The effects of tirofiban on peripheral markers of oxidative stress and endothelial dysfunction in patients with acute coronary syndromes

Iliodromitis, Efstathios K.; Andreadou, Ioanna; Markantonis-Kyroudis, Sophia; Mademli, Kalliopi; Kyrzopoulos, Stamatis; Γεωργιάδου, Παναγιώτα; Kremastinos, Dimitrios Th.

doi:10.1016/j.thromres.2006.02.002

Cited by 11 publications

(8 citation statements)

References 29 publications

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“…This suggests that augmented VCAM-1 expression may reflect inflammation and endothelial dysfunction and hence impairing the regulation of blood pressure. This is because a significant reduction in the cell adhesion molecules expression may indicate a better preservation of endothelial function [55]. Besides, we do believe that the increased VCAM-1 (that is inflammation) may play a role, at least in part, in causing adverse remodelling.…”

Section: Discussionmentioning

confidence: 99%

Involvement of Inflammation and Adverse Vascular Remodelling in the Blood Pressure Raising Effect of Repeatedly Heated Palm Oil in Rats

Kamisah

Othman

et al. 2012

International Journal of Vascular Medicine

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Oil thermoxidation during deep frying generates harmful oxidative free radicals that induce inflammation and increase the risk of hypertension. This study aimed to investigate the effect of repeatedly heated palm oil on blood pressure, aortic morphometry, and vascular cell adhesion molecule-1 (VCAM-1) expression in rats. Male Sprague-Dawley rats were divided into five groups: control, fresh palm oil (FPO), one-time-heated palm oil (1HPO), five-time-heated palm oil (5HPO), or ten-time-heated palm oil (10HPO). Feeding duration was six months. Blood pressure was measured at baseline and monthly using tail-cuff method. After six months, the rats were sacrificed and the aortic arches were dissected for morphometric and immunohistochemical analyses. FPO group showed significantly lower blood pressure than all other groups. Blood pressure was increased significantly in 5HPO and 10HPO groups. The aortae of 5HPO and 10HPO groups showed significantly increased thickness and area of intima-media, circumferential wall tension, and VCAM-1 than other groups. Elastic lamellae were disorganised and fragmented in 5HPO- and 10HPO-treated rats. VCAM-1 expression showed a significant positive correlation with blood pressure. In conclusion, prolonged consumption of repeatedly heated palm oil causes blood pressure elevation, adverse remodelling, and increased VCAM-1, which suggests a possible involvement of inflammation.

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Section: Discussionmentioning

confidence: 99%

Involvement of Inflammation and Adverse Vascular Remodelling in the Blood Pressure Raising Effect of Repeatedly Heated Palm Oil in Rats

Kamisah

Othman

et al. 2012

International Journal of Vascular Medicine

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“…[27] Tirofiban is a competitive inhibitor of GPIIb/IIIa receptors, [28] and it has been suggested that it has protective effects on the endothelium, acute coronary syndrome, and symptomatic coronary artery disease. [29,30] Warnholtz et al [31] reported improvement in the flow-mediated dilation of the brachial artery after PCI with tirofiban treatment. However, these studies were all performed in clinical settings where there was obvious endothelial damage, and the vascular effects of tirofiban on an intact endothelium is uncertain.…”

Section: Discussionmentioning

confidence: 99%

The effects of clopidogrel, acetyl salicylic acid and tirofiban on acetylcholine-induced dilation in rat thoracic aorta segments

