The effects of tocotrienol supplementation on lipid profile: A meta-analysis of randomized controlled trials

Zuo, Shuping; Wang, Guiping; Han, Quanle; Xiao, Hongling; Santos, Heitor O.; Rodríguez, David Avelar; Khani, Vahid; Tang, Jianlei

doi:10.1016/j.ctim.2020.102450

Cited by 18 publications

(9 citation statements)

References 55 publications

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“…Given that these guidelines recommend a pragmatic and individualized approach and do not advocate any specific diet for the treatment of NAFLD, our findings are noteworthy as a means of expanding the effect of IF regimens as one of many dietary strategies that can be employed through a personalized perspective, but this does not imply that IF is the best dietary approach. Bearing in mind the importance of personalized dietary plans, the addition of functional foods and supplements could also enhance the effect of IF or other dietary patterns in the management of liver parameters and cardiometabolic markers (64)(65)(66)(67)(68)(69)(70).…”

Section: Discussionmentioning

confidence: 99%

Effects of the 5:2 intermittent fasting diet on non-alcoholic fatty liver disease: A randomized controlled trial

et al. 2022

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Background and aimsDietary regimens are crucial in the management of non-alcoholic fatty liver disease (NAFLD). The effects of intermittent fasting (IF) have gained attention in this regard, but further research is warranted. Thus, we aimed to ascertain the overall effects of the 5:2 IF diet (5 days a week of normal food intake and 2 consecutive fasting days) in patients with NAFLD compared to a control group (usual diet).Methods and resultsA 12-week randomized controlled trial was performed to evaluate the effects of the 5:2 IF diet on anthropometric indices, body composition, liver indices, serum lipids, glucose metabolism, and inflammatory markers in patients with NAFLD. The IF group (n = 21) decreased body weight (86.65 ± 12.57–82.94 ± 11.60 kg), body mass index (30.42 ± 2.27–29.13 ± 1.95 kg/m2), waist circumference (103.52 ± 6.42–100.52 ± 5.64 cm), fat mass (26.64 ± 5.43–23.85 ± 5.85 kg), fibrosis (6.97 ± 1.94–5.58 ± 1.07 kPa), steatosis scores/CAP (313.09 ± 25.45–289.95 ± 22.36 dB/m), alanine aminotransferase (41.42 ± 20.98–28.38 ± 15.21 U/L), aspartate aminotransferase (34.19 ± 10.88–25.95 ± 7.26 U/L), triglycerides (171.23 ± 39.88–128.04 ± 34.88 mg/dl), high-sensitivity C-reactive protein (2.95 ± 0.62 −2.40 ± 0.64 mg/L), and cytokeratin-18 (1.32 ± 0.06–1.19 ± 0.05 ng/ml) values compared to the baseline and the end of the control group (n = 23)—p ≤ 0.05 were considered as significant. However, the intervention did not change the levels of high-density lipoprotein cholesterol, total cholesterol, low-density lipoprotein cholesterol, fasting blood sugar, insulin, HOMA-IR, and total antioxidant capacity.ConclusionAdhering to the 5:2 IF diet can reduce weight loss and related parameters (fat mass and anthropometric indicators of obesity), as well as hepatic steatosis, liver enzymes, triglycerides, and inflammatory biomarkers in patients with NAFLD.

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Section: Discussionmentioning

confidence: 99%

Effects of the 5:2 intermittent fasting diet on non-alcoholic fatty liver disease: A randomized controlled trial

et al. 2022

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“…But a nonsignificant effect was observed on total cholesterol and LDL levels. This meta‐analysis included different diseases including T2DM, heterogeneity of diseases can be a reason for the nonsignificant effect of T3 (Zuo et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Effects of delta‐tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial

