The effects of tocilizumab on clinical and laboratory features of patients with severe COVID-19: a single-center experience

Ashimov, Zhamalbek I.; Kudaiberdiev, Taalaibek Z.; Abibillaev, Damirbek A.; Gaibyldaev, Zhanybek J.; Zaripov, Dolonbek E.; Akhmedova, Irina A.

doi:10.24969/hvt.2020.220

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…If we rely on baseline clinical data, such as progressive dyspnea, abnormal respiratory auscultative findings, no significant differences were noted. Classically, acute respiratory distress syndrome is one of the result of cytokine storm and the main cause of severe respiratory failure and increased mortality (21,22). Nevertheless, respiratory events were not differed in both groups.…”

Section: Discussionmentioning

confidence: 99%

Single-center adult cardiac surgery practice during the COVID-19 era

Tukusheva,

Kudaiberdiev,

Abibillaev

et al. 2023

HVT

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Objective: Like other activities, cardiac surgical practice was also affected by pandemics. During the COVID-19 outbreak, it was crucial distinguishing the preoperative data of COVID-19 positive candidates for open-heart surgery from COVID-19 negative counterparts, as well as the influence of positive viral markers on earlier postoperative results. Methods: We retrospectively analyzed 177 patients who were operated in the Research Institute of Heart Surgery and Organ Transplantation from September 2020 to December 2021. Patients were categorized according to COVID-19 positive (CP) and COVID-19 negative (CN) groups. Baseline clinical, laboratory, imaging markers and perioperative findings were compared. Some of the perioperative findings were considered outcome variables. Due to unequal distributions, nonparametric tests were used for statistical analysis. Continuous variables were represented by mean and standard deviations, whereas categorical ones were by absolute count and percentage.Results: No substantial differences were detected in this small comparison study. Baseline clinical, laboratory and echocardiographic findings revealed similar conditions in both groups. Only hemoglobin levels were found higher in CP group (142.8 (18.2) vs 137.7 (19.9), p=0.03). The mostly performed operation was CABG-surgery in each group (22 vs 37 cases). There were no differences in intraoperative variables. Most of the patients of CN group presented by exacerbated heart failure signs in earlier postoperative period. Single mortality case was observed in CN group. Conclusion:In our cohort of patients, clinical, laboratory, imaging and perioperative parameters were not differed significantly in CP and CN groups altogether with some exceptions. Cardiac surgery was found as the relatively safe procedure during pandemics era. Congestive heart failure was the main event in the earlier post-op period.

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Section: Discussionmentioning

confidence: 99%

Single-center adult cardiac surgery practice during the COVID-19 era

Tukusheva,

Kudaiberdiev,

Abibillaev

et al. 2023

HVT

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The prevalence and course of COVID-19 and the Cardiovascular Diseases

Chan¹,

Assaf²,

Guella³

et al. 2022

HVT

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Corona pandemic has infected over 277 million people and has claimed more than 5.4 million lives with recovery of 249 million globally by early 2022. The global case fatality rate ranged from 6-7% in United States, Switzerland, Ireland, 12-14% in Sweden, Spain, Netherlands, United Kingdom, Italy, and 15-16% in France and Belgium among hospitalized and non-hospitalized COVID-19 patients, the prevalence of underlying cardiovascular diseases was 9%. The prevalence of cardiovascular diseases among hospitalized COVID-19 patients and those requiring intensive care unit admission were 23% and 29% respectively. The virus continues to evolve into new formats latest being Delta and Omicron variants. In a multicenter study of 8910 COVID-19 patients from 169 hospitals in Asia, Europe and North America, presence of pre-existing coronary artery disease, chronic heart failure and cardiac arrhythmia was associated with increased mortality of 10.2%, 15.3% and 11.5% respectively, compared with 5-6% mortality in those without the above co-morbidities. The systemic inflammation caused by SARS-CoV-2 could lead to a wide spectrum of cardiovascular complications including acute cardiac injury, acute coronary syndrome, coronary artery dissection, acute myocarditis, cardiomyopathy, chronic heart failure, cardiac arrhythmia, pulmonary embolism, cardiogenic shock, circulatory failure or even cardiac arrest.

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The effects of tocilizumab on clinical and laboratory features of patients with severe COVID-19: a single-center experience

Cited by 2 publications

References 16 publications

Single-center adult cardiac surgery practice during the COVID-19 era

Single-center adult cardiac surgery practice during the COVID-19 era

The prevalence and course of COVID-19 and the Cardiovascular Diseases

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