The effects of three different prokinetic drugs on the motility hormones level in lambs with postoperative ileus

Abstract

The aim of this study was to evaluate the effects of the three different prokinetic agents, namely erythromycin, lidocaine, and metoclopramide in lambs with postoperative ileus (POI) using motilin and ghrelin, which are known as motility markers. Twenty lambs were allocated to 4 groups of 5 lambs each. An enterotomy was performed on the ileum of each lamb. Erythromycin (8.8 mg/ kg), metoclopramide (0.2 mg/kg), and saline (2 mL) were administered as single dose IM before surgery in the ERT, MET, and CNTR groups, respectively. Lidocaine was administered to the LID group, both as a bolus before (1.3 mg/kg IV) and as a continuous rate infusion during surgery (0.05 mg/kg/h IV). Serum motilin and ghrelin concentrations as motility hormones were measured with ELISA. The serum motilin concentration was significantly higher at 0, 1, 3, 5, 10, 24, and 48 h in the ERT group and at 1 and 10 h in the LID group. The serum ghrelin concentration was significantly higher at 0, 1, and 48 h in the ERT group and at 3, 5, 10, 24, and 48 h in the LID group. As a result, erythromycin and lidocaine was thought to be useful in lambs with POI according to the stimulatory effects on the motility hormones.

Retrospective study on the use of lidocaine constant rate infusions for the treatment of ileus in ruminants and camelids

“…In this case series, only 1 animal had clear evidence of enteritis, so this antimicrobial effect could have played a role in the positive outcome in this case 20,21 . An additional study observed the effect of different prokinetic agents on POI with motilin and ghrelin as motility markers 22 . They observed that the use of lidocaine resulted in significantly higher motilin concentrations, suggesting it might be useful for lambs with POI.…”

“… 20 , 21 An additional study observed the effect of different prokinetic agents on POI with motilin and ghrelin as motility markers. 22 They observed that the use of lidocaine resulted in significantly higher motilin concentrations, suggesting it might be useful for lambs with POI. Our study assessed the efficacy of this therapy by identifying evidence of improved intestinal motility in the medical record after initiation of the CRI.…”