Mahjabeen

Khan

Mirza

et al. 2021

Phytotherapy Research

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The study aimed to ascertain the effects of delta-tocotrienol (δT3) supplementation on glycemic control, oxidative stress, inflammation and related micro-ribonucleic acid (miRNA) expression in patients with type 2 diabetes mellitus (T2DM). Total 110 patients of T2DM on oral hypoglycemic agents, were randomly divided into tocotrienol and placebo groups and given 250 mg δT3 or cellulose soft gel capsule once daily respectively for 24 weeks. Glycemic control, oxidative stress, inflammatory biomarkers, and miRNAs expression were measured in serum at baseline and end of the intervention by using standard laboratory methods. Compared to the placebo, δT3 supplementation resulted in a significant (p ≤ .05) reduction [mean difference (95% confidence interval)] in plasma glucose [−0.48 (−0.65, −0.30)], insulin [−1.19 (−1.51, −0.87)], homeostatic model assessment of insulin resistance [−0.67 (−0.86, −0.49)], glycosylated hemoglobin [−0.53 (−0.79, −0.28)], malondialdehyde [−0.34 (−0.45, −0.22)], high sensitive-Creactive protein[−0.35 (−0.54, −0.16)], tumor necrosis factor-alpha [−1.22 (−1.62, −0.83)], and interleukin-6[−2.30 (−2.91, −1.68)]. More than twofold downregulation in miRNA expression was observed in the δT3 group compared to the placebo. The study demonstrated that δT3 supplementation in addition to oral hypoglycemic agents, improved glycemic control, inflammation, oxidative stress, and miRNA expression in T2DM without any adverse effect. Thus, δT3 might be considered as an effective dietary supplement to prevent long-term diabetic complications.

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“…Although vitamin E is mainly known for its antioxidant function, there is growing evidence that vitamin E interacts with several regulatory proteins, thereby modulating signaling pathways as well as gene expression (reviewed by Rimbach et al in [ 187 , 188 , 189 ]). Clinical trials studying the pharmacological effects of high-dose vitamin E supplementation on diseases with inflammation as an underlying mechanism, such as atherosclerosis, diabetes, and cancer, have not been convincing, since some trials produced results suggesting that vitamin E has no pharmacological benefit on health or may even increase the risk for chronic diseases and mortality [ 33 , 41 , 188 , 190 , 191 , 192 , 193 ]. Such unexpected results indicate that there may be mechanisms underlying the biological activities as well as the metabolism of vitamin E, which are not fully understood yet.…”

Section: Biological Activities Of Long-chain Metabolites Of Vitamin Ementioning

confidence: 99%

Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients

et al. 2022

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A hundred years have passed since vitamin E was identified as an essential micronutrient for mammals. Since then, many biological functions of vitamin E have been unraveled in both cell and animal models, including antioxidant and anti-inflammatory properties, as well as regulatory activities on cell signaling and gene expression. However, the bioavailability and physiological functions of vitamin E have been considerably shown to depend on lifestyle, genetic factors, and individual health conditions. Another important facet that has been considered less so far is the endogenous interaction with other nutrients. Accumulating evidence indicates that the interaction between vitamin E and other nutrients, especially those that are enriched by supplementation in humans, may explain at least some of the discrepancies observed in clinical trials. Meanwhile, increasing evidence suggests that the different forms of vitamin E metabolites and derivates also exhibit physiological activities, which are more potent and mediated via different pathways compared to the respective vitamin E precursors. In this review, possible molecular mechanisms between vitamin E and other nutritional factors are discussed and their potential impact on physiological and pathophysiological processes is evaluated using published co-supplementation studies.

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The effects of tocotrienol supplementation on lipid profile: A meta-analysis of randomized controlled trials

Cited by 18 publications

References 55 publications

Effects of the 5:2 intermittent fasting diet on non-alcoholic fatty liver disease: A randomized controlled trial

Effects of the 5:2 intermittent fasting diet on non-alcoholic fatty liver disease: A randomized controlled trial

Effects of delta‐tocotrienol supplementation on Glycemic Control, oxidative stress, inflammatory biomarkers and miRNA expression in type 2 diabetes mellitus: A randomized control trial

Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients

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