The spur gear mechanism with the standard involute profile may generate noise and shock because of tooth structure and transmission principle, resulting in substantial transmission errors. These limitations can be effectively resolved through tooth profile modification. To address the defects and deficiencies of existing tooth profile modification methods in terms of the modification principle and effect assessment, this study proposes an adaptive method of tooth profile modification with alterable tooth profile for spur gear mechanism. A corresponding simulation method for evaluating the modification performance of the gear transmission was introduced in detail. The final shape parameters of the modification profile were determined by orthogonal experiments. Simulation results show that tooth profile modification for involute spur gear does not affect bending and contact stresses. The process can also effectively improve the stability of transmission. The impact and noise of gear pair with tooth profile modification significantly decreased during meshing. The proposed method exhibits stronger adaptability compared with other existing methods of tooth profile modification. Moreover, the proposed method can adaptively determine the optimal modification parameters based on different conditions and obtain the ideal modification effect.