The effects of the pyrethroid insecticide, bifenthrin, on steroid hormone levels and gonadal development of steelhead (Oncorhynchus mykiss) under hypersaline conditions

Forsgren, Kristy L.; Riar, Navneet; Schlenk, Daniel

doi:10.1016/j.ygcen.2013.02.047

Cited by 43 publications

(36 citation statements)

References 20 publications

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“…Acclimation to saltwater did not affect concentrations in either strain. Other studies that separated male and female animals showed that bifenthrin reduced E2 in females (and oocyte development) after acclimation [34]. These results are consistent with studies in catfish (Heteropneustes fossilis), which reported a significant decrease in E2 and 11-KT levels after 45 d of exposure to 20 mg/ L cypermethrin [35].…”

Section: Discussionsupporting

confidence: 86%

Effects of salinity acclimation on the endocrine disruption and acute toxicity of bifenthrin in freshwater and euryhaline strains of Oncorhynchus mykiss

Riar

Crago

Maryoung

et al. 2013

Enviro Toxic and Chemistry

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The pyrethroid insecticide bifenthrin is frequently detected at ng/L concentrations in tributaries of the San Francisco Bay Delta. The estuary is also experiencing increasing salinity through climate change and water redirection. To evaluate the impacts of hypersaline conditions on bifenthrin toxicity in anadromous salmonids of the San Francisco Bay Delta (CA, USA), a 14-d laboratory exposure was performed using 2 strains of Oncorhynchus mykiss (rainbow trout and steelhead) acclimated to freshwater and to 8 g/L and 17 g/L salinity. The fish were then exposed to nominal concentrations of 0 μg/L, 0.1 μg/L, and 1.5 μg/L bifenthrin. Rainbow trout exhibited significant mortality following exposure to 1.5 μg/L (1.07 ± 0.35 μg/L measured) bifenthrin in freshwater. Elevated levels of Na+/K+ adenosine triphosphatase α1A mRNA subunit expression was observed in the gill of rainbow trout acclimated to hypersaline conditions relative to freshwater animals. No significant difference was noted in Na+/K+ adenosine triphosphatase subunit levels in brains of either strain in freshwater or hypersaline conditions. Likewise, significant differences were not observed in plasma vitellogenin or steroid hormone concentrations in either strain whether maintained in freshwater or saltwater. Saltwater acclimation significantly reduced nicotinamide adenine dinucleotide phosphate–catalyzed biotransformation of bifenthrin in liver microsomes of rainbow trout but not of steelhead. The present study showed that, relative to steelhead, rainbow trout have different responses to bifenthrin acute toxicity as well as different rates of hepatic bifenthrin biotransformation and regulation of Na+/K+ adenosine triphosphatase subunits in gills. These data indicate that significant differences exist between the strains and that animal life history may have important effects on the susceptibility of each strain to environmental contaminants.

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Section: Discussionsupporting

confidence: 86%

Effects of salinity acclimation on the endocrine disruption and acute toxicity of bifenthrin in freshwater and euryhaline strains of Oncorhynchus mykiss

Riar

Crago

Maryoung

et al. 2013

Enviro Toxic and Chemistry

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“…Bifenthrin increased estrogen associated choriogenin and VTG plasma protein in Menidia beryllina as well as plasma estradiol-17b (E2) at 0.1 and 1.5 lg/L in juvenile RT (Brander et al 2012;Forsgren et al 2013). It also increased VTG in larval (0.07 lg L -1 ) and adult (0.140 lg L -1 ) FHM (Beggel et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Exploring the Impacts of Two Separate Mixtures of Pesticide and Surfactants on Estrogenic Activity in Male Fathead Minnows and Rainbow Trout

