The effects of theta-burst stimulation on sleep and vigilance in humans

Mensen, Armand; Gorban, Corina; Niklaus, Marcel; Kuske, Eva Anina; Khatami, Ramin

doi:10.3389/fnhum.2014.00420

Cited by 18 publications

(14 citation statements)

References 36 publications

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“…Transcranial magnetic stimulation was delivered via a figure of eight coil with a 70 mm diameter using a Magstim Super Rapid Stimulator (Magstim, United Kingdom) at 40% machine output. This intensity is in accordance with other cTBS studies ( Mochizuki et al, 2005 ; Koch et al, 2008 ; Nyffeler et al, 2008 , 2009 ; Mensen et al, 2014 ) and studies that have employed fixed intensities above 80% motor threshold when combining cTBS with fMRI ( Pitcher et al, 2014 , 2017 ).…”

Section: Methodssupporting

confidence: 90%

Investigating the Neural Basis of Theta Burst Stimulation to Premotor Cortex on Emotional Vocalization Perception: A Combined TMS-fMRI Study

Agnew

Banissy

McGettigan

et al. 2018

Front. Hum. Neurosci.

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Previous studies have established a role for premotor cortex in the processing of auditory emotional vocalizations. Inhibitory continuous theta burst transcranial magnetic stimulation (cTBS) applied to right premotor cortex selectively increases the reaction time to a same-different task, implying a causal role for right ventral premotor cortex (PMv) in the processing of emotional sounds. However, little is known about the functional networks to which PMv contribute across the cortical hemispheres. In light of these data, the present study aimed to investigate how and where in the brain cTBS affects activity during the processing of auditory emotional vocalizations. Using functional neuroimaging, we report that inhibitory cTBS applied to the right premotor cortex (compared to vertex control site) results in three distinct response profiles: following stimulation of PMv, widespread frontoparietal cortices, including a site close to the target site, and parahippocampal gyrus displayed an increase in activity, whereas the reverse response profile was apparent in a set of midline structures and right IFG. A third response profile was seen in left supramarginal gyrus in which activity was greater post-stimulation at both stimulation sites. Finally, whilst previous studies have shown a condition specific behavioral effect following cTBS to premotor cortex, we did not find a condition specific neural change in BOLD response. These data demonstrate a complex relationship between cTBS and activity in widespread neural networks and are discussed in relation to both emotional processing and the neural basis of cTBS.

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Section: Methodssupporting

confidence: 90%

Investigating the Neural Basis of Theta Burst Stimulation to Premotor Cortex on Emotional Vocalization Perception: A Combined TMS-fMRI Study

Agnew

Banissy

McGettigan

et al. 2018

Front. Hum. Neurosci.

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“…A recent study provides indications on effects of TMS on sleep and vigilance in humans. These effects depend on the protocols, design and models we used (Mensen et al, 2014). These studies highlight the therapeutic potential of the induction of TMS in O. degus.…”

Section: Discussionmentioning

confidence: 88%

Cognitive Impairment After Sleep Deprivation Rescued by Transcranial Magnetic Stimulation Application in Octodon degus

