The effects of time of day-specific resistance training on adaptations in skeletal muscle hypertrophy and muscle strength: A systematic review and meta-analysis

Grgić, Jozo; Lazinica, Bruno; Garofolini, Alessandro; Schöenfeld, Brad J.; Saner, Nicholas J.; Mikulić, Pavle

doi:10.1080/07420528.2019.1567524

Cited by 51 publications

(42 citation statements)

References 37 publications

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“…The assessment and analysis of moderators may help provide a better understanding of the observed inter-individual variability regarding the effect of physical exercise (e.g., resistance training) on the brain and on cognitive functions and help to foster the optimization of physical exercise interventions [125]. Furthermore, chronobiological factors (such as circadian variability) should be considered since they affect muscular adaptions in response to resistance exercises [229][230][231][232] and affect cognitive performance [233][234][235]. However, hemodynamic responses are reported to be relatively unaffected by, for instance, circadian variability [236].…”

Section: Adas-cogmentioning

confidence: 99%

Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements – a systematic review

Herold

Törpel

Schega

et al. 2019

Eur Rev Aging Phys Act

201

152

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Background: During the aging process, physical capabilities (e.g., muscular strength) and cognitive functions (e.g., memory) gradually decrease. Regarding cognitive functions, substantial functional (e.g., compensatory brain activity) and structural changes (e.g., shrinking of the hippocampus) in the brain cause this decline. Notably, growing evidence points towards a relationship between cognition and measures of muscular strength and muscle mass. Based on this emerging evidence, resistance exercises and/or resistance training, which contributes to the preservation and augmentation of muscular strength and muscle mass, may trigger beneficial neurobiological processes and could be crucial for healthy aging that includes preservation of the brain and cognition. Compared with the multitude of studies that have investigated the influence of endurance exercises and/or endurance training on cognitive performance and brain structure, considerably less work has focused on the effects of resistance exercises and/or resistance training. While the available evidence regarding resistance exercise-induced changes in cognitive functions is pooled, the underlying neurobiological processes, such as functional and structural brain changes, have yet to be summarized. Hence, the purpose of this systematic review is to provide an overview of resistance exercise-induced functional and/or structural brain changes that are related to cognitive functions. Methods and results: A systematic literature search was conducted by two independent researchers across six electronic databases; 5957 records were returned, of which 18 were considered relevant and were analyzed. Short conclusion: Based on our analyses, resistance exercises and resistance training evoked substantial functional brain changes, especially in the frontal lobe, which were accompanied by improvements in executive functions. Furthermore, resistance training led to lower white matter atrophy and smaller white matter lesion volumes. However, based on the relatively small number of studies available, the findings should be interpreted cautiously. Hence, future studies are required to investigate the underlying neurobiological mechanisms and to verify whether the positive findings can be confirmed and transferred to other needy cohorts, such as older adults with dementia, sarcopenia and/or dynapenia.

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Section: Adas-cogmentioning

confidence: 99%

Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements – a systematic review

Herold

Törpel

Schega

et al. 2019

Eur Rev Aging Phys Act

201

152

View full text Add to dashboard Cite

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“…All participants attended four laboratory sessions. All trials were performed in the morning hours (between 7 am and noon), and at the same time of the day across the sessions for each participant, to ensure that the results were not affected by circadian variation [14]. The trials took place 4 to 7 days apart.…”

Section: Experimental Designmentioning

confidence: 99%

CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance

Grgić

Pickering

Bishop

et al. 2020

Journal of the International Society of Sports Nutrition

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Background: It has been suggested that polymorphisms within CYP1A2 impact inter-individual variation in the response to caffeine. The purpose of this study was to explore the acute effects of caffeine on resistance exercise, jumping, and sprinting performance in a sample of resistance-trained men, and to examine the influence of genetic variation of CYP1A2 (rs762551) on the individual variation in responses to caffeine ingestion.Methods: Twenty-two men were included as participants (AA homozygotes n = 13; C-allele carriers n = 9) and were tested after the ingestion of caffeine (3 mg/kg of body mass) and a placebo. Exercise performance was assessed with the following outcomes: (a) movement velocity and power output in the bench press exercise with loads of 25, 50, 75, and 90% of one-repetition maximum (1RM); (b) quality and quantity of performed repetitions in the bench press exercise performed to muscular failure with 85% 1RM; (c) vertical jump height in a countermovement jump test; and (d) power output in a Wingate test.Results: Compared to placebo, caffeine ingestion enhanced: (a) movement velocity and power output across all loads (effect size [ES]: 0.20-0.61; p < 0.05 for all); (b) the quality and quantity of performed repetitions with 85% of 1RM (ES: 0.27-0.85; p < 0.001 for all); (c) vertical jump height (ES: 0.15; p = 0.017); and (d) power output in the Wingate test (ES: 0.33-0.44; p < 0.05 for all). We did not find a significant genotype × caffeine interaction effect (pvalues ranged from 0.094 to 0.994) in any of the analyzed performance outcomes.Conclusions: Resistance-trained men may experience acute improvements in resistance exercise, jumping, and sprinting performance following the ingestion of caffeine. The comparisons of the effects of caffeine on exercise performance between individuals with the AA genotype and AC/CC genotypes found no significant differences.

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“…There is a potential effect of circadian rhythm on performance, with some studies demonstrating that performance in a given task is better in the afternoon compared to the early morning [ 74 – 76 ]. Specifically, muscular abilities, such as strength, appear to peak in the evening hours [ 77 ]. For example, Guette et al [ 78 ] reported significantly lower maximal torque production at 06:00 and 10:00 h (~ 90% of maximum values) compared to strength performance at 18:00 h (~ 99% of maximal values).…”

Section: What Else Do We Need To Know About Caffeine In Sport?mentioning

confidence: 99%

Caffeine and Exercise: What Next?

2019

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Caffeine is a widely utilized performance-enhancing supplement used by athletes and non-athletes alike. In recent years, a number of meta-analyses have demonstrated that caffeine’s ergogenic effects on exercise performance are well-established and well-replicated, appearing consistent across a broad range of exercise modalities. As such, it is clear that caffeine is an ergogenic aid—but can we further explore the context of this ergogenic aid in order to better inform practice? We propose that future research should aim to better understand the nuances of caffeine use within sport and exercise. Here, we propose a number of areas for exploration within future caffeine research. These include an understanding of the effects of training status, habitual caffeine use, time of day, age, and sex on caffeine ergogenicity, as well as further insight into the modifying effects of genotype. We also propose that a better understanding of the wider, non-direct effects of caffeine on exercise, such as how it modifies sleep, anxiety, and post-exercise recovery, will ensure athletes can maximize the performance benefits of caffeine supplementation during both training and competition. Whilst not exhaustive, we hope that the questions provided within this manuscript will prompt researchers to explore areas with the potential to have a large impact on caffeine use in the future.

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The effects of time of day-specific resistance training on adaptations in skeletal muscle hypertrophy and muscle strength: A systematic review and meta-analysis

Cited by 51 publications

References 37 publications

Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements – a systematic review

Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements – a systematic review

CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance

Caffeine and Exercise: What Next?

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