The Effects of Trabecular-Bone Loading Variables on the Surface Signaling Potential for Bone Remodeling and Adaptation

Ruimerman, R Ronald; Rietbergen, Bert van; Hilbers, P.A.J.; Huiskes, R.

doi:10.1007/s10439-005-8964-9

Cited by 76 publications

(57 citation statements)

References 36 publications

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“…Several other candidates for the mechanical signal have been proposed, such as fluid flow shear stress (Burger and Klein-Nulend 1999;Burra and Jiang 2009;Rath et al 2010) or micro-damage (Mori and Burr 1993;Robling et al 2006). However, earlier studies have demonstrated that the choice of the mechanical signal is not very critical since most of these signals are highly correlated (Ruimerman et al 2005). Another limitation is that the unit load cases have to be preselected according to the loading conditions in the physiological situation of the bone.…”

Section: Discussionmentioning

confidence: 99%

Bone morphology allows estimation of loading history in a murine model of bone adaptation

Christen

Rietbergen

Lambers

et al. 2011

Biomech Model Mechanobiol

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Bone adapts its morphology (density/microarchitecture) in response to the local loading conditions in such a way that a uniform tissue loading is achieved ('Wolff's law'). This paradigm has been used as a basis for bone remodeling simulations to predict the formation and adaptation of trabecular bone. However, in order to predict bone architectural changes in patients, the physiological external loading conditions, to which the bone was adapted, need to be determined. In the present study, we developed a novel bone loading estimation method to predict such external loading conditions by calculating the loading history that produces the most uniform bone tissue loading. We applied this method to murine caudal vertebrae of two groups that were in vivo loaded by either 0 or 8 N, respectively. Plausible load cases were sequentially applied to micro-finite element models of the mice vertebrae, and scaling factors were calculated for each load case to derive the most uniform tissue strainenergy density when all scaled load cases are applied simultaneously. The bone loading estimation method was able to predict the difference in loading history of the two groups and the correct load magnitude for the loaded group. This result suggests that the bone loading history can be estimated from its morphology and that such a method could be useful for predicting the loading history for bone remodeling studies or at sites where measurements are difficult, as in bone in vivo or fossil bones.

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Section: Discussionmentioning

confidence: 99%

Bone morphology allows estimation of loading history in a murine model of bone adaptation

Christen

Rietbergen

Lambers

et al. 2011

Biomech Model Mechanobiol

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“…This model incorporates the individual actions of the different bone cell types (osteoclasts, osteoblasts, and osteocytes). The osteocytes are assumed to react to the local loading conditions by promoting osteoblastic bone formation, and the model thus incorporates osteocyte mechanosensitivity and mechanotransduction (Huiskes et al 2000;Ruimerman et al 2001Ruimerman et al , 2005.…”

Section: Introductionmentioning

confidence: 99%

Analysis of bone architecture sensitivity for changes in mechanical loading, cellular activity, mechanotransduction, and tissue properties

Cox

Rietbergen

Donkelaar

et al. 2010

Biomech Model Mechanobiol

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Bone has an architecture which is optimized for its mechanical environment. In various conditions, this architecture is altered, and the underlying cause for this change is not always known. In the present paper, we investigated the sensitivity of the bone microarchitecture for four factors: changes in bone cellular activity, changes in mechanical loading, changes in mechanotransduction, and changes in mechanical tissue properties. The goal was to evaluate whether these factors can be the cause of typical bone structural changes seen in various pathologies. For this purpose, we used an established computational model for the simulation of bone adaptation. We performed two sensitivity analyses to evaluate the effect of the four factors on the trabecular structure, in both developing and adult bone. According to our simulations, alterations in mechanical load, bone cellular activities, mechanotransduction, and mechanical tissue properties may all result in bone structural changes similar to those observed in various pathologies. For example, our simulations confirmed that decreases in loading and increases in osteoclast number and activity may lead to osteoporotic changes. In addition, they showed that both increased loading and decreased bone matrix stiffness may lead to bone structural changes similar to those seen in osteoarthritis. Finally, we found that the model may help in gaining a better understanding of the contribution of individual

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“…The mechanisms by which osteocytes translate mechanical stimuli into bone formation have been found to be best explained in terms of SED 21 and this relationship has been well documented in animal studies. 22 A more recent study 23 has shown that mechanical strain can in fact promote bone ingrowth and enhance the biological fixation of cementless implants.…”

Section: Discussionmentioning

confidence: 96%

An experimental glenoid rim strain analysis for an improved reverse anatomy shoulder implant fixation

Mordecai

Lambert

Meswania

et al. 2011

Journal Orthopaedic Research

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Loosening of glenoid components in TSA is a main cause of failure. In reverse anatomy TSA designs used for unstable joints, fixation is particularly demanding. Strains developed around the glenoid rim of biomechanical sawbone scapulae implanted with (a) the original fixed-fulcrum Bayley-Walker glenoid prosthesis in current clinical use, and (b) a revised version with conical crosssection, were compared. The conical shape of the revised design was hypothesized to produce greater strains in the glenoid rim than the original tapered screw design. The 2D strain field at three accessible locations around the rim of each scapula was measured with three-element rosette strain gauges for two types of simulated cancellous bone fill under applied physiologically relevant loads. The average strain energy densities around the rim for the conical design were greater than for the original design by a factor of 1.55-2.25 for all loading conditions. Results indicate that a significantly greater proportion of load was directed toward cortical bone in the conical design, thus promoting cortical bone loading.

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The Effects of Trabecular-Bone Loading Variables on the Surface Signaling Potential for Bone Remodeling and Adaptation

Cited by 76 publications

References 36 publications

Bone morphology allows estimation of loading history in a murine model of bone adaptation

Bone morphology allows estimation of loading history in a murine model of bone adaptation

Analysis of bone architecture sensitivity for changes in mechanical loading, cellular activity, mechanotransduction, and tissue properties

An experimental glenoid rim strain analysis for an improved reverse anatomy shoulder implant fixation

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