The Effects of the Paleo Diet on Autoimmune Thyroid Disease: A Mixed Methods Review

Hollywood, Jasmine B; Hutchinson, D; Feehery-Alpuerto, N; Whitfield, M; Davis, K; Johnson, L M

doi:10.1080/27697061.2022.2159570

Cited by 3 publications

(2 citation statements)

References 52 publications

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“…A beneficial effect was also noted after the introduction of Nigella sativa to the diet with no such improvements observed in patients on the iodine-restricted diet [119]. Interestingly, a paleolithic diet seemed to have positive effect on clinical improvement, as it is a natural source of nutrients similar to supplements, improving the function of thyroid gland in HT and Graves' disease natural history [120]. In turn, meat consumption has been suggested to be associated with increased odds ratio of developing thyroid autoimmunity.…”

Section: Diet and Thyroiditismentioning

confidence: 99%

Autoimmunity, New Potential Biomarkers and the Thyroid Gland—The Perspective of Hashimoto’s Thyroiditis and Its Treatment

Tywanek,

Michalak,

Świrska

et al. 2024

IJMS

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Autoimmune thyroid disease (AITD) is the most common organic specific illness of the thyroid gland. It may manifest as the overproduction or the decline of thyroxine and triiodothyronine. Hyperthyroidism develops due to the overproduction of hormones as an answer to the presence of stimulatory antibodies against the TSH receptor. Hashimoto’s thyroiditis (HT) is generally characterized by the presence of thyroid peroxidase and thyroglobulin antibodies, with a concomitant infiltration of lymphocytes in the thyroid. Due to the progressive destruction of cells, AITD can lead to subclinical or overt hypothyroidism. Pathophysiology of AITD is extremely complicated and still not fully understood, with genetic, environmental and epigenetic factors involved in its development. Due to increasing incidence and social awareness of this pathology, there is an urgent need to expand the background concerning AITD. A growing body of evidence suggests possible ways of treatment apart from traditional approaches. Simultaneously, the role of potential new biomarkers in the diagnosis and monitoring of AITD has been highlighted recently, too. Therefore, we decided to review therapeutic trends in the course of AITD based on its pathophysiological mechanisms, mainly focusing on HT. Another aim was to summarize the state of knowledge regarding the role of new biomarkers in this condition.

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Section: Diet and Thyroiditismentioning

confidence: 99%

Autoimmunity, New Potential Biomarkers and the Thyroid Gland—The Perspective of Hashimoto’s Thyroiditis and Its Treatment

Tywanek,

Michalak,

Świrska

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Meanwhile, nutritional intervention with a paleolithic diet in patients with autoimmune thyroiditis has been reported to improve both TPOAb titers and thyroid hormone in Hashimoto's thyroiditis and Graves' disease [47]. The paleo diet provides a percentage of macronutrients with antioxidative effects reducing autoimmune thyroid antibodies: the diet is anticipated to be more effective when it is combined with exercise and mindfulness and excludes modern processed/junk foods.…”

Section: Nutrition and Hashimoto's Thyroiditismentioning

confidence: 99%

Nutrition and thyroid disease

Duntas

2023

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of review The aim of this review was to determine, based on the most recent findings, the involvement of trace elements and vitamins critical for thyroid function and combating thyroid disease. Recent findings Nutritional guidance is pivotal to reducing the risk of thyroid disease and to managing it when it arises, this meaning the prescription of diets rich in such micronutrients as iodine, selenium, iron, zinc, and vitamins B12, D3, and A. Most of the above micronutrients are good antioxidants, building up an anti-inflammatory profile, reducing thyroid autoantibodies and body fat, and improving thyroid function. Diets are increasingly being prescribed, especially for those suffering from Hashimoto's thyroiditis. Notable among prescribed diets is the Mediterranean diet. Rich in critical elements, it benefits patients at the immune endocrine and biomolecular levels. Summary Importantly, it is likely that widespread adherence to the Mediterranean diet, together with a reduction of meat consumption and potential elimination of gluten and lactose may improve inflammation and have an impact on public health while possibly diminishing thyroiditis symptoms. It is hoped that this review can direct policymakers towards undertaking cost-effective interventions to minimize deficiency of essential minerals and vitamins and thus protect both general and thyroid health.

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A novel meta learning based stacked approach for diagnosis of thyroid syndrome

Abbas,

Munir,

Raza

et al. 2024

PLoS ONE

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Thyroid syndrome, a complex endocrine disorder, involves the dysregulation of the thyroid gland, impacting vital physiological functions. Common causes include autoimmune disorders, iodine deficiency, and genetic predispositions. The effects of thyroid syndrome extend beyond the thyroid itself, affecting metabolism, energy levels, and overall well-being. Thyroid syndrome is associated with severe cases of thyroid dysfunction, highlighting the potentially life-threatening consequences of untreated or inadequately managed thyroid disorders. This research aims to propose an advanced meta-learning approach for the timely detection of Thyroid syndrome. We used a standard thyroid-balanced dataset containing 7,000 patient records to apply advanced machine-learning methods. We proposed a novel meta-learning model based on a unique stack of K-Neighbors (KN) and Random Forest (RF) models. Then, a meta-learning Logistic Regression (LR) model is built based on the collective experience of stacked models. For the first time, the novel proposed KRL (KN-RF-LR) method is employed for the effective diagnosis of Thyroid syndrome. Extensive research experiments illustrated that the novel proposed KRL outperformed state-of-the-art approaches, achieving an impressive performance accuracy of 98%. We vindicated the performance scores through k-fold cross-validation and enhanced performance using hyperparameter tuning. Our research revolutionized the timely detection of thyroid syndrome, contributing to the enhancement of human life by reducing thyroid mortality rates.

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The Effects of the Paleo Diet on Autoimmune Thyroid Disease: A Mixed Methods Review

Cited by 3 publications

References 52 publications

Autoimmunity, New Potential Biomarkers and the Thyroid Gland—The Perspective of Hashimoto’s Thyroiditis and Its Treatment

Autoimmunity, New Potential Biomarkers and the Thyroid Gland—The Perspective of Hashimoto’s Thyroiditis and Its Treatment

Nutrition and thyroid disease

A novel meta learning based stacked approach for diagnosis of thyroid syndrome

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