The effects of thyroxine replacement on the levels of serum asymmetric dimethylarginine (ADMA) and other biochemical cardiovascular risk markers in patients with subclinical hypothyroidism

Özcan, Ömer; Çakır, Erdinç; Yaman, Halıl; Akgül, Emin Özgür; Ertürk, K.; Beyhan, Zeynel; Bilgi, Cumhur; Erbil, M.

doi:10.1111/j.1365-2265.2005.02326.x

Cited by 59 publications

(50 citation statements)

References 29 publications

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“…Total cholesterol and LDL-C were significantly higher in patients with SCH as compared with control subjects, however triglyceride and HDL-C were not statistically different. The same results were obtained by Ozcan et al 2005 who reported high total cholesterol and LDL-C in patients with SCH [14]. Interestingly, they found reduced sdLDL levels in SCH patients.…”

Section: Discussionsupporting

confidence: 76%

Subclinical Hypothyroidism Is Associated with Early Insulin Resistance in Kuwaiti Women

et al. 2006

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Abstract. Subclinical hypothyroidism (SH), defined as an asymptomatic state characterized by normal serum concentrations of free thyroxine and elevated serum concentrations of TSH. The aim of this study is to investigate the complex interplay between insulin resistance and low grade chronic inflammation in Kuwaiti women with subclinical hypothyroidism. Thirty four women with subclinical hypothyroidism (SH) and 20 healthy women as controls matched to the patient group for sex, age and body mass index (BMI), were enrolled in this prospective study. TSH, FT4, C reactive protein, glucose, insulin, Homeostasis Model assessment (HOMA), total cholesterol (TC), triglycerides (TG), lowdensity lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) were estimated. Total cholesterol and LDL-C were significantly higher in patients with SCH as compared with control subjects, however triglyceride and HDL-C were not statistically different. CRP was not statistically different between the SCH patients and control group (3.64 ± 0.94 Vs 3.18 ± 0.71 P>0.05). Insulin levels were significantly higher in the SCH group comparable to the control (12.5 ± 2.67 Vs 10.80 ± 2.01 p<0.05), however HOMA-IR was not statistically different (2.85 ± 0.64 Vs 2.54 ± 0.64 P>0.05). Patients with subclinical hypothyroidism exhibited elevated atherogenic parameters (hyperinsulinemia, total cholesterol, LDL-C). Therefore screening and treatment for subclinical hypothyroidism may be warranted due to its adverse effects on lipid metabolism.

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Section: Discussionsupporting

confidence: 76%

Subclinical Hypothyroidism Is Associated with Early Insulin Resistance in Kuwaiti Women

et al. 2006

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“…[40] Several investigators have proposed ADMA as a potentially useful biomarker in cardiovascular disease. Until recently, there was no compelling evidence that ADMA plays a causal role in the pathophysiology of vascular disease.…”

Section: Discussionmentioning

confidence: 99%

Relations between Concentrations of Asymmetric Dimethylarginine and Neopterin as Potential Risk Factors for Cardiovascular Diseases in Haemodialysis-Treated Patients

et al. 2008

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Objectives. To investigate the correlation between concentrations of asymmetric dimethylarginine (ADMA) and neopterin (NP) as potential risk factors for cardiovascular diseases in chronic renal failure patients. Method. In this study, 33 patients with renal failure before and after haemodialysis were compared with healthy control subjects. Serum ADMA and NP levels were measured using high performance liquid chromatography (HPLC). Results. When ADMA and NP concentrations in renal failure patients were compared before and after dialysis, before dialysis ADMA and NP concentrations were higher than those in the control group. However, ADMA and NP levels showed a falling mean and clear after dialysis. While there is no correlation between ADMA and NP levels before dialysis, there is a mean and positive correlation between ADMA and NP levels after dialysis. Conclusion. Potential risk factors for cardiovascular diseases include high concentrations of both ADMA and NP levels in chronic renal failure patients. A correlation mean between ADMA and NP levels after dialysis was found, but no correlation between ADMA and NP levels before haemodialysis was discovered. These can be evaluated as two different risk factors independent from each other.

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“…One study investigated overt hypothyroid patients [7] and found no significant discordance in percentages of B phenotype (that represents predominance of sdLDL) from the controls. Another study on subclinical hypothyroidism [8] observed a decreased level of sdLDL in spite of raised TC and LDL-C. These two studies however did not adjust for the major confounding expected from triglyceride levels and hence we can not be sure that they truly reflect a hypothyroid effect.…”

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confidence: 99%

Hypothyroidism Results in Small Dense LDL Independent of IRS Traits and Hypertriglyceridemia

et al. 2008

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Abstract. There is evidence of an association between hypothyroidism and coronary heart disease. We decided to look at the relationship between hypothyroidism and LDL subclasses' pattern including small, dense LDL to define a biochemical basis for better management of the CHD risk of these patients. We utilized a case-control design to evaluate differences in lipid parameters between cases and controls. Univariate analysis revealed that many factors were associated with LDL particle size. Binary logistic regression however revealed that only thyroid status and serum triglyceride (TG) levels were independently associated with LDL particle size. Results from this study support an independent association between LDL particle size phenotype and both plasma TG concentrations and thyroid status. After adjusting for TG levels, other insulin resistance syndrome (IRS) traits were not associated with LDL size phenotype, suggesting that the IRS related sdLDL is linked most strongly to alterations in TG levels.

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The effects of thyroxine replacement on the levels of serum asymmetric dimethylarginine (ADMA) and other biochemical cardiovascular risk markers in patients with subclinical hypothyroidism

Cited by 59 publications

References 29 publications

Subclinical Hypothyroidism Is Associated with Early Insulin Resistance in Kuwaiti Women

Subclinical Hypothyroidism Is Associated with Early Insulin Resistance in Kuwaiti Women

Relations between Concentrations of Asymmetric Dimethylarginine and Neopterin as Potential Risk Factors for Cardiovascular Diseases in Haemodialysis-Treated Patients

Hypothyroidism Results in Small Dense LDL Independent of IRS Traits and Hypertriglyceridemia

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