The Effects of Topical Timolol and Latanoprost on Calculated Ocular Perfusion Pressure in Nonglaucomatous Volunteers

Kolli, Ajay; Toris, Carol B.; Reed, David; Gilbert, Jesse; Sit, Arthur J.; Gulati, Vikas; Kazemi, Arash; Fan, Shan; Musch, David C.; Moroi, Sayoko E.

doi:10.1089/jop.2021.0068

Cited by 4 publications

(7 citation statements)

References 55 publications

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“…The mean ocular perfusion pressure was significantly (p<0.05) increased with both the drugs with latanoprost showing a greater percentage increase as compared to timolol [3].…”

Section: Mean Ocular Perfusion Pressurementioning

confidence: 90%

“…Hence, its measurement is vital in the initial diagnosis and management of glaucoma. The other risk factors for its occurrence include older age, thinner cornea, lower corneal hysteresis, systemic hypotension, and low ocular perfusion pressure (OPP) [3].…”

Section: Introductionmentioning

confidence: 99%

“…OPP is directly proportional to BP, whereas it is inversely proportional to IOP [5]. Glaucoma, associated with increased IOP, causes a decrease in OPP, leading to ONH and retinal ganglion cell damage [3]. Ophthalmologists routinely evaluate only the IOP to screen and evaluate the patients for glaucoma of the patients without estimating OPP.…”

Section: Introductionmentioning

confidence: 99%

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An Evaluation of Efficacy of Commonly Used First Line Drugs in Terms of Intra Ocular Pressure, Ocular Perfusion Pressure, and Field of Vision in Patients of Primary Open Angle Glaucoma of North Karnataka

INGALE

Ijeri

2023

Asian J Pharm Clin Res

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Objective: The objective of the study was to measure the efficacy of commonly used timolol and latanoprost as first line drugs in terms of intra ocular pressure (IOP) and ocular perfusion pressure (OPP). Methods: This was an open-labeled, randomized, and prospective study conducted in the outpatient department of ophthalmology. Newly diagnosed patients were recruited into the study. A total of 60 patients were recruited into our study and were randomized in a 1:1 ratio into two groups of 30 each to receive either timolol 0.5% eye drops twice daily (Group 1) or latanoprost 0.005% eye drops once daily in the evening for a period of 6 weeks (n=30/group). A baseline general ophthalmic examination was done, and the patients were followed up at week 4 and week 6. Results: Latanoprost has a greater IOP lowering effect in patients with primary open angle glaucoma as compared to timolol and also concurrently increases Ocular perfusion pressure to a larger extent as compared to timolol. Conclusion: Latanoprost (left eye: 18.47 and right eye: 18.36) has a greater IOP lowering effect in patients with primary open angle glaucoma as compared to timolol (left eye: 20.4 and right eye: 20.7). Latanoprost (left eye: 57.13 and right eye: 57.20) also concurrently increases ocular perfusion pressure to a larger extent as compared to timolol (left eye: 54.15 and right eye: 55.33).

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“…The mean ocular perfusion pressure was significantly (p<0.05) increased with both the drugs with latanoprost showing a greater percentage increase as compared to timolol [3].…”

Section: Mean Ocular Perfusion Pressurementioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Evaluation of Efficacy of Commonly Used First Line Drugs in Terms of Intra Ocular Pressure, Ocular Perfusion Pressure, and Field of Vision in Patients of Primary Open Angle Glaucoma of North Karnataka

INGALE

Ijeri

2023

Asian J Pharm Clin Res

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“…The effect of timolol on OPP is not clear. Several studies have noted no change [116], an increase when calculated with diastolic blood pressure but reduced OPP when calculated with systolic blood pressure [114], or only a daytime increase in OPP without any change in nocturnal or 24-hour OPP [118]. Brimonidine 0.2% did not affect OPP in patients with normal tension glaucoma [119].…”

Section: Ocular Blood Flowmentioning

confidence: 92%

“…Bimatoprost increased OPP in open-angle glaucoma and ocular hypertension patients [91]. Latanoprost increased ocular perfusion pressure (OPP) in non-glaucomatous eyes [114]. In normaltension glaucoma (NTG) patients with mean baseline IOP in the low teens, latanoprost did not affect OPP [115] but increased in NTG patients with IOP in the upper teens [116].…”

Section: Ocular Blood Flowmentioning

confidence: 99%

An Update on Pharmacotherapy of Glaucoma

Virani¹,

Rewri²

2023

Preprint

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Progressive loss of retinal ganglionic cells (RGC) causes blindness in glaucoma. Elevated intraocular pressure (IOP) is the most important, treatable risk factor. Currently, the management of glaucoma is centred at reducing the IOP, and drugs in the form of topical drops are the first line of management. Drugs reduce IOP either by suppressing aqueous humour secretion or improving the aqueous humour outflow. Newer drugs added during the past three decades to the armamentarium of glaucoma treatment have targeted the aqueous outflow. With an evolving understanding of the pathogenesis of glaucoma, the role of 24-hour IOP control and other IOP-independent risk factors affecting ocular blood flow and RGC toxicity is also recognised. The role of available drugs in controlling IOP over 24-hours is being evaluated. Improvement of ocular blood flow and neuroprotection are seen as potential drug targets in preventing the loss of RGC. In this article, we review the pharmacotherapy of glaucoma based on current therapeutic principles.

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Emerging drugs for the treatment of glaucoma: a review of phase II & III trials

Kaplan

Sit

2022

Expert Opinion on Emerging Drugs

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The Effects of Topical Timolol and Latanoprost on Calculated Ocular Perfusion Pressure in Nonglaucomatous Volunteers

Cited by 4 publications

References 55 publications

An Evaluation of Efficacy of Commonly Used First Line Drugs in Terms of Intra Ocular Pressure, Ocular Perfusion Pressure, and Field of Vision in Patients of Primary Open Angle Glaucoma of North Karnataka

An Evaluation of Efficacy of Commonly Used First Line Drugs in Terms of Intra Ocular Pressure, Ocular Perfusion Pressure, and Field of Vision in Patients of Primary Open Angle Glaucoma of North Karnataka

An Update on Pharmacotherapy of Glaucoma

Emerging drugs for the treatment of glaucoma: a review of phase II & III trials

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