The effects of time-restricted eating versus habitual diet on inflammatory cytokines and adipokines in the general adult population: a systematic review with meta-analysis

Turner, Laurent; Charrouf, Rasha; Martínez-Vizcaíno, Vicente; Hutchison, Amy; Heilbronn, Leonie K.; Fernández-Rodríguez, Rubén

doi:10.1016/j.ajcnut.2023.10.009

Cited by 11 publications

(4 citation statements)

References 70 publications

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“…For instance, TRE interventions could result in detrimental or neutral effects on bone health due to weight loss [ 18 ], changes in body composition [ 59 ], endocrine profile or hormonal concentrations, and some lifestyle behaviors [ 31 , 54 , 60 ]. Conversely, TRE could be related to positive changes in the gut microbiome, inflammatory biomarkers, and oxidative stress that may positively impact bone health [ 61 , 62 ]. Moreover, the realignment with the circadian rhythm might positively affect bone metabolism [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Time-Restricted Eating and Bone Health: A Systematic Review with Meta-Analysis

Fernández-Rodríguez,

Garrido-Miguel,

Bizzozero-Peroni

et al. 2024

Nutrients

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Time-restricted eating (TRE) has emerged as a dietary strategy that restricts food consumption to a specific time window and is commonly applied to facilitate weight loss. The benefits of TRE on adipose tissue have been evidenced in human trials and animal models; however, its impact on bone tissue remains unclear. To systematically synthesize and examine the evidence on the impact of TRE on bone health (bone mineral content (BMC), bone mineral density (BMD), and bone turnover factors), PubMed, Scopus, Cochrane CENTRAL, and Web of Science databases were systematically explored from inception to 1 October 2023 searching for randomized controlled trials (RCTs) aimed at determining the effects of TRE on bone health in adults (≥18 years). The Cochrane Handbook and the PRISMA recommendations were followed. A total of seven RCTs involving 313 participants (19 to 68 years) were included, with an average length of 10.5 weeks (range: 4 to 24 weeks). Despite the significant weight loss reported in five out of seven studies when compared to the control, our meta-analysis showed no significant difference in BMD (g/cm2) between groups (MD = −0.009, 95% CI: −0.026 to 0.009, p = 0.328; I2 = 0%). BMC and bone turnover markers between TRE interventions and control conditions were not meta-analyzed because of scarcity of studies (less than five). Despite its short-term benefits on cardiometabolic health, TRE did not show detrimental effects on bone health outcomes compared to those in the control group. Nevertheless, caution should be taken when interpreting our results due to the scarcity of RCTs adequately powered to assess changes in bone outcomes.

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Section: Discussionmentioning

confidence: 99%

Time-Restricted Eating and Bone Health: A Systematic Review with Meta-Analysis

Fernández-Rodríguez,

Garrido-Miguel,

Bizzozero-Peroni

et al. 2024

Nutrients

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“… 88 , 89 IF has been shown to have anti-inflammatory effects, which may help mitigate insulin resistance and improve glycemic control in individuals with obesity. 90 It is important to note that these potential mechanisms are based on current scientific understanding and require further investigation to fully elucidate the underlying pathways.…”

Section: Discussionmentioning

confidence: 99%

Intermittent fasting and health outcomes: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials

Sun,

Yao,

Wang

et al. 2024

eClinicalMedicine

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“…Although the specific mechanisms governing the anti-inflammatory effect of TRF on cisplatin-induced AKI were not delineated in this investigation, TRF is recognized for its intrinsic anti-inflammatory properties. In a meta-analysis encompassing 25 human studies, TRF is proposed as an effective approach to diminish TNF-α and leptin levels in the general adult population [ 24 ]. Previous research, both in humans and animals, has demonstrated that TRF reduces inflammatory responses in chronic inflammatory conditions, including cardiovascular disease, diabetes mellitus, neurodegenerative disorders, and arthritis [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Time-restricted feeding protects against cisplatin-induced acute kidney injury in mice

Jang,

Kim,

Kim

et al. 2024

Kidney Res Clin Pract

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Background: Time-restricted feeding (TRF), devoid of calorie restriction, is acknowledged for promoting metabolic health and mitigating various chronic metabolic diseases. While TRF exhibits widespread benefits across multiple tissues, there is limited exploration into its impact on kidney function. In this study, our aim was to investigate the potential ameliorative effects of TRF on kidney damage in a mouse model of cisplatin-induced acute kidney injury (AKI). Methods: Cisplatin-induced AKI was induced through intraperitoneal injection of cisplatin into C57BL/6 male mice. Mice undergoing TRF were provided unrestricted access to standard chow daily but were confined to an 8-hour feeding window during the dark cycle for 2 weeks before cisplatin injection. The mice were categorized into four groups: control, TRF, cisplatin, and TRF + cisplatin. Results: The tubular damage score and serum creatinine levels were significantly lower in the TRF + cisplatin group compared to the cisplatin group. The TRF + cisplatin group exhibited reduced expression of phosphorylated nuclear factor kappa B, inflammatory cytokines, and F4/80-positive macrophages compared to the cisplatin group. Furthermore, oxidative stress markers for DNA, protein, and lipid were markedly decreased in the TRF + cisplatin group compared to the cisplatin group. TUNEL-positive tubular cells, cleaved caspase-3 expression, and the Bax/Bcl-2 ratio in the TRF + cisplatin group were lower than those in the cisplatin group. Conclusion: TRF, without calorie restriction, effectively mitigated kidney damage by suppressing inflammatory reactions, oxidative stress, and tubular apoptosis in a mouse model of cisplatin-induced AKI. TRF holds promise as a novel dietary intervention for preventing cisplatin-induced AKI.

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The effects of time-restricted eating versus habitual diet on inflammatory cytokines and adipokines in the general adult population: a systematic review with meta-analysis

Cited by 11 publications

References 70 publications

Time-Restricted Eating and Bone Health: A Systematic Review with Meta-Analysis

Time-Restricted Eating and Bone Health: A Systematic Review with Meta-Analysis

Intermittent fasting and health outcomes: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials

Time-restricted feeding protects against cisplatin-induced acute kidney injury in mice

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