemical (lipid peroxidation, reduced glutathione, catalase, nitrite levels and superoxide dismutase activity), neuroinflammation marker (TNF-alpha) were assessed subsequently. CA (150 and 300 mg/kg) treatment for 8 days significantly improved locomotor activity, anti-anxiety like effect and attenuated oxidative damage and TNF α level as compared to sleep-deprived 72-h group. Also while the neuroprotective effect of CA was increased by NO antagonists, it was diminished by NO agonists. The present study suggests that NO modulatory mechanism could be involved in the protective effect of CA against SD-induced anxiety-like behaviour, oxidative damage and neuroinflammation in mice.

show abstract

Behavioural and expressional phenotyping of nitric oxide synthase-I knockdown animals

Wultsch

Chourbaji

Fritzen

et al.

Journal of Neural Transmission. Supplementa

View full text Add to dashboard Cite

The effects of the nitric oxide synthase inhibitors on the behaviour of small-platform-stressed mice in the plus-maze test

Cited by 31 publications

References 60 publications

Inhibition of neuronal nitric oxide reduces anxiety-like responses to pair housing

Inhibition of neuronal nitric oxide reduces anxiety-like responses to pair housing

Possible Involvement of Nitric Oxide Modulatory Mechanisms in the Neuroprotective Effect of Centella asiatica Against Sleep Deprivation Induced Anxiety Like Behaviour, Oxidative Damage and Neuroinflammation

Behavioural and expressional phenotyping of nitric oxide synthase-I knockdown animals

Contact Info

Product

Resources

About