Crago

Tran

Budicin

et al. 2014

Arch Environ Contam Toxicol

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In this study, male fathead minnows (FHM) (Pimephales promelas) and juvenile rainbow trout (RT; Oncorhynchus mykiss) were exposed to two different surfactant mixtures of analytical-grade nonlyphenol, 4-tert octyphenol, octylphenol ethoxylates, nonylphenol ethoxylates, and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). After a 7-days exposure to environmentally relevant concentrations of these compounds, there was no difference in the relative mRNA expression of vitellogenin (VTG) in male juvenile RT exposed to individual compounds or the 2,4-D-surfactant mixture compared with the control. In male FHM, there was a significant increase in VTG mRNA expression in the high individual treatments of 2,4-D and the surfactants but not the 2,4-D-surfactant mixtures compared with the control. These results were compared with another study exposing male FHM to individual and a mixture of alkylphenols and alkylphenol ethoxylates in two different combinations with the herbicide diuron and the insecticide bifenthrin. There were no differences in the relative expression of VTG mRNA amongst individual exposures and the control. Interestingly, when the ethoxylate mixture was combined with diuron, there was a significant decrease in the relative mRNA expression of VTG compared with the control. However, when the ethoxylate mixture was combined with both diuron and bifenthrin, there was a significant increase in the relative mRNA expression of VTG in male compared with all other groups in the multichemical mixture. The results of this study highlight differences between species and measurements of VTG in assessing the risk of mixtures to aquatic organisms.

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“…A significant increase was observed in plasma estradiol of steelhead trout exposed to high bifenthrin concentrations (608 ± 182 ng/L). In male steelhead exposed to 28 ± 6 ng/L for 2 wk, a significant decrease in gonadal somatic indices was observed, whereas a significant increase in follicle diameter was noted in females . Although treatment with 1 ng/L (nominal) of bifenthrin failed to induce Vtg in Japanese medaka, combinations of 1 ng/L bifenthrin with diuron, 4‐nonylphenol, 4‐octylphenol, and the corresponding 1‐carbon ethoxylates of the alkylphenols led to a significant induction of estrogenic activity .…”

Section: Resultsmentioning

confidence: 95%

Effects of pyrethroid insecticides in urban runoff on Chinook salmon, steelhead trout, and their invertebrate prey

Weston

Schlenk

Riar

et al. 2015

Enviro Toxic and Chemistry

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Pyrethroid insecticides can affect salmonids either indirectly through toxicity to their prey or directly by toxicity to the fish themselves. In support of a study on pyrethroid impacts to Chinook salmon and steelhead trout in the American River (Sacramento, California, USA), 96-h median effective concentration (EC50) and median lethal concentration (LC50) values for the pyrethroid bifenthrin were determined for taxa not traditionally used for toxicity testing but of interest as salmonid prey, including a chironomid, caddisflies, mayflies, and stoneflies. A laboratory was constructed on the banks of the American River to expose macroinvertebrates, Chinook salmon, and steelhead trout to flow-through river water containing urban runoff during storm events. Bifenthrin from urban runoff was found in river water following 5 rain events, reaching 14.6 ng/L. Mortality to the exposed salmonids was not observed, and sublethal effects were not seen in vitellogenin or sex steroid levels. Indirect effects via toxicity to salmonid prey are possible. Mortality to Hyalella azteca, a potential prey, was observed in every event tested, and peak bifenthrin concentrations were comparable to the 96-h EC50 of the caddisfly, Hydropsyche sp., the most important prey species on a biomass basis for American River Chinook salmon. The other invertebrates tested had EC50s exceeding bifenthrin concentrations seen in the American River, though could potentially be at risk at concentrations previously reported in smaller urban tributaries. Environ Toxicol Chem 2015;34:649-657. © 2014 SETAC.

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The effects of the pyrethroid insecticide, bifenthrin, on steroid hormone levels and gonadal development of steelhead (Oncorhynchus mykiss) under hypersaline conditions

Cited by 43 publications

References 20 publications

Effects of salinity acclimation on the endocrine disruption and acute toxicity of bifenthrin in freshwater and euryhaline strains of Oncorhynchus mykiss

Effects of salinity acclimation on the endocrine disruption and acute toxicity of bifenthrin in freshwater and euryhaline strains of Oncorhynchus mykiss

Exploring the Impacts of Two Separate Mixtures of Pesticide and Surfactants on Estrogenic Activity in Male Fathead Minnows and Rainbow Trout

Effects of pyrethroid insecticides in urban runoff on Chinook salmon, steelhead trout, and their invertebrate prey

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