et al. 2015

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Sleep is indispensable for maintaining regular daily life activities and a fundamental physiological purpose in cognitive performance. Sleep deprivation (SD) may affect subsequent learning capacity and ability to constitute new memories, particularly in the situation of hippocampusdependent tasks. Transcranial magnetic stimulation (TMS) is a non-invasive procedure of electromagnetic induction that generates electric currents activating nearby nerve cells in the stimulated cortical area. Several studies have begun to therapeutically use TMS. The present study was designed to evaluate how TMS could improve learning and memory functions after SD in O. degus. Thirty juvenile (aged eighteen months old) females were divided in three groups (control, acute and chronic TMS treatment -with and without SD). To immobilize TMS-treated groups, they were disposed in plastic cylindrical while the O. degus were receiving head magnetic stimulation. SD was achieved by gently handling the animals to keep them awake during the night. Behavioral tests include Radial Arm Maze (RAM), Barnes Maze (BM) and Novel Object Recognition (NOR). When TMS treatment was applied during several days, there was significant improvement of cognitive performance after SD. Noteworthy, only one session of TMS is able to improve some parameters related with spatial memory. No side effects were observed. After SD, chronic TMS treatment provokes significant amelioration in learning and in both spatial and working memory. Nonetheless, an acute treatment of TMS is already sufficient to improve spatial memory. To our knowledge, in this manuscript we confirm that sleep deprivation (SD) results in cognitive impairment measured with 3 different psychological tests, and we provide the evidence that transcranial magnetic stimulation (TMS) treatment significantly improve cognitive performance in sleep-deprived animals. Then, after SD, TMS can improve learning, spatial memory and working memory functions.We feel that these exciting results are novel and important, and can be of interest for scientists, neurologists and physicians working on sleep pathologies.The experimental work was done in compliance with the National Research Council's Guide for the care and use of laboratory animals, and the Guidelines promulgated by the European Communities Council Directive 2010/63/ECC.The data presented in the manuscript are original and the manuscript is not under consideration elsewhere. None of the manuscript contents has been previously published. In the present work we do not have any conflict of financial interest.All authors have seen and approved the manuscript.Trusting you will consider our manuscript worthy of review by your Journal, Yours truly, there was significant improvement of cognitive performance after SD. María-Trinidad HerreroNoteworthy, only one session of TMS is able to improve some parameters related with spatial memory. No side effects were observed. After SD, chronic TMS treatment provokes significant amelioration in learning and in both spat...

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“…Stimulation of primary motor cortex and lateral (extrastriate) occipital cortex, both nodes in our network, has been associated with markers of impaired arousal. Stimulation of primary motor cortex induced delta waves on EEG, which are usually only seen in patients with impaired consciousness (Assenza, Pellegrino, Tombini, Di Pino, & Di Lazzaro, ), while stimulation of lateral occipital cortex, but not dorsolateral prefrontal cortex, showed effects on vigilance and arousal (Mensen, Gorban, Niklaus, Kuske, & Khatami, ).…”

Section: Discussionmentioning

confidence: 99%

Cortical lesions causing loss of consciousness are anticorrelated with the dorsal brainstem

Snider

Hsu

Darby

et al. 2020

Human Brain Mapping

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Brain lesions can provide unique insight into the neuroanatomical substrate of human consciousness. For example, brainstem lesions causing coma map to a specific region of the tegmentum. Whether specific lesion locations outside the brainstem are associated with loss of consciousness (LOC) remains unclear. Here, we investigate the topography of cortical lesions causing prolonged LOC (N = 16), transient LOC (N = 91), or no LOC (N = 64). Using standard voxel lesion symptom mapping, no focus of brain damage was associated with LOC. Next, we computed the network of brain regions functionally connected to each lesion location using a large normative connectome dataset (N = 1,000). This technique, termed lesion network mapping, can test whether lesions causing LOC map to a connected brain circuit rather than one brain region. Connectivity between cortical lesion locations and an a priori coma‐specific region of brainstem tegmentum was an independent predictor of LOC (B = 1.2, p = .004). Connectivity to the dorsal brainstem was the only predictor of LOC in a whole‐brain voxel‐wise analysis. This relationship was driven by anticorrelation (negative correlation) between lesion locations and the dorsal brainstem. The map of regions anticorrelated to the dorsal brainstem thus defines a distributed brain circuit that, when damaged, is most likely to cause LOC. This circuit showed a slight posterior predominance and had peaks in the bilateral claustrum. Our results suggest that cortical lesions causing LOC map to a connected brain circuit, linking cortical lesions that disrupt consciousness to brainstem sites that maintain arousal.

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The effects of theta-burst stimulation on sleep and vigilance in humans

Cited by 18 publications

References 36 publications

Investigating the Neural Basis of Theta Burst Stimulation to Premotor Cortex on Emotional Vocalization Perception: A Combined TMS-fMRI Study

Investigating the Neural Basis of Theta Burst Stimulation to Premotor Cortex on Emotional Vocalization Perception: A Combined TMS-fMRI Study

Cognitive Impairment After Sleep Deprivation Rescued by Transcranial Magnetic Stimulation Application in Octodon degus

Cortical lesions causing loss of consciousness are anticorrelated with the dorsal brainstem

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