Özkısacık¹,

Discigil²,

Kurtoğlu³

et al. 2012

Turk Gogus Kalp Dama

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Amaç: Bu çalışmada, asetilsalisilik asit (ASA), klopidogrel ve tirofiban gibi antitrombositer ajanların sıçan torasik aort segmentinde asetilkolin (ACh) ile uyarılan gevşeme yanıt-ları üzerine olan etkileri araştırıldı. Ça lış ma pla nı: Yirmi sekiz adet ağırlıkları 250-300 g arasında olan Wistar-albino türü yetişkin erkek sıçan çalışmaya alındı. Sıçanlar randomize olarak dört gruba ayrıldı: ASA grubu (n=7), klopidogrel grubu (n=7), tirofiban grubu (n=7) ve kontrol grubu (n=7). Deneyden 12 saat önce intraperitoneal (İP) ASA (1.5 mg/kg) veya klopidogrel (1 mg/kg) enjeksiyonları yapıldı. Tirofiban grubunda, 150 μgr/kg tirofiban İP deneyden 1 ve 12 saat önce olmak üzere, iki kez verildi. Kontrol grubundaki sıçanlara herhangi bir ilaç verilmedi. Sıçanlar dekapite edildikten sonra torasik aort segmentleri çıkartıldı ve oksijenize Krebs çözeltisi içinde organ banyosuna asıldı ve aort halkalarında asetilkolin ile uyarılan gevşeme yanıtının doza bağımlı değişimleri incelendi. Bul gu lar: Asetilkolinin en düşük molar konsantrasyonu (10-9) ile elde edilen gevşeme yanıtının ASA (%94.3±3.3) ve klopidogrel (%94.6±3.1) grubunda kontrol (%86.7±8.1) grubuna göre azalmış olduğu bulundu (p<0.05). Daha yük-sek asetilkolin konsantrasyonlarında ise, tüm gruplarda gevşeme yanıtlarının benzer olduğu gözlemlendi. So nuç: Asetilsalisilik asit ve klopidogrel tedavilerinin sonucunda endotel aracılı gevşeme yanıtında hafif bir gecikme ortaya çıkmış ve tirofibanın belirgin bir etkisi olmamıştır. Bu bulgular ASA ve klopidogrelin endotel aracılı vazodilatasyon üzerinde sınırlı bir etkisi olabileceğini düşündürmektedir.Anah tar söz cük ler: Asetilsalisilik asit; klopidogrel; endotel; tirofiban. Background:In this article, we aimed to investigate the effects of antithrombotic agents, including acetyl salicylic acid (ASA), clopidogrel, and tirofiban on the acetylcholine (ACh)-induced dilation responses in rat thoracic aorta segments. Methods: Twenty-eight Wistar albino male rats weighing between 250-300 g were included in the study. The rats were randomly divided into four groups: the ASA group (n=7), the clopidogrel group (n=7), the tirofiban group (n=7), and the control group (n=7). Intraperitoneal (IP) injection of ASA (1.5 mg/kg) or clopidogrel (1 mg/kg) was administered 12 hours before the experiment. In the tirofiban group, 150 μgr/kg tirofiban IP was given twice at one and 12 hours before the experiment. The rats in the control group did not receive any medication. After the rats were decapitated, the segments of the thoracic aorta were removed and suspended in an oxygenated Krebs solution in a tissue bath, and the dose dependency in the responses to the ACh-induced dilation in the aortic rings were studied. Results:The dilation responses of the aortic rings to ACh in the lowest molar concentration (10-9) were found to be reduced in the ASA (94.3%±3.3) and clopidogrel (94.6%±3.1) groups when compared with the control group (86.7%±8.1) (p<0.05). The responses to higher concentrations of ACh were observed to be similar in all of the groups....

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“…In ACS patients GP IIb-IIIa antagonists are administrated after distraction of the atherosclerotic plaque and in PCI treated patients (at least in those who undergo elective PCI) before the traumatic injury of the vessel caused by angioplasty procedure. However, contradictory to this hypothesis the third GP IIb-IIIa blocker tirofiban was reported to decrease the level of inflammatory markers in ACS [20][21][22] but not in patients undergoing elective PCI [19]. The clarification of this controversy needs further investigation and probably the direct comparison of the anti-inflammatory effects of different GP IIb-IIIa antagonists.…”

Section: Discussionmentioning

confidence: 99%

“…However, this antagonist did not affect CRP and IL6 plasma concentrations in patients with ACS [18]. Another GP IIb-IIIa antagonist, tirofiban, failed to decrease CRP, TNFa and IL6 in patients undergoing PCI [19] but suppress increase of CRP [20], IL6 [21] and soluble cell adhesion molecules [21,22] in patients with ACS. One more GP IIb-IIIa blocker, eptifibatide, was reported to decrease CRP and other inflammatory markers in coronary angioplasty [23,24], but these results were not confirmed by other authors [25].…”

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confidence: 99%

Eptifibatide does not suppress the increase of inflammatory markers in patients with non-ST-segment elevation acute coronary syndrome

Mazaev

Naimushin

Масенко

et al. 2007

J Thromb Thrombolysis

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The effects of tirofiban on peripheral markers of oxidative stress and endothelial dysfunction in patients with acute coronary syndromes

Cited by 11 publications

References 29 publications

Involvement of Inflammation and Adverse Vascular Remodelling in the Blood Pressure Raising Effect of Repeatedly Heated Palm Oil in Rats

Involvement of Inflammation and Adverse Vascular Remodelling in the Blood Pressure Raising Effect of Repeatedly Heated Palm Oil in Rats

The effects of clopidogrel, acetyl salicylic acid and tirofiban on acetylcholine-induced dilation in rat thoracic aorta segments

Eptifibatide does not suppress the increase of inflammatory markers in patients with non-ST-segment elevation acute coronary syndrome

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