The effects of tramadol on hepatic ischemia/reperfusion injury in rats

Mahmoud, Mona F.; Gamal, Samar; Shaheen, Mohamed A.; El-Fayoumi, Hassan M.

doi:10.4103/0253-7613.182882

Cited by 7 publications

(8 citation statements)

References 22 publications

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“…Thereby, some evidences suggest that peripheral actions of tramadol involve increasing in antioxidant defenses. Mahmoud et al 20 , showed the use of this substance reduced oxidative by means of glutathione peroxidase overexpression and decreasing in MDA formation. On the same way, Takhtfooladi et al 21 observed increasing in catalase and superoxide dismutase in skeletal muscle.…”

Section: ■ Discussionmentioning

confidence: 99%

Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats

et al. 2017

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Section: ■ Discussionmentioning

confidence: 99%

Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats

et al. 2017

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“…Serum and tissue MDA levels in ischemia-reperfusion rats were significantly increased. The muscle tissue GSH, SOD, and CAT levels in the Ischemia-reperfusion group were significantly lower than the control group [52].…”

Section: The Antioxidant Effects Of Tramadol On Ischemia-reperfusion ...mentioning

confidence: 70%

“…It also increased IL-10 levels in hepatic tissues. TR reduced oxidative stress parameters except for SOD activity [52].…”

Section: The Antioxidant Effects Of Tramadol On Ischemia-reperfusion ...mentioning

confidence: 93%

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Tramadol-Induced Organ Toxicity via Oxidative Stress : A Review Study

Mohammadnejad

Soltaninejad

2022

IJMTFM

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Background: Tramadol (TR) is a synthetic opioid-like centrally acting analgesic used for moderate to severe pain management in various diseases. Numerous investigations have supported the association between tramadol use and increased levels of oxygen-free radicals. Mass production of reactive oxygen species produces secondary toxic compounds. This could damage the internal components of the cell and ultimately causes organ damage. There exists a growing trend of tramadol abuse and the increasing reports of poisoning, abuse, and mortality due to this drug. Thus, the present study aimed to review the animals and human studies on the effects of acute and chronic exposure of tramadol in inducing organ toxicities through oxidative stress. Methods: Pubmed, Google Scholar, and Scopus bibliographic databases were searched for studies that investigated oxidative stress as a mechanism of toxicity by tramadol. A manual search of reference lists of the retrieved articles was conducted. Data were collected from 2000 to 2021 (up to June 2021). Results: From 28 articles concerning experimental and human studies of TR-induced oxidative stress organ damage, which included in this review, the occurrence of lipid peroxidation, alteration in the levels of total antioxidant capacity, and other oxidative stress biomarkers in many organs such as the brain, liver, kidney, adrenal and lung in the experimental studies of tramadol exposure have been observed. Conclusion: Oxidative stress could be considered the most critical toxic mechanism in TR-induced tissue damage.

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“…It inhibits reuptake of noradrenaline and serotonin (5HT) 13 . Tramadol is a synthetic drug with cardio-protective and hepatoprotective effect 14 . Metabolism of tramadol occurs in the liver 15 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of Tramadol Versus Tramadol and Paracetamol in Postop Pain Management after C-Section

Salamat¹,

Khan²,

Ali³

et al. 2021

PJMHS

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Background: Multimodal technique of pain control is better than unimodal technique in perioperative time. Both tramadol and paracetamol are commonly used for pain control. Aim: To compare the tramadol alone versus tramadol with paracetamol in pain management after C- section. Method: 150 patients with ASA class P1&P2 undergoing elective cesarean section under general anesthesia were included in this study and were divided into group A & B by random number table. In both group tramadol 1mg/kg body weight intravenous was given after delivery of baby and in group B intravenous paracetamol 15 mg/kg body weight was given additionally and same doses were given in postop after 8 hours for 24 hs of post-surgery. Result: Mean age in group A was 31.04±5.35 years and in group B it was 29.64±5.92. Mean pain score in group A was 1.19±0.81 and in group B it was 0.60±0.75. The degree of pain was low in group B and patients were more comfortable as compared to group A patients. Conclusion: Tramadol plus paracetamol has better pain control as compared to tramadol alone. Keywords: Tramadol, Paracetamol, Cesarean Section, VAS.

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The effects of tramadol on hepatic ischemia/reperfusion injury in rats

Cited by 7 publications

References 22 publications

Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats

Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats

Tramadol-Induced Organ Toxicity via Oxidative Stress : A Review Study

Comparison of Tramadol Versus Tramadol and Paracetamol in Postop Pain Management after C-Section

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